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Objectives: To investigate the predictive value of cystatin C among patients diagnosed with non-ST-elevation acute coronary syndrome (nSTE-ACS). Design and methods: Admission serum samples from 245 nSTE-ACS patients were measured with a novel cystatin C immunoassay based on a dry-reagent, double monoclonal design. Creatinine concentrations, estimated glomerular filtration rates (eGFR) and one-year
Variations in health between neighborhoods are well known and the conceptualization of social capital has contributed to an understanding of how contextual factors influence these differences. Studies show positive health-effects from living in high social capital areas, at least for some population sub-groups. The aim of this qualitative study was to understand what constitutes a 'health-enabling
Wheat flour and cane sugar were partially substituted (50 and 75%) by a mango-processing by-product (MPB) as an added-value food ingredient in muffins. Their sensory analysis, chemical composition, antioxidant activity and in vitro starch hydrolysis properties were studied. Sensory analysis showed statistically significant difference (p < 0.05) between control and muffins 75% MPB substituted level
Apicidin is a potent histone deacetylase inhibitor (HDACI) that selectively binds to histone deacetylases (HDACs) class I and interferes with the deacetylation process, which results in modification of acetylation level of cellular proteins. The aim of the study was to investigate the potential time and dose dependent cytotoxicity of the test compound, Apicidin, in pancreatic cancer cells Capan-1
Two-dimensional polarization fluorescence imaging of single light harvesting complexes 2 (LH2) of Rps. acidophila was carried out to investigate the polarization properties of excitation and fluorescence emission simultaneously, at room temperature. In two separate experiments we excited LH2 with a spectrally narrow laser line matched to the absorption bands of the two chromophore rings, B800 and
Abundant chromite grains with L-chondritic composition in the resurge deposits of the Lockne impact crater (458 Myr old: dia. similar to 10 km) in Sweden have been inferred to represent relict fragments of an impactor from the break-up of the L-chondrite parent body at 470 Ma. This view has been challenged based on It/Cr and platinum group element (PGE) patterns of the same resurge deposits, and a
This paper concerns the operational activities of the public security organs of the People’s Republic of China (PRC) during the immediate post-1949 period of regime consolidation. The main part of the paper is a case-study of a 1950 pilot scheme to recruit agents in critical sectors of industry and trade in the city of Yingkou in Northeast China, a scheme in due course subsumed under a nationwide
Anaplasma platys was first identified and described in North America as a Rickettsia-like, platelet-specific organism in dogs with infectious canine cyclic thrombocytopenia. In Europe, A. platys has so far mainly been described for some Mediterranean countries. Here, we describe a case of A. platys infection in a dog from Romania, confirmed by PCR. Additionally, the dog had a co-infection with Hep
This study deals with the historian Jan T Gross’ book Fear, published in 2006 in the United States and in 2008 in Poland. The book deserves special attention because it became one of the most discussed historical works in post-Communist Poland. In Fear, just as in his previous book Neighbors (2000), Gross challenged the Poles’ view of themselves as solely innocent victims of German Nazism and argu
Current management of hemophilia B entails multiple weekly infusions of factor IX (FIX) to prevent bleeding episodes. In an attempt to make a longer acting recombinant FIX (rFIX), we have explored a new releasable protraction concept using the native N-glycans in the activation peptide as sites for attachment of polyethylene glycol (PEG). Release of the activation peptide by physiologic activators
Colostrum is an indispensable source of antibodies (IgG) protecting the newborn pig against infection. We studied the effect of feeding colostrum and purified IgG on early structure and development of the gastrointestinal tract (GIT). Newborn littermate pigs were fed either colostrum, an elemental diet (ED), or an ED supplemented with purified serum IgG (ED + IgG) for 24 h or then only ED up to 72
BACKGROUND: Ciclosporin is used as an immunosuppressant in current clinical practice but recent research implies novel indications for the drug, such as neuro- and cardioprotection. The intravenous formulation currently on the market, Sandimmune(®) Injection (Sandimmune(®)), uses Cremophor(®) EL as emulsifying excipient. Cremophor(®) EL is known to cause hypersensitivity reactions in some patients
We present results for three charmonia states (psi' chi(c), and J/ psi) in d + Au collisions at vertical bar y vertical bar < 0.35 and root s(NN) = 200 GeV. We find that the modification of the psi' yield relative to that of the J/ psi scales approximately with charged particle multiplicity at midrapidity across p + A, d + Au, and A + A results from the Super Proton Synchrotron and the Relativisti
To highlight methodologic challenges pertinent to design, analysis, and reporting of results of randomized clinical trials in OA and offer practical suggestions to overcome these challenges. The topics covered in this paper include subject selection, randomization, approaches to handling missing data, subgroup analysis, sample size, and issues related to changing design mid-way through the study.
Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-c
The purpose of this study was to determine long-term risk factors for substance-induced and primary psychosis after release from prison.
Disordered eating and its associations with psychological difficulties and body satisfaction were prospectively studied in a community sample of 13-15 year old adolescent girls (N = 428). General psychological difficulties (including hyperactivity-inattention) and lower levels of body satisfaction at T1 were found to predict disordered eating at follow-up one year later (T2). Furthermore, reciproc
A process combining dark fermentation and photofermentation for production of hydrogen is interesting due to its potential of producing hydrogen at a high yields. In this study, the hydrogen process is compared to a 2nd generation ethanol process with respect to cost and with the aim of increasing our understanding of the pros and cons and giving a clear picture of the present status of the two pr
A detailed study has been made of soot growth in two premixed flat ethylene/air flames, at I broken vertical bar = 2.1 and I broken vertical bar = 2.3, where focus has been on following the change in optical properties from nascent to more mature soot, and the importance of these properties for laser-induced incandescence (LII). A combination of two-color LII (2C-LII) and elastic light scattering
Over the last years an expanding family of small RNAs (i.e. microRNAs, siRNAs and piRNAs) was recognized as key players in diverse forms of gene silencing and chromatin organization. Effectors functions of these small RNAs are achieved through ribonucleoprotein (RNP) complexes containing at their center an Argonaute/Piwi protein. Although these proteins and their small RNA-associated machinery can
