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Intracellular Ca2+ transients, monitored by the calcium-sensitive dye, fluo-3, were studied during isometric twitches and tetani in intact single muscle fibres of the frog (sarcomere length, 2.2 mm; temperature, 2-5 or 10-12 ºC). The Ca2+ transient during twitch stimulation was very brief when compared with the isometric force. In a population of fibres studied, a greater amplitude of the Ca2+ tr
The PHENIX experiment at the Relativistic Heavy Ion Collider has performed a systematic study of K-S(0) and K*(0) meson production at midrapidity in p + p, d + Au, and Cu + Cu collisions at root s(NN) = 200 GeV. The K-S(0) and K*(0) mesons are reconstructed via their K-S(0) -> pi(0)(-> gamma gamma) pi(0)(-> gamma gamma) and K*(0) -> K-+/-pi(-/+) decay modes, respectively. The measured transverse-m
OBJECTIVE - To compare the sensitivity and specificity of luciferase immunoprecipitation (LIPS) with radioimmunoprecipitation (RIP) for the measurement of autoantibodies to the type 1 diabetes autoantigens glutamic acid decarboxylase 65 (GAD65) and insulinoma-associated protein (IA)-2 beta. RESEARCH DESIGN AND METHODS - Sera from 49 type 1 diabetic patients and 100 nondiabetic control subjects fro
Although temperature is a key parameter controlling the activity and growth of all microorganisms, information about how water temperature may structure the bacterioplankton community is not consistent. We examined the relationship between temperature and the community composition, cell volume, and morphology of marine bacterioplankton in 4 continuous cultures harbouring multispecies communities.
Background: In animal studies, perfluorinated alkyl substances affect growth and neuro-behavioural outcomes. Human epidemiological studies are sparse. The aim was to investigate the association between pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and offspring behaviour and motor development at 5-9 years of age. Methods: Maternal sera from the IN
The aim of this study is to provide a survey of systematic reviews that have evaluated the effects of psychosocial interventions for adult people with intellectual disabilities and/or an autistic syndrome with concurrent mental health problems. Reviews for inclusion were identified through searches of 10 electronic databases. The authors found that 3 out of 126 published reviews met the inclusion
Research indicates a crisis in the journalistic field due to economic, technological, institutional and cultural shifts. This seems to have led to a paradigm shift in arts journalism, from a cultural to a journalistic focus, and a loss of autonomy for culture departments in the Swedish press. This article investigates how arts journalists’ professional values are affected by this presumed autonomy
Ankylosing spondylitis (AS) is a chronic inflammatory disease in which genetic factors play a central role. The efficacy of TNF blockers has reoriented research in this field in order to explain the influence of TNF in AS pathogenesis. The objective of this study was to access the influence of single nucleotide polymorphisms (SNPs) at positions -308 and -238 of the promoter region of TNF gene on A
Based on an interview with a hip-hop artist from Eastern Poland, this article critically assesses amateur art pro-duction proliferating throughout the globe today through individuals’ creative usages of new ICTs and new media affordances. The post-Fordist material and ideological context of contemporary social life is the main focus point of the article’s critique. Scarcity, dispossession, and ent
Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with poor prognosis in urothelial bladder cancer in several independent studies. The present study provides a first description of clinicopathological characteristics of incident urothelial cancers, not only located to the bladder, in the prospective, population-based cohort stu
MAX IV will be Sweden's next-generation high-performance synchrotron radiation source. The project has recently been granted funding and construction is scheduled to begin in 2010. User operation for a broad and international user community should commence in 2015. The facility is comprised of two storage rings optimized for different wavelength ranges, a linac-based short-pulse facility and a fre
The dopamine (DA) precursor l-DOPA has been the most effective treatment for Parkinson's disease (PD) for over 40 years. However, the response to this treatment changes with disease progression, and most patients develop dyskinesias (abnormal involuntary movements) and motor fluctuations within a few years of l-DOPA therapy. There is wide consensus that these motor complications depend on both pre
Multi-proxy analysis was performed on a radiocarbon-dated core, collected from a relic oxbow lake in the Limpopo River-plain, Mozambique, with the aim to reconstruct paleo-environment and past flooding of the lower river system over the past c. 800 years. An additional objective was to evaluate and investigate the potential use of different proxies as recorders of paleo-flooding events and paleo-e
Popular Abstract in Swedish Osteoporos, eller benskörhet, är en sjukdom som orsakas av störning i skelettets ämnesomsättning. Denna rubbning ger upphov till förändringar i benets uppbyggnad men minskar även mängden benmassa. Osteoporos ger i sig själv inte upphov till besvär men medför en ökad risk för att drabbas av benbrott (frakturer). Dessa frakturer kan vid uttalad benskörhet uppkomma redan vThe number of vertebral fractures has increased during the last few decades.The increase could at least partly be explained by the increasing proportion of elderly in society since these fractures are more commonly found in elderly than in young individuals. Low bone mass and osteoporosis which are also partly related to aging are risk factors for fracture but both age and low bone mass are indepe
BACKGROUND: Phthalates may pose a risk for perinatal developmental effects. An important question relates to the choice of suitable biological matrices for assessing exposure during this period. OBJECTIVES: This study was designed to measure the concentrations of phthalate diesters or their metabolites in breast milk, blood or serum, and urine and to evaluate their suitability for assessing perina
To investigate whether children with Attention Deficit/Hyperactivity Disorder have lower levels of Vitamin D3 at birth than matched controls.
Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that JNK1 regulates the dendritic field of L2/3 and L5 pyramidal neurons of the mouse
This paper presents an existence theory for small-amplitude Stokes and solitary-wave solutions to the classical water-wave problem in the absence of surface tension and with an arbitrary distribution of vorticity. The hydrodynamic problem is formulated as an infinite-dimensional Hamiltonian system in which the horizontal spatial coordinate is the time-like variable. A centre-manifold technique is
MARS is the system established and maintained by the European Commission in order to collect information related to major industrial accidents in EU Member States in the context of the Seveso II Directive. One of the main purposes of the MARS database is to provide information for learning from the accidents to avoid similar events. Probably, the most important issue for the learning is the determ
