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The understanding of small cell lung cancer (SCLC) biology has increased dramatically in recent years, but the processes that allow SCLC to progress rapidly remain poorly understood. Here, we advocate the integration of rapid autopsies and preclinical models into SCLC research as a comprehensive strategy with the potential to revolutionize current treatment paradigms.
This chapter discusses Ilia Repin’s court commission, Reception of Volost Elders by Alexander III in the Courtyard of the Petrovsky Palace in Moscow (1886). It argues that the painting reflected marginalizing discourses on the non-Russian minorities dominant at the outset of Alexander III’s rule. Repin employed a differentiating approach to rendering ethnically and religiously diverse representati
A novel anisotropic ductile damage model at finite strains is proposed in this work. The model is formulated based on the fictitious configuration concept and includes deformation induced evolution of anisotropic damage properties. As a key contribution, different effective driving forces for both, plasticity and damage are elaborated in the context of a so-called two-surface formulation, i.e. the
This resource is a disaster risk financing conceptual framework to assist humanitarian donors, practitioners, and their partners (governments, local communities, etc.) to develop and implement more effective disaster risk financing activities.
There is currently considerable interest in producing new materials with extreme combinations of mechanical properties such as high hardnesses and moduli. One example of such a material is crystalline C3N4, which has been predicted to have a bulk modulus higher than that of diamond. In this paper we report on experiments carried out to synthesize CNx thin films. The films were grown in an unbalanc
Metal halide perovskites (MHPs) have garnered significant interest as promising candidates for nanoscale optoelectronic applications due to their excellent optical properties. Axially heterostructured CsPbBr3-CsPb(Br(1-x)Clx)3 nanowires can be produced by localized anion exchange of pregrown CsPbBr3 nanowires. However, characterizing such heterostructures with sufficient strain and real space reso
Aims This study aimed to test whether seismocardiography (SCG) can detect changes in loading conditions and detect significant differences in SCG signals between healthy individuals and those with cardiovascular disease (CVD). Methods Twenty-six subjects (age 45 ± 16 years and 77% male) were included, 11 healthy subjects and 15 subjects with CVD. SCG and results was compared with transthoracic ech
Work and working conditions are fundamental social determinants of health. Climate change poses an urgent and growing threat to workers' health, through both direct exposure to environmental hazards and indirect exacerbation of social and health inequalities. Occupational health, which focusses on the promotion of mental and physical health and well-being of workers, is a key but often overlooked
Proton Beam Therapy (PBT) is an increasingly utilised modality for treating tumours by utilising the physical properties of accelerated proton beams. This review explores the development of PBT, its dosimetric advantages over conventional x-ray-based radiotherapy, and the rationale behind its use in paediatric oncology whilst simultaneously considering the various challenges associated with its de
The thesis explores the migration experiences of Syrian refugees who arrived in Sweden and Denmark by crossing the Mediterranean Sea in small, precarious boats. It aims to illuminate how these refugees managed the risks they faced during their journey to Europe and the meanings they associated with these risks. The research focuses on the socio-cultural and individual contexts within which risk is
Introduction:Fava beans are becoming an increasingly popular and viable crop, offering a nutritious option for innovative plant-based food products. Despite their potential, fava beans remain underutilized in the food industry, with their primary use still being as animal feed [1]. However, fava beans are an interesting base material for producing plant-based milk alternatives. While soy milk curr
The aviation industry's decarbonization requires sustainable aviation fuel (SAF) feedstocks that do not compete with food resources. In this context, black soldier fly larvae (BSFL) lipids represent a non-food, second-generation feedstock with strong potential for drop-in SAF production. This work presents an integrated evaluation of BSFL-derived lipids hydroprocessed over a commercial Ce/La-doped
BACKGROUND: Frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominant atrophy is an emerging area of interest. Recent findings by the International Working Group (IWG) have identified this subtype as having a distinct clinical profile within the FTD spectrum (Ulugut et al., 2024, A&D). However, its genetic and pathological underpinnings remain unexplored in large, mult
Natural salts are minerals formed through natural processes, generally consisting of complex mixtures of ions. In the atmosphere, natural salts are present as aerosol particles, originating from both marine and terrestrial sources. The interaction of these natural salt particles with trace gases, also termed ageing, can influence various atmospheric processes such as cloud properties or atmospheri
BACKGROUND: The occurrence of migratory takeoff behavior is the essential first step for long-distance migration of insects. However, its characteristics, frequency of occurrence, and the identity of environmental and physiological factors influencing this process remain largely unknown. RESULTS: We investigate the global pest fall armyworm (FAW, Spodoptera frugiperda) as an exemplar species to in
Celiac disease etiopathogenesis requires genetic predisposition and exposure to gluten, yet these factors alone are not sufficient. Larger longitudinal studies are needed to determine the role of time-varying infections and gut microorganisms. The aim was to design a celiac disease case-cohort longitudinal study using The Environmental Determinants of Diabetes in the Young (TEDDY) study. By age 3-
Over the years, demand-responsive transport (DRT) and similar concepts have been implemented and tested in different environments and in different configurations. However, many of these transport services have been abandoned, for various reasons. Previous research shows that some of the most important success factors for a DRT service to sustain over the years are low-cost solutions adjusted to a
—Methods for estimating radiological consequences in terms of radiation doses and cancer risks are needed for informed decisions on mitigation efforts after a radionuclide event. The 1986 Chernobyl Nuclear Power Plant accident fallout in Sweden was used as a case study. Open-source data on annual sex-specific population data in 1-y classes by municipality (n = 290), counties (n = 21), and future p
