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OBJECTIVE: Treatments have failed to delay or stop the autoimmune process, preceding onset of type 1 diabetes. We investigated if autoantigen-specific treatment with alum-formulated glutamate decarboxylase (GAD-Alum) was safe and affected progression to type 1 diabetes in children with islet autoimmunity.METHODS: In an investigator-initiated, double-blind, placebo-controlled clinical trial, non-di
Different methods for treatment of leachate from a municipal solid waste (MSW) landfill were tested in a pilot plant. Raw leachate was pre-treated with aeration and sedimentation, followed by several parallel individual steps such as bioremediation, chemical oxidation, ozonation, and geo-bed filters. The efficiency of different treatment steps was evaluated according to one previously developed pr
An isochromosome of the long arm of chromosome 17, i(17q), is the most frequent genetic abnormality observed during the disease progression of Philadelphia chromosome-positive chronic myeloid leukemia (CML), and has been described as the sole anomaly in various other hematologic malignancies. The i(17q) hence plays a presumably important pathogenetic role both in leukemia development and progressi
The focus of this work is to characterize the mechanical stresses and fatigue along the enameled wire due to thermal expansion. The stresses and fatigue is estimated for a single wire and as a function of evenly distributed temperature. The estimation is based on both analytical equations and 3D Finite Element (FE) model. This characterization of mechanical stresses and fatigue is then used to exa
This study explores gender identity, vulnerability, and agency in the lives of smallholder farmers, within the context of climate variability in Ky Anh, Central Vietnam. The study first explores how gender identity and power is constructed within everyday rural practices. It then examines how men and women experience differential vulnerabilities in relation to changes such as climate variability.
Fractures of the distal radius in postmenopausal women may cause prolonged pain and disability, but little is known about their natural course beyond the first year. In this study, women of 50-75 years of age, initially treated with cast or external fixation, were examined 1 year after distal radial fracture and then re-evaluated after a mean of 3 (range, 2-4) years. The evaluation included pain,
With climate change unfolding, there is a need for adaptation policies that support the most vulnerable. Knowledge of the interconnection between adaptation policies and inequality is however limited, especially regarding power relations and institutional factors. Using data gathered in interviews with public officials and NGO representatives, this thesis explored the interaction of climate change
Capping and/or lamination occur as a result of low mechanical strength in tablets. The mechanical strength can be enhanced with suitable formulation- and process parameters for the tablet powder in question. The aim of the present thesis was to investigate capping tendencies of mannitol based tablets. More specifically, the effect of varied particle size of mannitol, type and concentration of bind
LUNDS UNIVERSITET KURSPLAN 1 A. SASA013 Introduktion i socialt arbete som forskningsämne, 7,5 högskolepoäng Doktorandkurs, Introduction in social work research, 7,5 higher education credits. Third cycle. Kursplanen är fastställd av Socialhögskolans institutionsstyrelse 2019-04-24. Denna kursplan träder i kraft höstterminen 2019. B. Allmänna uppgifter Kursen är en obligatorisk kurs inom ramen för F
https://www.soch.lu.se/sites/soch.lu.se/files/kursplan_sasa013_190424.pdf - 2026-07-23
Thesis purpose: This thesis aims to discover young Swedish consumers' boycott and buycott behavior of food and drink brands by understanding their decisions and participation in these practices. Methodology: This study is built upon a qualitative research design and adopts an abductive approach. A social constructionist viewpoint guides the research to help to get a deeper understanding of yo
In recent years, international development projects have been increasingly working on LGBTI inclusion in sub-Saharan Africa. This study explores how international HIV/AIDS projects with key population components have contributed towards LGBTI inclusion in Angola by analysing the possible challenges and synergies between those projects in the period 2015-2020. This exploratory research combines a d
Sweden has received a high number of immigrants during the last decade. This has led to an increased ethnic and socioeconomic segregation in Swedish cities, which in turn has led to different integration initiatives to become more frequent. This thesis aims to investigate how a “buddy programme”, a social integration project that matches a newcomer and an established Swede together, can enrich the
The aim of this essay is to study the key characteristics of the Bildungsroman and examine if the same traits still are in use in contemporary fiction and what values that are being mediated. The aim is also to focus on the style in which the pedagogical message is being delivered thus highlighting the possible differences and similarities between an old-fashioned Bildungsroman, Charles Dickens’ G
Sida 1 av 18 Postadress 221 00 Lund, Besöksadress Arkeologen Sandgatan 1 Telefon 076-130 35 66, 046-222 00 00, E-post ingegerd.wirehed@rektor.lu.se BESLUT Diarienummer STYR 2022/587 Datum 2022-03-24 Rektor Ledningssystem för informationssäkerhet vid Lunds universitet Fastställt av rektor 2022-03-24 mailto:ingegerd.wirehed@rektor.lu.se Sida 2 av 18 Postadress 221 00 Lund, Besöksadress Arkeologen Sa
To evaluate the performance of dried blood spots (DBSs) with subsequent analyses of glutamic acid decarboxylase (GADA) and islet antigen-2 (IA-2A) with the RSR-ELISAs, we selected 80 children newly diagnosed with type 1 diabetes and 120 healthy women. DBSs from patients and controls were used for RSR-ELISAs while patients samples were analysed also with in-house RIAs. The RSR-ELISA-GADA performed
Background: Season of birth has been associated with age at menarche. Maternal vitamin D levels in pregnancy may explain this effect. We investigated whether the season of first trimester or maternal 25-hydroxyvitamin D3 [25(OH)D3] levels were associated with pubertal timing in children. Methods: We conducted a follow-up study of 15 819 children born in 2000-03 from the Puberty Cohort, nested in t
Randomised controlled trials conducted using cohorts and routinely collected data, including registries, electronic health records and administrative databases, are increasingly used in healthcare intervention research. A Consolidated Standards of Reporting Trials (CONSORT) statement extension for trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE) has been developed with
INTRODUCTION: Height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the BRCA1 or BRCA2 genes.PATIENTS AND METHODS: An international pooled cohort of 8091 BRCA1/2 variant carriers was used for retrospective and prospective analyses separately for prem
