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The number of patients with Alzheimer's disease (AD) is likely to triple in a few decades as the world's population ages. Given the high personal and societal burden of this disease, it is imperative to identify its risk factors. The etiology of AD is still not fully understood, but environmental factors have emerged as plausible important risk factors on the population-level. In this short review
The article ‘Whither Plastics?—Petrochemicals, plastics and sustainability in a garbage-riddled world’ discusses a number of recent issues around plastics, including plastics’ dependence on fossil fuels, its contribution to ocean waste, and its possible impact on human health [M. Jefferson, “Whither plastics?—Petrochemicals, plastics and sustainability in a garbage-riddled world,” Energy Res. Soc.
Cholinergic neurons of the basal nucleus complex (BNC) respond to nerve growth factor (NCF), the first member of a polypeptide gene family that also includes brain‐derived neurotrophic factor (BDNF), neurotrophin‐3 (NT‐3), and neurotrophin‐4/5 (NT‐4/5), NGF, BDNF, and NT‐3 are enriched in hippocampus. In addition, NGF and, more recently, BDNF have been shown to stimulate the cholinergic differenti
East African landscapes today are the result of the cumulative effects of climate and land-use change over millennial timescales. In this review, we compile archaeological and palaeoenvironmental data from East Africa to document land-cover change, and environmental, subsistence and land-use transitions, over the past 6000 years. Throughout East Africa there have been a series of relatively rapid
Based on the experiences of insufficient burnout in industrial fluidized bed furnaces despite adequate mixing and availability of oxidizer, the influence of potassium on CO and H2 oxidation in combustion environments was investigated. The combustion environments were provided by a laminar flame burner in a range relevant to industrial furnaces, i.e. 845 °C to 1275 °C and excess air ratios ranging
BACKGROUND: Breastfeeding in public continues to be contentious with qualitative evidence confirming that women face many challenges. It is therefore important to gain understanding of not only the challenges but also what women perceive is helpful to breastfeed in public.METHODS: A cross-sectional study was conducted with women living in Australia, Ireland or Sweden currently breastfeeding or hav
Aims: Although nitrogen (N) fixation by moss-associated bacteria is the main source of new N in N-limited ecosystems like arctic tundra, we do not know which nutrient, molybdenum (Mo) or phosphorus (P), is rate-limiting for sustaining this process in the long-term. Further, how moss-associated N2 fixation impacts the belowground microbial regulation of decomposition remains unresolved. Methods: Mo
In older patients with Parkinson’s disease (PD), the use of dopamine agonists (DA) has been limited due to uncertainties related to their tolerability in spite of potential gains with the advent of longer acting or transdermal therapies. Comparative real-life data addressing the tolerability of DA therapy across age ranges are currently sparse. This study addressed the tolerability (Shulman criter
Previous studies reported conflicting results regarding association of insulin receptor substrate 1 (IRS1) gene variation with type 2 diabetes (T2D) and insulin resistance (IR) in different ethnic groups. We examined the association of rs7578326, rs2943641, and rs4675095 in the IRS1 gene with T2D and related traits in a population from Bosn
Abstract Body:Starting out from a joint Nordic collaboration initiative in 2008 resulting in the development of a Nordic Master Program in Gerontology (NordMaG), followed by the establishment of graduate schools integrated with two national excellence centers for aging research in Sweden, in 2014 the Swedish National Graduate School for Competitive Science on Aging and Health (SWEAH) was establish
It is hypothesized that insulin resistance and related metabolic factors may influence breast cancer risk, however the epidemiological evidence remains inconclusive. We conducted a case-control study nested in a prospective cohort in Northern Sweden, to clarify the associations of body mass index (BMI), leptin, adiponectin, C-peptide, and glycated haemoglobin (HbA1c) with breast cancer risk. We al
Popular Abstract in Swedish Ultraljudundersökning av hjärtat (ekokardiografi) har under det senaste decenniet fått en alltmer framträdande roll i diagnostiken av hjärtsjukdomar och används ofta för att vägleda medicinska beslut inom hjärtsjukvården. Ekokardiografi är av central betydelse framförallt vid undersökning av vänsterkammarens pumpförmåga (systoliska funktion) och hjärtklaffarnas funktionTwo specific areas of development in echocardiography are assessment of left ventricular (LV) diastolic function and myocardial ischemia. This thesis describes echocardiographic methodology in these two areas. In the first study, two new echocardiographic methods, the early diastolic flow propagation velocity (Vp) and the early diastolic atrioventricular plane downward slope (EDS), were tested as
