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von Willebrand factor (VWF), a multimeric protein with a central role in hemostasis, has been shown to interact with complement components. However, results are contrasting and inconclusive. By studying 20 patients with congenital thrombotic thrombocytopenic purpura (cTTP) who cannot cleave VWF multimers because of genetic ADAMTS13 deficiency, we investigated the mechanism through which VWF modula
In the media and communications field, research investigating the digital media engagements of very young children at home has largely been restricted to survey methods relying on parental self-reports. Recognizing that qualitative approaches can provide insights in families’ practices, values, and attitudes, we argue for the fruitfulness of an ethnographic perspective, drawing on three cases from
Neoliberalisation process was imposed worldwide and it made many grassroots responses emerge, which many can be conceptualised as part of the Social and Solidarity Economy (SSE). Within this field, worker co-operatives appear as an option to mainly safeguard employment and earn a living. Several cases have been documented about worker co-operatives as a way to develop impoverished areas or vulnera
The aim was to describe hematopoietic stem cell (HSC) donors' experiences focusing on information and side effects during the first year after donation. Our prospective Swedish cohort study with adult HSC donors was performed from 2019 to 2022, with questionnaires at four time points from before until 12 months after donation. 173 unrelated and 68 related donors participated, and the majority dona
In the effort to obtain a precise measurement of leptonic CP-violation with the ESSνSB experiment, accurate and fast reconstruction of detector events plays a pivotal role. In this work, we examine the possibility of replacing the currently proposed likelihood-based reconstruction method with an approach based on Graph Neural Networks (GNNs). As the likelihood-based reconstruction method is reason
National hydrogen strategies are emerging as a critical pillar of climate change policy. For homes connected to the gas grid, hydrogen may offer an alternative decarbonisation pathway to electrification. Hydrogen production pathways in countries such as the UK will involve both the gas network and the electricity grid, with related policy choices and investment decisions impacting the potential co
Metal–organic frameworks such as ZIF-8, grown in situ on nanocellulose (NC), have gained significant attention in recent years due to the versatility of the processing route and multifaceted application in the field of environmental remediation and biomedical applications. However, insights into the interactions between NC and MOF precursors and MOF structure evolution during in situ synthesis are
It is a well-established fact that the use of gestures is a ubiquitous feature of communication with language. This is true for both spoken and signed languages. However, while in spoken languages, gestures are produced in a different modality than speech (visual versus vocal/auditory, respectively), gestural elements in sign languages are produced in the same modality as sign (both are visual). T
Population growth and climate change have accelerated groundwater depletion globally. Interferometric synthetic aperture radar (InSAR) is a fairly new satellite remote sensing technique based on SAR images that offers a high-accuracy monitoring system of land surface motion driven by groundwater level changes in time and space that can never be achieved with point-in-situ measurements. In producti
This study examines whether and to what extent the bandwagon effect and the spiral of silence impact opinion formation in a polarized context, where individuals tend to be persistent in their policy attitudes. Focusing on contentious policy issues at the heart of the culture war in American politics, our aim is to study the relative importance of attitude persistence and social conformity in the o
SwedAD, a Swedish nationwide registry for patients with atopic dermatitis receiving systemic pharmacotherapy, was launched on 1 September 2019. We describe here the establishment of a user-friendly registry to the benefit of patients with atopic dermatitis. By 5 November 2022, 38 clinics had recorded 931 treatment episodes in 850 patients with an approximate national coverage rate of 40%. Characte
Neighborhood support can improve aging in place for older adults, but research on the role of public housing staff in supporting older tenants is lacking. Twenty-nine participants (janitors, n = 11; maintenance staff, n = 18) collected data about critical situations among older tenants residing in apartments in Sweden. Modifying the Critical Incident Technique (CIT) and applying a mixed-methods de
A novel macro intermediate based on poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) was synthesized for use in the copolymerization with dimethyl amino ethyl methacrylate (DMAEMA). Methyl amino ethanol was reacted with PHBHHx to prepare a dihydroxy terminated polyester. The hydroxyl ends of the obtained PHBHHx derivatives were capped with 4,4’-azobis cyanopentanoic acid to obtain the PHBHHx
Hodgkin lymphoma (HL) survivors have an increased morbidity and mortality from secondary cancers and cardiovascular disease (CD). We evaluate doses with involved node radiotherapy (INRT) delivered as 3D conformal radiotherapy (3D CRT), volumetric modulated arc therapy (VMAT), or proton therapy (PT), compared with the extensive Mantle Field (MF). Patients and methods: For 27 patients with early-sta
Amplification of the MYCN oncogene is found in ~20% of neuroblastoma (NB) cases and correlates with high-risk disease and poor prognosis. Despite the plethora of studies describing the role of MYCN in NB, the exact molecular mechanisms underlying MYCN’s contribution to high-risk disease are not completely understood. Herein, we implemented an integrative approach combining publicly available RNA-S
The Dynamic Collections project is an ongoing initiative pursued by the Visual Computing Lab ISTI-CNR in Italy and the Lund University Digital Archaeology Laboratory-DARKLab, Sweden. The aim of this project is to explore the possibilities offered by a deep, structured interaction with a large set of digital replicas of archeological artefacts. The project developed and deployed a web-based platfor
This article discusses the relationship between undocumentedness, informality, and vulnerability to crime among migrants, using the strain theory as a conceptual framework. Research on victimisation and engagement in crime among migrants is limited, and existing studies tend to focus on one aspect rather than the interplay between the two. This study focuses on the experiences of the Uzbek communi
In this chapter I analyse the recent criminalization of negligent rape in Sweden, introduced in 2018. My aim is to contribute to the discussion of criminalization as it relates to violence against women, while taking a broad view of criminalization that includes not only criminalization per se but also the application of law. My analysis of the application of the crime of negligent rape, from the
