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Contractile injection systems (CISs) are phage-tail-like nanosyringes that mediate bacterial interactions by puncturing target cell membranes. Within these systems, Photorhabdus Virulence Cassettes (PVCs) can translocate toxins across eukaryotic target cell membranes. The structure of a PVC has been described at atomic level and engineered to deliver diverse protein cargoes into non-natively-targe
In this paper we study the evolution of radiative fluxes, flux radii and observable dust masses in protoplanetary discs, in order to understand how these depend on the angular momentum budget and on the assumed heat sources. We use a model that includes the formation and viscous evolution of protoplanetary gas discs, together with the growth and radial drift of the dust component. We find that we
Introduction: Epidemiological studies on elite female ice hockey players are lacking but needed to tailor preventive efforts in this growing group of athletes. Therefore, the aim of this study was to describe the incidence, prevalence, and burden of health problems in elite female ice hockey players. Methods: In this prospective cohort study, we asked all Swedish Women's Hockey League (SWHL) playe
Purpose: The aim of this study was to evaluate risk factors for postoperative pain and nausea after open repair for primary ventral hernias. Method: A population-based registry study was conducted based on data assembled from the Swedish national ventral hernia repair register between January 2016 and December 2021and cross-matched with the Swedish perioperative register. Results: Altogether 2064
This paper examines how India’s national urban development agenda is reshaping relationships between national, State and city-level governments. Jawaharlal Nehru National Urban Renewal Mission, the flagship programme that heralded a new era of urban investment in India, contained a range of key governance aspirations: linking the analysis of urban poverty to city-level planning, developing holisti
Expanded state-subsidised housing programmes in middle-income countries raise questions about the displacement and socio-spatial marginalisation of poor households. Examining these questions through people’s experiences of resettlement indicates the importance of mobility to their lives. Drawing on a mixed-method comparative study of Ahmedabad, Chennai and Johannesburg, we ask: How does the reloca
Objective: Exercise is a first-line intervention for osteoarthritis (OA). However, exercise adherence remains low, and existing studies exploring factors influencing adherence have yielded inconclusive results based on quantitative data. This study aims to synthesise qualitative studies focused on the perceived facilitators and barriers affecting exercise adherence in individuals with OA. Design:
Water flows through time are connected to specific instances of socionatural and sociotechnical assemblages of human and non-human components. We propose the concept of “water palimpsest” in order to characterize the complex histories of chemical and metabolic alterations embodied in water flows, potentially disruptive for humans and other living beings. Through the concept of palimpsest we interp
Women have always played a central role in smallholder agriculture in many farming systems of the Global South. However, they have had, and still have, low access to agricultural information, and even less ability to enact on training or advice received, in comparison to male farmers. The paper investigates what is needed for female smallholders to better benefit from agricultural advice and train
Uveal melanoma (UM) is a rare but frequently metastasizing cancer. Genome-wide association studies have identified three common genome-wide significant germline risk loci. Here, we perform a genome-wide association study on 401 new cases and conduct a meta-analysis with three independent previously published cohorts for a total sample size of 2,426 cases. We confirm the three previously identified
Environmental communication often abstains from irony because of the perceived negative effects on audiences. However, these views are increasingly challenged, and the frivolous term “bad environmentalism” has been adopted to question the prevailing conceptions of irony as unsuitable for environmental communication. Yet, little is known about this affective genre. Additionally, existing studies of
E-poster, 2-minute presentation Statement of Problem Self-generated mobility, defined as the capacity for independent movement, plays a critical role in early childhood development. Limited mobility, often associated with conditions like cerebral palsy or muscular dystrophy, poses significant developmental delays, particularly impacting physical, social, and cognitive growth. Description of the Co
Molecular subtyping of pulmonary large-cell neuroendocrine carcinoma (LCNEC) based on retinoblastoma protein (pRb) expression may influence systemic treatment decisions. Current histomorphologic assessments of hematoxylin and eosin–stained tissue samples cannot reliably differentiate LCNEC molecular subtypes. This study explores the potential of deep learning (DL) to identify histologic patterns t
This study explores socioeconomic disparities in how patients trade off quality against other features when choosing their primary care provider. We use a unique registry dataset linking the choices of individuals who recently moved to a new market, and therefore need to select a new provider, with detailed individual-level measures of socioeconomic status (SES) and provider-level measures of pati
Introduction: The climate and biodiversity crises are interconnected, unprecedented, existential threats that cause disturbing emotions, such as anxiety, grief, and anger. While there is increasing research about antecedents and outcomes of such eco-emotions, less is known about how to cope with them constructively, to benefit both mental health and pro-environmental action. Objectives: This study
TOI-1266 is a benchmark system of two temperate (<450 K) sub-Neptune-sized planets orbiting a nearby M dwarf exhibiting a rare inverted architecture with a larger interior planet. In this study, we characterize transit timing variations (TTVs) in the TOI-1266 system using high-precision ground-based follow-up and new TESS data. We confirm the presence of a third exterior nontransiting planet, TOI-
We investigated the molecular mechanisms of exercise adaptations in human muscle by integrating genome, methylome, transcriptome, and proteome data from over 1,000 participants (2,340 muscle samples). We identified distinctive signatures associated with maximal oxygen consumption (VO2max), and multi-omics integration uncovered five key genes as robust exercise markers across layers, with transcrip
Aedes albopictus, a key vector for Dengue, Chikungunya, Zika, and Yellow Fever, is expanding its range beyond its tropical and subtropical origins, driven by suitable climate, population mobility, trade, and urbanization. Since its introduction to Europe, Ae. albopictus has rapidly spread and triggered recurrent outbreaks. Past model attempts have handled vector suitability and vector introduction
Japan’s rich archaeological record, supported by well-established chronological and typological frameworks, offers valuable opportunities to investigate prehistoric socio-cultural responses to climate change, although comprehensive studies remain limited. This exploratory paper examines the impact of climatic disruptions—particularly the 8.2 ka event—on Jomon foragers in Kyushu, aiming to develop
