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There is a growing interest for the possibility of using peripheral blood cells (including platelets) as markers for mitochondrial function in less accessible tissues. Only a few studies have examined the correlation between respiration in blood and muscle tissue, with small sample sizes and conflicting results. This study investigated the correlation of mitochondrial respiration within and across
The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this process might also cause or contribute to inflammatory disease and lung failure following SARS-CoV-2 infection. To test this hypothesis, we developed a nove
Objective: Acceptance and commitment therapy (ACT) is a transdiagnostic, behavioral treatment focusing on common processes behind different diagnoses. Internet-based treatment programs can improve access to treatment and easily be integrated into the individual’s life. Method: This single-arm, pre-post-follow-up pilot study examined the acceptability, safety, and effectiveness of internet-based AC
Participants judged the risk of an infection during a face to face conversation at different interpersonal distances from a SARS-CoV-2 infected person who wore a face mask or not, and in the same questionnaire answered questions about Corona related issues. Keeping a distance to an infected person serves as a protective measure against an infection. When an infected person moves closer, risk of in
Ketamine is a common anesthetic used in human and veterinary medicine. This drug has recently received increased medical and scientific attention due to its indications for neurological diseases. Despite being applied for decades, ketamine’s entire metabolism and pharmacological profile have not been elucidated yet. Therefore, insights into the metabolism and brain distribution are important towar
Corrosion of embedded steel reinforcement is the prime influencing factor that deteriorates the structural performance and reduces the serviceability of reinforced concrete (RC) structures, especially during earthquakes. In structural elements, RC columns play a vital role in transferring the superstructure's load to the substructure. The deterioration of RC columns can affect the structures' over
Nudging, i.e. the framing of decision environments to exploit known behavioral biases in order to induce certain outcomes, has received considerable attention as a potential policy tool in recent years. Motivated as preserving freedom of choice while making people better off according to their own judgment, nudging seemingly comes at fairly little responsibility for the nudger, i.e. policy makers,
This paper deals with the prediction of train-induced building vibrations by using a numerical framework. The framework is based on a sub-structure approach, where a sequence of different models are used. The free-field ground vibrations and the track receptance are calculated using 2.5D technique where the railway track is represented by finite elements that couple to a dynamic stiffness of the u
Massively parallel sequencing (MPS) is increasingly applied in forensic short tandem repeat (STR) analysis. The presence of stutter artefacts and other PCR or sequencing errors in the MPS-STR data partly limits the detection of low DNA amounts, e.g., in complex mixtures. Unique molecular identifiers (UMIs) have been applied in several scientific fields to reduce noise in sequencing. UMIs consist o
Summary: Antiresorptive medications do not negatively affect fracture healing in humans. Teriparatide may decrease time to fracture healing. Romosozumab has not shown a beneficial effect on human fracture healing. Background: Fracture healing is a complex process. Uncertainty exists over the influence of osteoporosis and the medications used to treat it on fracture healing. Methods: Narrative revi
The presence of amyloid fibrils is a hallmark of several neurodegenerative diseases. Some amyloidogenic proteins, such as α-synuclein and amyloid β, interact with lipids, and this interaction can strongly favour the formation of amyloid fibrils. In particular the primary nucleation step, i.e. the de novo formation of amyloid fibrils, has been shown to be accelerated by lipids. However, the exact m
Revealing the local structure information of relaxor ferroelectrics is necessary for a clear understanding of their structure-property relationships, especially the determination of the size of polar nanoregions (PNRs), which is still a long-standing challenge. In this work, the local structure of the pseudo-cubic solid solutions 0.60Bi(Mg1/2Ti1/2)O3-0.40PbTiO3 and 0.65Bi(Mg1/2Ti1/2)O3-0.35PbTiO3,
The effects of climate change have led to increasing concern regarding global emissions, especially carbon dioxide (CO2) emissions. A significantcontributor to these emissions is the combustion of fossil fuels in internal combustion engines (ICEs). This combustion process is also responsible forother harmful emissions such as carbon monoxide (CO), soot, and nitrogen oxides (NOx). Although signific
Representations of the slim body have traditionally been at the centre of scholarly interest in dieting culture, whereas food often remains a shadowy presence compared with more persistent themes of body discipline, slenderness and anti-fat messages. This article offers a different perspective on weight-loss dieting, placing food at the very centre of the analysis. By examining different diets in
The Storage Location Assignment Problem (SLAP) is of central importance in warehouse operations. An important research challenge lies in generalizing the SLAP such that it is not tied to certain order-picking methodologies, constraints, or warehouse layouts. We propose the OBP-based SLAP, where the quality of a location assignment is obtained by optimizing an Order Batching Problem (OBP). For the
Accumulating evidence demonstrating higher cerebrospinal fluid (CSF) α-synuclein (αSyn) levels and αSyn pathology in the brains of Alzheimer's disease (AD) patients suggests that αSyn is involved in the pathophysiology of AD. To investigate whether αSyn could be related to specific aspects of the pathophysiology present in both sporadic and familial disease, we quantified CSF levels of αSyn and as
With continuously improving signal-to-noise ratios, a statistically sound analysis of quasi-elastic neutron scattering (QENS) spectra requires to fit increasingly complex models which poses several challenges. Simultaneous fits of the spectra for all recorded values of the momentum transfer become a standard approach. Spectrometers at spallation sources can have a complicated non-Gaussian resoluti
This paper examines the local exponential stability (LES) of trajectories for nonlinear systems on Riemannian manifolds. We present necessary and sufficient conditions for LES of a trajectory on a Riemannian manifold by analyzing the complete lift of the system along the given trajectory. These conditions are coordinate-free which reveal fundamental relationships between exponential stability and
Sustainable migration is the new objective of the EU migration policy. But what does this mean in terms of legal design? What instruments should be put in place to achieve it? And most importantly what does it imply for migrants’ rights? While sustainability has attracted scholarly attention in law and politics already since the 1990s, sustainable migration is an extremely understudied topic with
