Filtyp
PURPOSE: To compare absolute cerebral blood flow (CBF) estimates obtained by model-free arterial spin labeling (ASL) and dynamic susceptibility contrast MRI (DSC-MRI), corrected for partial volume effects (PVEs). METHODS: CBF was measured using DSC-MRI and model-free ASL (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) at 3 T in 15 subjects with brain tu
Enteroendocrine cells such as duodenal cholecystokinin (CCK cells) are generally thought to be confined to certain segments of the gastrointestinal (GI) tract and to store and release peptides derived from only a single peptide precursor. In the current study, however, transgenic mice expressing enhanced green fluorescent protein (eGFP) under the control of the CCK promoter demonstrated a distribu
Recent findings have indicated that tyrosine kinase inhibitors (TKIs) targeting the ERBB receptor family display anti-leukaemic effects, despite the lack of receptor expression on human leukaemic cells. The occurrence of activating mutations in the gene encoding FMS-like tyrosine kinase 3 (FLT3) in patients with acute myeloid leukaemia (AML) has rendered inhibition of this receptor a promising the
In the course of a few months in 1997, about 20 per cent of Stockholm Stock Exchange's primary-list firms transferred to the Exchange's secondary list due to a new tax policy. Drawing on a theory of social influence, we suggest that the transfer decisions depended both on the firms' social embeddedness with other firms in the population at risk and their economic predisposition to make such transf
Aim: The aim of this study was to determine if innate immune signalling influences the vascular repair process in response to mechanical injury of arteries in mice. Methods and Results: A non-obstructive collar was introduced around the carotid artery of MyD88-deficient mice and neointima formation was compared to that observed in MyD88-competent mice. MyD88-deficient mice are characterized by imp
MicroRNAs are central players in the control of insulin secretion, but their transcriptional regulation is poorly understood. Our aim was to investigate cAMP-mediated transcriptional regulation of the miR-212/miR-132 cluster and involvement of further upstream proteins in insulin secreting β-cells. cAMP induced by forskolin+IBMX or GLP-1 caused increased expression of miR-212/miR-132, and elevated
Indoor air measurements were conducted in one unoccupied apartment of a ‘near-zero-energy’ residential building with a unique, wooden construction. Ozone, NO2, fine particles and volatile organic compounds, formaldehyde, acetaldehyde and peroxyacetyl nitrate (PAN) were measured under ‘as is’ conditions and after intentional intervention by adding ozone to simulate an ambient air ozone episode. Und
Previous studies on lymphocytes have suggested that patients with head and neck squamous cell carcinoma (HNSCC) have an increased susceptibility for chromosomal damage induced by bleomycin, a known radiomimetic mutagen. However, it has so far not been possible to study whether this genetic instability is present also in the epithelial component of the upper aerodigestive tract mucosa, the tissue f
A novel application of cellobiose dehydrogenase (CDH) as sensing element for a Bioelectronic Tongue (BioET) system has been tested. In this work CDHs from various fungi, which exhibit different substrate specificities, were used to discriminate between lactose and glucose in presence of the interfering matrix compound Ca(2+) in various mixtures. This work exploits the advantage of an electronic to
The relationship between tumour necrosis factor-alpha (TNF-α) and drug survival had not been studied in juvenile idiopathic arthritis (JIA) and there were no laboratory tests to predict the long-term efficacy of biological drugs for JIA. We studied if serum levels of TNF-α, free or bound to etanercept, could predict long-term efficacy of etanercept in children with JIA.
Problem/ Background: The study leans on nationalism and globalization debate in the schools of cultural studies and feminist sociological research. The study discusses how gender is constructed in frames of nationalist projects and identity. We concentrate on the situation in Finland in the late 1990s. The question is examined through application of discourse analysis, focused on narratives of thr
The question of international peace and security today includes far more than merely weapons and balance of power. The cold war conception of state security with primary focus on external aggression failed to offer adequate protection against the everyday threats facing the people of the world - threats that often are more tangible than a looming threat of war. Entrusted with the responsibility fo
The Convention on the Rights of the Child is a legal framework stating what rights children have. Street children also have all these rights but few countries have responded to this. The Convention is however the most widely ratified multi-national treaty in existence and have been ratified by all countries known to deprive street children of their rights. This Master thesis uses the situation in
This thesis examines the definition of the term 'self-contained regime', a term firstly used by the International Court of Justice in the Tehran Hostages Case and since then discussed and analyzed by international scholars of international law. The term has been used to label a treaty or set of treaties in international law that set up a system of norms that to some extent exclude the appl
My graduate thesis handles the problem how Sony Ericsson Mobile Communications AB (SEMC) in the easiest way can establish a market in the south of India, Chennai, relating to accessories. The most relevant accessory that they want to manufacture is portable hands frees. I have made an analysis of financial and governmental directives and found out what the restrictions are to import and export goo
As an equality producing mechanism Martha Nussbaum presents a list of ten central human capabilities which, if realised, will lead to a dignified life. The purpose of this thesis is to discover if it is reasonable to suggest that Nussbaum’s list of central human capacities equates to a unified definition of dignity. By examining the parallels between the Poverty Reduction Strategy Papers (hereafte
