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RATIONALE AND OBJECTIVES: We wanted to improve determination of the glomerular filtration rate (GFR) with plasma clearance techniques because the alternative-renal clearance techniques-may involve inaccurate urine sampling or risk of urinary tract infection when bladder catheterization becomes necessary. Therefore, we compared the renal and plasma clearances of iohexol and chromium-51-ethylenediam
Brain-derived neurotrophic factor (BDNF) is involved in brain plasticity and neuronal survival. Generally, BDNF enhances synaptic activity and neurite growth, although the effect of BDNF on neuronal survival and brain plasticity following injury is equivocal. Housing rats in an enriched environment after experimental stroke enhances recovery of sensory-motor function, which is associated with a de
The lysosomal cysteine proteinase cathepsin B is shown to be secreted by ten human colon carcinoma cell lines and to accumulate in culture media as a latent enzyme. The cell lines also secrete a physiological inhibitor of cathepsin B, cystatin C. A significant correlation was found between secretion of the latent enzyme and the inhibitor (r = 0.755, P < 0.01). The aim of the present study was to m
Membrane type 1-matrix metalloprotease (MT1-MMP or MMP-14) is a major activator of pro-MMP-2 and is essential for skeletal development. We show here that it is required for branching morphogenesis of the submandibular gland but not the lung. Instead, in the lung, it is essential for postnatal development of alveolar septae. Lung development in Mmp14-/- mice is arrested at the prealveolar stage wit
The use of radio-labeled somatostatin analogs, such as 177Lu-labelled DOTATATE, in PRRT, has based on the studies performed until now, shown to be promising for RNT disseminated neuroendocrine tumors [1]. In this regard, the aim of treatment is to assure the delivery of the highest possible absorbed dose to the tumor cells, while saving the normal tissues [1], meaning, to achieve a higher activity
By addressing an absence of implementation studies, this master thesis aims to examine the implementation of the FRESH health policy in schools in Lombok, Indonesia. The method used is a qualitative field study based on empirical material consisting of interviews with representatives from implementing organizations and teachers designated to be “FRESH coordinators” in schools. By utilizing dimensi
Sub-micrometer atmospheric aerosol particles were studied in the Amazon region, 125 km northeast of Manaus, Brazil (-1degrees55.2'S, 59degrees28.1'W). The measurements were performed during the wet-to-dry transition period, 4-28 July 2001 as part of the LBA (Large-Scale Biosphere Atmosphere Experiment in Amazonia) CLAIRE-2001 (Cooperative LBA Airborne Regional Experiment) experiment. The number si
We compared three different molecular methods currently used for screening of Mhc variation in population studies of Atlantic salmon. Restriction fragment length polymorphism (RFLP) of the entire class II gene detected 22 haplotypes. Seventeen exon 2 sequences were obtained from individuals carrying the 22 haplotypes, two of which had not been detected by RFLP. The six alleles (27%) detected by RF
Fatty acid analysis was used for determining the extent of the development of the external mycelium of AM fungi (mixed inoculum from a sand dune) growing from roots of Festuca rubra and Plantago lanceolata in calcareous dune sand. The plants were raised in chambers specially designed to permit the growth of AM mycelium in root-free compartments. In two separate experiments, growth of external myce
Systemic lupus erythematosus (SLE) is the prototype autoimmune disease where genes regulated by type I interferon (IFN) are over-expressed and contribute to the disease pathogenesis. Because signal transducer and activator of transcription 4 (STAT4) plays a key role in the type I IFN receptor signaling, we performed a candidate gene study of a comprehensive set of single nucleotide polymorphism (S
The root/organic soil concentration ratio; R/S) of 50 cationic mineral elements was related to their ionic properties, including ionic radius (r), ionic charge (z), and ionic potential (z/r or z(2)/r). The materials studied were ectomycorrhizal beech (Fagus sylvatica L.) roots and their almost purely organic soil substrate, the O-horizon (mor; raw humus) of a Podzol in South Sweden, developed in a
Context. To study the evolution of Li in the Galaxy it is necessary to observe dwarf or subgiant stars. These are the only long-lived stars whose present-day atmospheric chemical composition reflects their natal Li abundances according to standard models of stellar evolution. Although Li has been extensively studied in the Galactic disk and halo, to date there has only been one uncertain detection
Aim: To investigate the effect of general anaesthesia on the TCI-dosage, the depth of anaesthesia and the need for hemodynamic treatment. A comparison between general anaesthesia (GA) alone and general anaesthesia combined with epidural anaesthesia (GA+EDA). Background: There are some uncertainties in the literature whether epidural anaesthesia has any effect on general anaesthesia governed by Ta
The conditions for trading differ in the EU, even though the idea of the single market was born almost six decades ago and started to go toward completion over two decades ago. These differences causes asymmetry in trade costs which lead to trade volumes, and in extension wealth, are less in the union than what they would be if the union was more harmonized. This paper is therefore aiming at findi
Background and aims: We examined whether the excess cardiovascular disease (CVD) risk among adults with steatotic liver disease (SLD) subtypes could be reduced or eliminated through joint control of low-density lipoprotein cholesterol (LDL-C), lipoprotein(a) [Lp(a)], and high-sensitivity C-reactive protein (hs-CRP). Methods and results: This prospective cohort study included 291,995 participants f
Development, where agriculture is a central component, is today often related to different aspects of sustainability. Sustainable development is argued to be most effective when implemented on a local level where non-governmental organisations (NGOs) are usually active agents. The implementation of sustainable practices, such as sustainable agriculture, could hence be argued to depend upon the eff
This study explains why Sexual and Reproductive Health (SRH) among youths continuously pose challenges in the Lusaka area of Zambia, despite multiple Non-Governmental Organizations (NGOs) targeting this. An embedded case study design was applied and staff and youths engaged in NGOs working with youths’ SRH were main informants. The Social Ecological Theory was applied to widen the approach of prev
The thesis departures from concepts from conflict transformation and resolution literature and peace research in order to analyse the situation in the Northern Region of Ghana and establish the possibilities of work for the Commission on Human Rights and Administrative Justice in the Northern Region. Further, the Paris Principles are studied and the basis for work of national human rights institut
