Filtyp
Collagen-induced arthritis (CIA) is a well studied mouse model of the human disease rheumatoid arthritis (RA). Both CIA and RA are complex diseases affected by multiple genes as well as environmental factors. Identifying the genes that determine susceptibility to arthritis would give invaluable clues to the largely unknown aetiology of RA. In this study, we dissected a known locus, Cia6, as well a
Seed particles of elements or compounds which may or may not form alloys are now used extensively in promoting well-controlled nanowire growth. The technology has evolved following the well-known Vapour-Liquid-Solid (VLS) model which was developed over 40 years ago. This model indicates that a liquid alloy is formed from the seed particle and the growth precursor(s), resulting in crystal growth by
Objectives. Venous thromboembolism (VTE) is a potentially serious complication of hospitalization and immobilization. The use of anticoagulant prophylaxis in acutely ill medical inpatients is still under debate. New data including a recent meta-analysis have recently been published. We aim at studying the efficacy and safety of anticoagulant prophylaxis in acutely ill medical inpatients, and demon
Popular Abstract in Swedish Undertrycksbehandling av sår, på engelska negative pressure wound therapy (förkortat NPWT) är en teknik som används vid behandling av svårläkta akuta och kroniska sår. Med hjälp av NPWT läker vissa typer av sår mycket snabbare än vid traditionell sårbehandling. I bildtexten på nästa sida ges en kort beskrivning av hur metoden fungerar. Tekniken utvecklades i slutet av 1NPWT has recently been associated with severe complications and bleeding when used in wounds with exposed blood vessels. The aims of this work were to investigate the mechanisms of action of NPWT and to explore the possibility of using thin plastic discs to protect exposed blood vessels in the wound bed during NPWT. Three different kinds of wounds were created in pigs: 6 cm and 10 cm diameter circ
Development of B-lymphoid cells in the bone marrow is a process under strict control of a hierarchy of transcription factors. To understand the development of a B-lymphoid-restricted functional network of transcription factors, we have investigated the cell autonomous role of the transcription factor EBF1 in early B cell development. This revealed that even though transplanted EBF1-deficient fetal
Introduction: Equity in access to and utilization of health services is a common goal of policy-makers in most countries. The current study aimed to evaluate the distribution of need and access to health care services among Iran's rural population between 2006 and 2009. Methods: Census data on population's characteristics in each province were obtained from the Statistical Centre of Iran and Natio
Objective. The enteric microbiota is a pivotal factor in the development of intestinal inflammation in humans but probiotics, dietary fibres and phytochemicals can have anti-inflammatory effects. The aim of this study was to evaluate the therapeutic effect of multi-strain probiotics and two conceivable prebiotics in an experimental colitis model. Material and methods. Sprague-Dawley rats were fed
Patients and methods: Participants completed the Hospital Anxiety and Depression Scale and two subscales, Vitality and Mental Health, in the SF-36 4-8 weeks (T1) (n = 61), 6 (T2) (n = 57), 12 (T3) (n = 50), and 18 (T4) months (n = 48) after diagnosis. I-State as Object of Analysis was used to identify a finite set of states based on three dimensions. Cluster analysis was carried out using Ward's m
In vivo gene transfer using viral vectors is an emerging therapy for neurodegenerative diseases with a clinical impact recently demonstrated in Parkinson's disease patients. Recombinant adeno-associated viral (rAAV) vectors, in particular, provide an excellent tool for long-term expression of therapeutic genes in the brain. Here we used the [C-11] raclopride [(S)-(-)-3,5-dichloro-N-((1-ethyl-2-pyr
This thesis aimed to search for epidemiological evidence supporting the associations of type 2 diabetes mellitus (T2DM) with cancer and autoimmune diseases (ADs) by analysing several Swedish national registries. T2DM shares risk factors with cancer, such as obesity, diet, stress, and physical inactivity. However, it is unclear whether the associations with several types of cancers are due to share
Systemic lupus erythematosus (SLE) is an autoimmune disease involving many organ systems. The cause is not known, but a complex combination of environmental and genetic factors seems to be involved. In SLE upregulation of type I interferons, a hyperactive B-cell response, presence of autoantibodies against modified nuclear components, increased complement consumption, increased apoptosis and decre
Eae5 in rats was originally identified in two F-2 intercrosses, (DA x BN) and (E3 X DA), displaying linkage to CNS inflammation and disease severity in experimental autoimmune encephalomyelitis (EAE), respectively. This region overlaps with an arthritis locus, Pia4, which was also identified in the (E3 X DA) cross. Two congenic strains, BN.DA-Eae5 and BN.DA-Eae5.R1, encompassing the previously des
We studied electrophysiological properties of single chemosensory neurons in the mouthparts of the spiny lobsters Panulirus argus and Panulirus interruptus to complement our growing understanding of the behavioral roles of mouthparts of decapod crustaceans. Food mixtures and 13 single compounds were used to characterize the response specificity, sensitivity, and time course of individual neurons i
The purpose of this thesis is to provide insight into the recruitment and selection processes of high-tech companies in China and to advice returning Chinese overseas students on these recruitment and selection processes. We collected empirical data from respondents by using semi-structured interviews for the following qualitative analysis. Interview guide, selection of respondents, conduction of
Previous research has found clear spatial patterns of agricultural supply, both in pre-industrial Europe (Grantham 1978; Grantham 1989; Kopsidis 2009) and in the less developed countries of today (Benziger 1996; Stifel & Minten 2008). The spatial structure of farming intensity is mainly attributed to the declining net-returns with the distance from the market. This paper examines the impact of
This thesis provides a formal analysis of Agnès Varda’s documentary The Beaches of Agnès (2008), focusing on how the formal elements in the film such as voice-over, reenactments and the use of mirrors create a sense of self-awareness in the film. Through Agnès Varda’s extensive body of work it is possible to see the historical movement of the essay film, from its relation to the French Cinema fro
England har i dagsläget beslutat att ej anta den förslagna EU- förordningen om behörighet, tillämplig lag, erkännande och verkställighet av domar och officiella handlingar i samband med arv och om inrättandet av ett europeiskt arvsintyg. England deltar dock i de pågående förhandlingarna mellan medlemsstaterna rörande förordningen och en ratificering är fortfarande möjlig. Enligt England omfattar hTo date England has decided not to opt into the proposed EU Regulation on jurisdiction, applicable law, recognition and enforcement of decisions and authentic instruments in matters of succession and the creation of a European Certificate. However, with an eventual opt in England fully engages with the ongoing negotiations on the proposed Regulation between the Member States. From the English view
Using qualitative interviews with twenty recent graduates, this study explores how participants understand and experience career in the aftermath of the crisis. Overall, this study suggests that several dominant theories and practical storylines surrounding notions of career and career development present a static view that fails to take important contexts into account. We aim to provide a deeper
Populärvetenskaplig sammanfattning: Conodonter är stratigrafiskt användbara, fosfatiska mikrofossil, som påträffas i marina sediment mellan senkambrium till slutet av trias (520-210 Ma). Olika formtyper av conodonter, eller conodontelement, byggde tillsammans upp käkapparaten hos det lilla ål-liknande conodontdjuret, som numera räknas till chordaterna. Jag har undersökt förekomsten av conodontsläkSeven taxa of the conodont genus Ctenognathodus (Fay, 1959) sensu Viira, 1982b in the Silurian of Gotland have been described and their occurrence mapped geographically, stratigraphically and related to facies. In addition to C. murchisoni (Pander, 1856) three new species were found; C. n. sp. D, C n. sp. E and C n. sp. I with two subspecies, I and G. Two taxa formerly known as subspecies of Ligon
This study examines fuel use and metabolism in a group of long-distance migrating birds, red knots Calidris canutus (Scolopacidae), flying under controlled conditions in a wind tunnel for up to 10 h. Data are compared with values for resting birds fasting for the same time. Plasma levels of free fatty acids, glycerol and uric acid were elevated during flight, irrespective of flight duration (1-10h
