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Bone and soft tissue tumors (BSTT) belong to a diverse group of solid tumors of mesenchymal origin, with a large number of histological types affecting individuals of all ages. The general aim of the present thesis (Articles I-V) was to investigate in detail the genetic aberrations in selected subtypes of benign and malignant BSTT. Aberrations identified by chromosome banding analysis were studied
Popular Abstract in Swedish Jag har huvudsakligen studerat läderbaggen Osmoderma eremita, en ca tre cm lång skalbagge som lever inne ihåliga träd. Larverna av denna s k bladhorning lever av den döda veden på stammens insida i levande ihåliga lövträd (i Sverige främst ek) och av mulmen inne i trädet (den mjölliknande blandning av nedbruten ved, vedsvampar, löv, gamla fågelbon, fladdermöss, insekterThis thesis starts with a review of different biodiversity assessment methods in forests and the rest deals with the metapopulation ecology of Osmoderma eremita, a threatened beetle living in hollow trees. I concentrate on the effect of dispersal, habitat quality and habitat history for the presence, population size and future survival of this species. Dispersal was studied by using both capture-m
In this paper it is shown how a convolutional code can be used either to detect errors or to correct erasures. The erasure correction is related to the error detection. Using the active burst distance lower bounds on the error and erasure correction as well as error detection are obtained for convolutional codes.
Antibodies are important proteins participating in a number of reactions to protect us from harmful diseases. Apart from this important function, they are also useful in different technical and medical applications. This, however, relies on our possibility to produce antibodies in vitro. In the first part of my thesis a new technology called CDR shuffling was developed to create diverse and highly
The paper discusses the motivation for and outcome of the addition of socially oriented so called “off-task” conversational abilities to an existing “teachable agent” (TA) in an educational mathematics game. The purpose of the extension is to affect constructs known to promote learning, such as self-efficacy and engagement, as well as enhancing students’ experiences of the game. A comparison of st
We present the first implementation of Thread-Level Speculation in combination with Just-in-time compilation. The implementation is done in Google’s V8, a well-known JavaScript engine, and evaluated on 15 popular web application executing on 2, 4, and 8 core computers. Our results show an average speedup of 2.9 on 4 cores, without any JavaScript code modifications. Further, we have found that the
Popular Abstract in French Phytoplancton invasif : génétique des populations, phylogéographie, et facteurs facilitant l’invasion par Gonyostomum semen De nos jours, les espèces invasives représentent une importante menace à la biodiversité. Une espèce invasive colonise un nouvel environnement, ou elle était absente, et atteint de forte densité rapidement, diminuant l’abondance ou remplaçant les esnvasive species is a major threat to ecosystems and biodiversity. Invasions by macroorganisms have been intensively studied, but little is known concerning microbial invasions. In aquatic environments, phytoplankton, i.e. autotrophic microbes, have a key role as primary producers. In my thesis, I focused on the population genetic structure and phylogeography of the freshwater raphidophyte Gonyosto
Popular Abstract in Swedish Under 1980-talet blev riskerna med blodtransfusioner alltmer uppenbara. Störst uppmärksamhet väckte ett antal fall med spridning av HIV- (AIDS) smitta, men ännu vanligare var spridning av ett virus som kunde orsaka leverinflammation. Dessa risker är numera nästan helt försvunna men dels kvarstår en oro för spridning av nya, okända virus, dels har det visat sig att blodtBlood loss in major arthroplasty may be abundant and often necessitates blood transfusions. These may transmit disease and entail an immunological burden to the recipient. After trauma and surgery, the fibrinolytic system reacts with a short period of increased activity, followed by a fibrinolytic shut-down. In this thesis we investigated the impact of the early fibrinolytic activation on blood
The Homogeneous Charge Compression Ignition (HCCI) principle holds promise to increase efficiency and to reduce emissions from internal combustion engines. As HCCI combustion lacks direct ignition timing control and auto-ignition depends on the operating condition, control of auto-ignition is necessary. Since auto-ignition of a homogeneous mixture is very sensitive to operating conditions, a fast
In about four decades, ion beam analysis (IBA) techniques have evolved to become well established analytical techniques for routine analysis in archaeological, bio-medical, geological and environmental sciences. They basically make use of the different interactions of a high energy ion beam (of few MeV/amu) with the specimen matter so they pressupose the use of a particle accelerator. In laborator
Abstract is not available
The present study was designed to describe the pattern of long-term formal support received by people with mental disorders, and to investigate the relationship between the medical, psychological and social characteristics of the participants and types of formal support. This study is based on a cohort (n = 192) of people born in 1902 and 1903 in a community in Southern Sweden. The research partic
Free neutral potassium clusters of two different mean sizes were produced using a gas aggregation source. The K 3p core level was probed by means of synchrotron radiation based photoelectron spectroscopy. The absolute binding energy and the intensity ratio of the surface and bulk spectral features were used to obtain independent estimates of the cluster size. Plasmon satellites in core level spect
