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The purpose of this study was to measure the pharmacokinetics and tissue accumulation of N-acetylamino-3-chloro-N-(2-diethylamino-ethyl) benzamide (NACPA) after oral or intravenous administration at a single dose of 25 mg/kg to female W/Fu rats. The serum pharmacokinetics of NACPA were characterized by rapid absorption, distribution and elimination. However, in comparison with its parent compound,
A semistructured personal interview was performed with 29 carriers of hemophilia A or B, 1-5 years after a pregnancy in which prenatal diagnosis (PND) was performed by fetal blood sampling. Fetal blood sampling by fetoscopy was significantly more often reported by the women to the more trying than expected than was ultrasound-guided heart puncture. Of 29 women 13 was classified as having experienc
Nitric oxide (NO) acts as a modulator of neuronal transmission in mature neuronal systems, including the retina. Recently, NO has also been suggested to have a trophic function during development. We examined immunocytochemically the distribution of NO-producing cells in developing and transplanted rabbit retinas. An antibody detecting the neuronal isoform of its biosynthetic enzyme, nitric oxide
In this study we have compared the interaction of human MHC class I molecules with IgG heavy chain (HC) binding protein (BiP), calnexin, calreticulin, tapasin and TAP in beta(2)-microglobulin (beta(2)m)- or TAP-deficient cells, as well as in wild-type B-LCL cells. Distinct differences between the association of HC and these endoplasmic reticulum (ER) proteins were found in the three cell lines. In
In this study steady-state natural convection for Al2O3 and CuO nanofluids inside different enclosures are numerically investigated. Natural convection is concerned due to a temperature difference between hot and cold surfaces. Rectangular and curved enclosures are investigated. The Boussinesq approximation is used to form the governing equations and the commercial software package ANSYS Fluent ve
The evaluation of emergency, disaster and crisis management exercises supports both individual and organisational learning, facilitates the development of response capabilities, and helps to determine whether the current level of preparedness is good enough. Nevertheless, despite its importance in the field of disaster risk management, there is a lack of a comprehensive overview of research in the
When a voter chooses between large and small parties in a coalition, strategic reasons may be the tie-breaker. “Strategic voting” is often defined as a vote for another party than one’s most preferred one with the intention to affect the outcome of the election. The presence of coalitions can sometimes be argued to lead to less strategic voting, whereas others claim that coalitions create more str
In the land pulmonate snailCepaea nemoralis, immunocytochemical localization of methionine- and leucine-enkephalin-like substances was demonstrated in specific populations of brain neurons. Methionine-enkephalin reactivity is also present in the peripheral nervous system as (i) abundant axonal projections of central neurons to the sole of the foot, and (ii) sparse local neurons of the head and man
Immunoreactivity to antisera raised against scrotonin, a biogenic amine, and FMRFamide, a neuropeptide, reveals two different populations of neurons in the nervous system of Hutchinsoniella macracantha. Neural transmission may thus use at least transmitter substances that are found in other crustaceans and invertebrates.
Niveas Rota, new genus, and its two new species, N. agassizi Rota, new species, and N. kone Rota, new species, are described and illustrated. Niveas is assigned to the subfamily Choreutinae based on morphological and molecular data. Niveas agassizi is currently known only from Kenya and only from female specimens. Niveas kone has been found on the Solomon Islands and in Papua New Guinea (PNG). In
3,4-dihydroxyphenylalanine (DOPA), 3,4,5-trihydroxyphenylalanine (5-OH-DOPA), 5-S-cysteinylDOPA (5-SC.D) and 2-S-cysteinylDOPA (2-SC.D) in the tentacles of the sea anemone, Metridium senile, were studied by the combined use of differential centrifugation of tissue homogenates, ultracentrifugation on sucrose density gradients, HPLC and electron microscopy. DOPA, 5-OH-DOPA and o-diphenol:O2 oxidored
The adiabatic film-cooling effectiveness on a thermal barrier coating surface is investigated numerically. A film-cooling hole with an inclination angle of 35° is placed upstream the deposition configuration. The depositions are arranged on the external wall with three different positions. For no-mist models, the cooling performances downstream the wall are investigated for the blowing ratios of 0
OBJECTIVE: To develop a prognostic model to predict disease outcomes in individual patients with Parkinson disease (PD) and perform an external validation study in an independent cohort.METHODS: Model development was done in the Comorbidity and Aging in Rehabilitation Patients: The Influence on Activities (CARPA) cohort (Netherlands). External validation was performed using the Cambridgeshire Park
BACKGROUND: Clinicians normally use subjective rating scales to estimate the impairment of patients with Parkinson's disease (PD). More objective and quantitative methods of assessment would greatly aid our understanding of the disease. One promising approach is to measure reaction time: the large amount of data recorded in a short period provides precise, reproducible evaluation of the underlying
Genetic characterisation (SSU rRNA genotyping) and Scanning Electron Microscope (SEM) imaging of individual tests were used in tandem to determine the modern species richness of the foraminiferal family Elphidiidae (Elphidium, Haynesina and related genera) across the Northeast Atlantic shelf biomes. Specimens were collected at 25 locations from the High Arctic to Iberia, and a total of 1013 indivi
