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Serious outcomes as stroke, arrythmia and death are relatively frequent in patients presenting with dizziness. Within 30 days almost one in five patients re-attended the ED due to dizziness and 2,8% needed ED evaluation due to a fall. Decision support tools to help identify serious conditions and predict preventable falls in ED patients with dizziness are needed.
Fibrillar protein aggregates are a hallmark of a range of human disorders, from prion diseases to dementias, but are also encountered in several functional contexts. Yet, the fundamental links between protein assembly mechanisms and their functional or pathological roles have remained elusive. Here, we analyze the aggregation kinetics of a large set of proteins that self-assemble by a nucleated-gr
The refusal to shake hands with a female reporter by a Muslim politician from the Miljöpartiet resulted in a controversy in Sweden. Together with a number of court cases, it revealed a disparity between the established judicial line and the views of the general public. The Swedish controversy received a response from Denmark, where the ruling coalition introduced new citizenship legislation with a
Infusion of large amounts of intravenous immunoglobulin (IVIG) or anti-D can reverse the low platelet count in patients with ITP within hours of the initiation of treatment. In some cases, the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain these rapid and long term effects and these will be discussed in this review.
Interactions between immune cells such as T cells and antigen-presenting cells (APCs) are integral for mounting an adaptive immune response. The interaction between the T cell receptor (TCR) and the antigen-presenting major histocompatibility complex (pMHC) on a contacting T cell and APC, is widely accepted to be the key interaction. If the interaction is favourable, then T cell activation occurs.
Di-isobutylene has received significant attention as a promising fuel blendstock, as it can be synthesized via biological routes and is a short-listed molecule from the Co-Optima initiative. Di-isobutylene is also popularly used as an alkene representative in multi-component surrogate models for engine studies of gasoline fuels. However, there is limited experimental data available in the literatu
Iosipescu shear tests were performed at room temperature and at 316-°C (600-°F) on woven composites with either M40J or M60J graphite fibers and PMR-II-50 polyimide resin matrix. The composites were tested as supplied and after thermo-cycling, with the thermo-cycled composites being tested under dry and wet conditions. Acoustic emission (AE) was monitored during the room and high temperature Iosip
Countries worldwide have deployed mass COVID-19 vaccination drives, but there are people who are hesitant to receive the vaccine. Studies assessing the factors associated with COVID-19 vaccination hesitancy are inconclusive. This study aimed to assess the global prevalence of COVID-19 vaccination hesitancy and determine the potential factors associated with such hesitancy. We performed an organize
The need for increaseding accuracy and reduced ambiguities in the inversion results has resulted in focus on the development of more advanced inversion methods of geophysical data. Over the past few years more advanced inversion techniques have been developed to improve the results. Real 3D-inversion is time consuming and therefore often not the best solution in a cost-efficient perspective. This
Prostate-specific antigen (PSA) is a serine protease secreted by hath normal prostate glandular celts and prostate cancer cells. The major proteolytic substrates for PSA are the gel-forming proteins in semen, semenogelin (Sg) I and II. On the basis of the PSA cleavage map for Sg I and II, a series of small peptides (ie., ≤ 7 amino acids) was synthesized and coupled at the COOH terminus to 7-amino-
Legal tech is growing, and its growth provokes anxieties about the future of the legal profession as such. In this article, we examine the impact of legal tech on the central role of lawyers at law firms in crafting an imagined ‘right legal answer’ by drawing on Duncan Kennedy’s suggestion that a claim to the rightness of one’s legal propositions is a central characteristic of the legal profession
Future exemplary education should foster inclusive and respectful learning environments to meet new challenges like digital inequality and power concentration. In the new normal of education due to COVID-19, inclusive online disaster risk reduction (DRR) education is essential. Therefore, this article aims to investigate the current status quo of inclusive online and distance DRR education and its
High-pressure homogenizers are widely used in industrial processes to produce emulsions with small droplet sizes. During the process, cavitation occurs under industrial process conditions. In order to investigate the flow conditions inside a homogenizer geometry, CFD simulations are commonly used, since it is not possible to evaluate local flow conditions experimentally. However, these studies hav
An electron microscopy study of the new Bi-based high-temperature superconductor reveals an incommensurately modulated, pseudo-tetragonal, layered structure strongly reminiscent of the so-called Aurivillius phases. The systematic extinction conditions associated with the matrix and satellite reflections allow two possible space group symmetries for the average structure and two possible superspace
The chapter identifies several themes that are potentially significant in future research on Gen Z and sustainable tourism consumption. The need for cross-generational and cross-cultural research is identified, especially in a longitudinal context. It is also noted that the majority of research is undertaken in the developed world and the authors highlight the need for research in less developed c
Epidemics and pandemics are associated with a variety of life-threatening conditions and have serious effects on physical as well as mental wellbeing. The Covid-19 pandemic raised the same difficulties for public and private sectors including schools, businesses, healthcare sectors, etc. The disease, which originated in Wuhan, China in December 2019, has ravaged nearly every country in the world.
Systematic evaluations are vital to support learning and enhance performance in a crisis response. There are quantitative methods available today for evaluating crisis response management (CRM), but there are limiting factors negatively affecting their potential; They often involve techniques difficult to implement in real events, lack reliability testing, provide outcomes questionable from a lear
Over the past few decades, many studies of corruption have been carried out. These studies have mainly focused on specific aspects of corruption such as economic issues, legal issues, social propositions, national development and economic policy. This study builds a systems thinking model of corruption, which helps in the understanding of corruption and acts as an input into future policymaking on
