Filtyp
Moraxella IgD-binding protein (MID) is a well characterized trimeric autotransporter that specifically targets the IgD of B cells. We fused the membrane anchor of the meningococcal autotransporter NhhA with the IgD-binding region of MID (aa 962-1200) to create a chimeric protein designated as NID. The aim was to use this specific targeting to provide a better vaccine candidate against meningococci
A robust and general solver for Laplace’s equation on the interior of a simply connected domain in the plane is described and tested. The solver handles general piecewise smooth domains and Dirichlet, Neumann, and Robin boundary conditions. It is based on an integral equation formulation of the problem. Difficulties due to changes in boundary conditions and corners, cusps, or other examples of non
Adsorption of uncharged homopolymers of various flexibilities in good solvent onto planar surfaces Lit various polymer-surface interaction strengths have been investigated by employing a coarse-grained bead-spring polymer model using simulation techniques. The polymer flexibility ranged from fully flexible to rod-like polymers, and the adsorption strength varied from weak to strong adsorption. Equ
During the last decades regional income divergence seems to have reappeared in both developed and developing countries. In Taiwan – a renowned case of growth with equity – regional per capita income was converging until the early 1990s after which it began to diverge. With the help of modeled annual household survey data from 1976 to 2005 we indicate the magnitude of a regional bonus and discuss r
In lung adenocarcinoma, EGFR and KRAS mutations dominate the mutational spectrum and have clear therapeutic implications. We sought to determine whether transcriptional subgroups of clinical relevance exist within EGFR-mutated, KRAS-mutated, or EGFR and KRAS-wild type (EGFRwt/KRASwt) adenocarcinomas.
The ability of particles to activate and form cloud droplets influences the functioning of the Earth's hydrological cycle. This work links the particle water uptake at subsaturation to the critical supersaturation ratio needed for particles to become cloud condensation nuclei (CCN). Five models using the particle hygroscopic growth at subsaturation for predicting the critical supersaturation neede
We address the dispersion properties of overdamped Brownian particles migrating in a two-dimensional acoustophoretic microchannel, where a pressure-driven axial Stokes flow coexists with a transverse acoustophoretic potential. Depending on the number and symmetries of the stable nodal points of the acoustophoretic force with respect to the axial velocity profile, different convection-enhanced disp
Monolithic macroporous cryogel imprinted with protein G was prepared using a functional co-monomer of N-methacryloyl-l-phenylalanine and 2-hydroxyethyl methacrylate. The chemical structure of the cryogel prepared was studied by FTIR-spectroscopy and its porosity was analysed using scanning electron microscopy. The cryogel was used to purify protein G from recombinant Escherichia coli cell lysate a
Background: There is much interest in how the Amazon rainforest may respond to future rainfall reduction. However, there are relatively few ecosystem-scale studies to inform this debate. Aims: We described the carbon cycle in a 1 ha rainforest plot subjected to 8-10 consecutive years of ca. 50% through-fall reduction (TFR) and compare these results with those from a nearby, unmodified control plot
Inclusive jet and dijet cross sections have been measured in proton-proton collisions at a center-of-mass energy of 7 TeV using the ATLAS detector at the Large Hadron Collider. The cross sections were measured using jets clustered with the anti-kt algorithm with parameters R = 0.4 and R = 0.6. These measurements are based on the 2010 data sample, consisting of a total integrated luminosity of 37 p
Most wastewater treatment plants contain an activated sludge process, which consists of a biological reactor and a sedimentation tank. The purpose is to reduce the incoming organic material and dissolved nutrients (the substrate). This is done in the biological reactor where micro-organisms (the biomass) decompose the substrate. The biomass is then separated from the water in the sedimentation tan
Abstract Objective. Periodontal ligament (PDL) cells produce IL-6 upon stimulation with inflammation promoters, but the signaling pathways involved have not been characterized. This study investigates underlying mechanisms behind regulation of PDL cell IL-6 production by E. coli and P. gingivalis LPS. Materials and methods: Human PDL cells, endothelial cells and monocytes were stimulated with E. c
Accumulating evidence suggests that a compromised intestinal epithelial barrier (IEB) contributes to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD); however, the exact mechanisms remain unclear. Here we reveal that intestinal mucin 1 (MUC1) levels and glycosylation are decreased in both humans and male mice with MASLD. Enterocyte-specific Muc1 knockout aggravat
After the wider deglaciation of Northern Europe, pioneer reindeer populations started to move into southern Scandinavia; however, this process is poorly understood. In this paper we aim to reconstruct dispersal processes of reindeer into southern and western Sweden from the Late Palaeolithic through to the Early Mesolithic, when reindeer disappear from the record. Has presence of reindeer in south
Here we report an investigation of ultrathin tin oxide films on Pt3Sn(111) using low-energy electron microscopy (LEEM), microspot low-energy electron diffraction (μ-LEED), scanning tunneling microscopy (STM), surface X-ray diffraction (SXRD), and high-resolution X-ray photoelectron spectroscopy (XPS). Oxidation at ∼390–410 °C produces triangular, two-dimensional oxide islands that nucleate rapidly
Introduction: Despite therapeutic achievements in haemophilia care, there is still the need to monitor and define personal treatment outcomes and document results to achieve the best possible care. Hence, a need for unbiased, timely and comprehensive real-world information exists to support informed shared decision-making regarding treatment and care. Aim: To describe a medical device for people l
With organic solar cells surpassing 20% efficiency, the focus is shifting toward understanding the more complex mechanisms in ternary blends. This work investigates the distinct working principles of ternary organic solar cells based on a polymer donor (D) and a nonfullerene acceptor (NFA), with a fullerene acceptor (FA) as the third component. A systematic comparison between ternary D:NFA:FA syst
Background The global prevalence of congenital heart disease (CHD) is increasing. Research on patient-reported outcomes (PROs) predominantly originates from high-income countries, resulting in an incomplete understanding of the true global burden of CHD from the patient perspective. Therefore, we described perceived health, psychological distress and quality of life (QoL) in a large sample of adul
We present an updated characterization of the planetary system orbiting the nearby M2 dwarf GJ 3090 (TOI-177; d=22 pc), based on new high-precision radial velocity (RV) observations from NIRPS and HARPS. With an orbital period of 2.85 d, the transiting sub-Neptune GJ 3090 b has a mass we refine to 4.52 ± 0.47 M>, which, combined with our derived radius of 2.18 ± 0.06 R2, yields a density of 2.40-0
