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To cite this article: Bogefors J, Rydberg C, Uddman R, Fransson M, Månsson A, Benson M, Adner M, Cardell LO. Nod1, Nod2 and Nalp3 receptors, new potential targets in treatment of allergic rhinitis? Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02315.x. Abstract Background: Recently, a new set of pattern-recognition receptors, the nucleotide-binding oligomerization domain (Nod)-like receptors (NLRs),
During asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract for extended periods of time without causing symptoms of urinary tract infection. Previous studies indicate that many Escherichia coli (E. coli) strains that cause ABU have evolved from uropathogenic E. coli (UPEC) by reductive evolution and loss of the ability to express functional virulence factors. For instance, the prot
BACKGROUND: The HMGA2 gene encodes a protein that alters chromatin structure. Deregulation, typically through chromosomal rearrangements, of HMGA2 has an important role in the development of several mesenchymal neoplasms. These rearrangements result in the expression of a truncated protein lacking the acidic C-terminus, a fusion protein consisting of the AT-hook domains encoded by exons 1-3 and pa
Lysophosphatidylcholine (LPC) has been attributed a pro-inflammatory role in atherosclerosis. Cell culture studies have identified stimulation of cytokine expression and chemotaxis by micromolar (muM) concentrations of LPC. In the present study we have investigated if LPC, in similarity with many other lipid mediators, has pro-inflammatory effects also at nanomolar (nM) concentrations. Cultured mo
OBJECTIVE: There is great need of biomarkers for research and clinical purposes in COPD. This study explored the relationships between ten putative plasma biomarkers of COPD and physiological measures of reduced lung function. METHODS: FEV(1), FVC, residual volume/total lung capacity (RV/TLC) and CO diffusion capacity (D(L)CO) were assessed in 357 subjects from the Swedish Twin Registry. The l
Guidance of eye-movements in image viewing is believed to be controlled by stimulus driven factors as well as viewer dependent higher level factors such as task and memory. It is currently debated to what proportions these factors contribute to gaze guidance, and also how they vary over time after image onset. Overall, the unanimity regarding these issues is surprisingly low and there are results
The measurement of subtle morphologic beat-to-beat variability in the electrocardiogram (ECG)/vectorcardiogram (VCG) is complicated by the presence of noise which is caused by, e.g., respiration and muscular activity. A method was recently presented which reduces the influence of such noise by performing spatial and temporal alignment of VCG loops. The alignment is performed in terms of scaling, r
We have shown previously that the stem cell factor (SCF) receptor undergoes phosphorylation on serine residues following ligand stimulation, and that this phopshorylation is dependent mainly on the activity of protein kinase C (PKC). In the present study, we have further investigated the molecular mechanisms behind SCF-stimulated activation of PKC, and found that SCF does not activate phosphatidyl
Controlled resistive loads can contribute to damping of electro-mechanical oscillations. This paper presents an on-off damping controller for a single machine system. It was used at a field test in southern Sweden to damp oscillations of a 0.9 MW hydro power generator. The controller used estimated machine frequency as input and controlled a 20 kW resistive load via thyristor switches. The field m
BACKGROUND AND AIM: The genetic basis of Metabolic syndrome (MetS) is largely unknown but a link with salt sensitivity is recognized. The cytochrome P450 isoform 4F2 (CYP4F2) is involved in renal production of 20-hydroxyeicosatethraenoic acid (20-HETE), a natriuretic substance associated with salt sensitivity. The same enzyme is implicated in ω-hydroxylation of very long and medium chain fatty aci
Objective: This study evaluates the effect of food intake on commonly used pulsed Doppler and tissue Doppler measurements. Methods: Twenty-three healthy subjects aged 25.6 ± 4.5 years were investigated. A wide selection of pulsed Doppler and tissue Doppler variables were measured before a standardized meal as well as and 30 and 110 minutes afterwards. Results: The following variables increased si
As the largest single energy-consuming component in most biological wastewater treatment systems, control of aeration is of great interest seen from an energy savings point of view. This paper suggests a simple way of using on-line ammonium measurements to control aeration in a pre-denitrification plant by controlling the dissolved oxygen setpoint. The controller works primarily by feed-forward ba
The social consequences of agrarian change have been widely debated. The traditional view of the lower classes becoming increasingly vulnerable due to the loss of access to resources has been met with the revisionist view that this change was counteracted by an increase in the volume and regularity of employment due to investments and new farming practices. This article address this issue by study
The serine protease tissue-type plasminogen activator (t-PA) is involved in both vital physiological brain processes, such as synaptic plasticity, and pathophysiological conditions, such as neurodegeneration and ischemic stroke. Recent data suggest that epigenetic mechanisms play an important role in the regulation of t-PA in human endothelial cells. However, there are limited data on epigenetic r
Popular Abstract in Swedish Utveckling av nya industriella produkter sker allt oftare med hjälp av datormodeller. Dessa modeller beskriver fysiken för respektive produkt, vilket exempelvis kan vara en bil eller ett kraftverk. Med hjälp av modellerna kan en stor del av analyserna på de framtida produkterna ske med hjälp av datorer, varför färre prototyper behöver konstrueras, vilket medför kortare Simulation of coupled dynamical systems, where the subsystems are bundled with their own internal solver, is important in industry. This is due to that in many cases, with complex systems, this is the only viable option. In this setting, the dynamics of each system is hidden and information between subsystems is exchanged through sampled inputs and outputs, a weakly coupled system. While a new ind
We consider realistic multiple input multiple output antenna systems operating over spatially colored channels with instantaneous, albeit imperfect, channel state information at the receiver and only covariance knowledge available at the transmitter. We focus on pilot-aided channel estimation in which the receiver uses minimum mean square error channel estimation. For such a setup, our goal is the
