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Popular Abstract in Swedish Den främsta orsaken till att cancer kan leda till döden är att tumörceller växer in i angränsande vävnad (invasiv) och tar sig in i blodet eller lymfsystemet och på så sätt sprids (metastaserar) till andra ställen i kroppen och stör funktionen i livsviktiga organ dvs tumören får ett aggressivt växtsätt. Det är därför viktigt, både ur prognostisk och terapeutisk synvinkeThe progressive process of tumour invasion and generation of metastases is the primary cause of death for most patients with cancer. Some of the regulatory components of this progressive process are adhesion, migration, and proteolysis. Urokinase -type plasminogen activator (u-PA) is a serine protease associated with tissue remodelling, cellular invasiveness, matrix degradation, angiogenesis, and

Popular Abstract in Swedish Den molekylära processen under vilken DNA-information förs över till RNA-information kallas transkription. Transkription styrs främst i samverkan med många speciella molekyler som kallas transkriptionsfaktorer. Zinkfinger proteiner är en av de vanligast förekommande klasserna av reglerande proteiner i eukaryota celler där de inverkar på en mängd av cellulära aktiviteterThe molecular process under which message in DNA is relayed onto RNA is called transcription, and it accomplished through involvement of so-called transcription factors. Zinc finger proteins are one of the most abundant classes of regulatory proteins in eukaryotic cells where they play central roles in a variety of cellular activities. A classical zinc finger is a small protein motif with a simple

The purpose of this study was to describe, and analyse the effect of an intervention on, the biomechanical workload in the neck and shoulder region of female hairdressers. Arm elevation was measured by inclinometers and muscular load of m. trapezius by electromyography. The intervention comprised working technique recommendations, e.g. to work with less elevated arms and more relaxed muscles. The

Popular Abstract in Swedish Svavel är den mest förekommande föroreningen i råolja och finns närvarande i form av organiska tioler, sulfider, disulfider och tiofener. Vid förbränning av dessa bildas svaveloxider som kombinerat med vatten i atmosfären bidrar till surt regn. Dessutom har dessa föreningar en tendens att kontaminera ädelmetall-baserade katalysatorer som används för hydrokrackning i rafThe coordination and fundamental transformations of organosulfur compounds to polynuclear metal complexes has been studied as models for possible surface species in industrial HDS processes. Reactions between [Os3(CO)11(NCMe)] and various thiols have been studied by UV-Vis, IR and NMR spectroscopy and all experimental findings indicate that the reactions proceed via a two-step consecutive process

The role of accountants in organizations is intriguing in the current context of the broad changes in the profession observed by many. Mainly because of technological advancements, what has previously required a considerable amount of time and effort, i.e. bookkeeping & reporting, has been assumed to ‘just happen’ easily, with a corollary that it should not be taken for granted, that the accou

The comminution processes are complex and there has thus far been no, previously published, efficient way to calculate the cost per product and metric ton. The proposed model has been adapted to fit the currently investigated process of crushing and screening (C&S). Deriving from the original model, the proposed new model is presenting the result in cost per metric ton of raw material. It has

An experiment with small roundabouts – as speed reducing measures - was carried out in a Swedish city. The purpose of the study was to test the large scale and long term effects of the roundabouts. The results showed that the roundabouts reduced the speed considerably at the junctions and on links between roundabouts. The lateral displacement the roundabout forces the driver to has a great importa

Artiklarna i denna antologi belyser hur nutida forskningsrön och vetenskaplig diskussion om frågor som kaos och komplexitet, förutsägbarhet och kausalitet, emergens och ordning påverkar traditionella religiösa och vetenskapliga tankar om oförutsägbarhet, slump, ändamål och skapelse. Teologer och naturvetare från sekulär, protestantisk, katolsk och ortodox tradition visar hur ordning och oordning h

The t(1;19)(q23; p13), one of the most common translocations in childhoodand adult acute lymphoblastic leukaemias (ALLs), usually results in fusion of exons 1-16 of TCF3 (previously E2A) and exons 3-9 of PBX1. However, some t(1;19)-positive ALLs are negative for this chimaera. We here report an alternative TCF3/PBX1 transcript, fusing exon 17 of TCF3 with exon 5 of PBX1, in a paediatric t(1;19)-po

Activated protein C inhibits the procoagulant function of activated factor V (FVa) through proteolytic cleavages at Arg-306, Arg-506, and Arg-679. The cleavage at Arg-506 is kinetically favored but protected by factor Xa (FXa). Protein S has been suggested to annihilate the inhibitory effect of FXa, a proposal that has been challenged. To elucidate the effects of FXa and protein S on the individua

Calcium- and integrin-binding protein 1 (CIB1) is a ubiquitous, multifunctional regulatory protein consisting of four helix-loop-helix EF-hand motifs. Neither EF-I nor EF-II binds divalent metal ions; however, EF-III is a mixed Mg2+/Ca2+-binding site, and EF-IV is a higher-affinity Ca2+-specific site. Through the generation of several CIB1 mutant proteins, we have investigated the importance of th

We studied the projection patterns of antennal lobe (AL) interneurones sensitive to plant volatiles and female-produced sex pheromone components in the female moth, Spodoptera littoralis. Ten compounds (eight plant-derived compounds and two sex pheromone components) were singly applied to the antenna and, using intracellular recording and staining techniques, the physiological and morphological ch

OBJECTIVES: To investigate the clinical value of human glandular kallikrein 2 (hK2) compared with free (f) and total (t) prostate-specific antigen (PSA) in the early detection of prostate cancer (PCa). METHODS: In PCa screening conducted in 1995 to 1996 in Goteborg, Sweden, 5853 of 9811 randomly selected men (aged 50 to 66 years; median 61) accepted PSA testing; those with tPSA levels of 3. 0 ng/m