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Context: Megakaryocytes are the "hallmark" of Philadelphia chromosome-negative myeloproliferative neoplasms, such as essential thrombocythemia, polycythemia vera, and primary myelofibrosis; their morphology in correlation with Janus kinase 2 (JAK2 V617F) mutation as well as clinical and laboratory parameters remains unknown.Objective: To assess the morphology of megakaryocytes in bone marrow biops
The electronic structure of eleven crystalline nickel oxides was investigated by band theory - CNDO method. Both the band and local properties of the electronic structure were calculated and were used for the description of chemical bonding in Ni(II) (NiO, Li2NiO2, Na2NiO2, K2NiO2, BaNiO2, La2NiO4), Ni(III) (LiNiO2, NaNiO2, LaNiO3) and Ni(IV) (BaNiO3) compounds.
Mutations in the androgen receptor gene are considered as incompatible with preservation of fertility and have been suggested as a cause of male infertility. Two adult brothers, referred because of gynecomastia and hormonal levels in serum indicating androgen insensitivity (high sex hormone-binding globulin, and LH levels, despite extremely high testosterone concentration), turned out to be relati
Aim: To investigate whether gut maturation could be induced precociously in an athymic T-cell deficient neonatal rat model. Methods: Fourteen day-old athymic (nude) rats (NIH-Foxn 1rnu) were gavaged with either phytohaemagglutinin - a lectin from red kidney beans (PHA); trypsin - a protease (Prot); or water - vehicle (control) as a single dose on one day or once a day for 3-day. The nude rats were
Ionisation with ultrashort pulses in the extreme ultraviolet (XUV) regime can be used to prepare an ion in a superposition of spin-orbit substates. In this work, we study the coherence properties of such a superposition, created by ionising xenon atoms using two phase-locked XUV pulses at different frequencies. In general, if the duration of the driving pulse exceeds the quantum beat period, depha
This work focuses on the oxidation of tungsten in inert gas atmospheres containing oxygen and moisture. It is particularly relevant for the European Spallation Source where the tungsten target is cooled by purified helium gas and the 5 MW proton beam can raise the maximum target temperature beyond the threshold for oxidation. Tungsten discs were oxidized isothermally at 400° to 900 °C for 2 h in p
Food law, and food labelling, establishes the rights of consumers to safe food and to accurate and honest information. Although food safety is at the core of food information, the broad principle of the food law is about telling the truth about products so that the consumer can make a choice about what they choose to eat. However, food law and labelling can also become a trade barrier and thus con
Purpose – The purpose of this paper is to describe five salient factors that emerge in two successful change processes in healthcare. Organizational changes in healthcare are often characterized by problems and solutions that have been formulated by higher levels of management. This top-down management approach has not been well received by the professional community. As a result, improvement proc
Data representation migration is a program transformation that involves changing the type of a particular data structure, and then updating all of the operations that somehow depend on that data structure according to the new type. Changing the data representation can provide benefits such as improving efficiency and improving the quality of the computed results. Performing such a transf
We analyze the cross-sectional relation between expected idiosyncratic volatility and stock returns. The expected idiosyncratic volatility is conditioned on macro-finance factors as well as traditional asset pricing factors. The macro-finance factors are constructed from a large set of macroeconomic and financial variables. Our results show that the negative relation between expected idiosyncratic
Background: Steroid nasal irrigation for chronic rhinosinusitis patients following endoscopic sinus surgery reduces symptom recurrence. There are minimal safety data to recommend this treatment. This study evaluated the safety of betamethasone nasal irrigation by measuring its impact on endogenous cortisol levels. Methods: Participants performed daily betamethasone nasal irrigation for six weeks.
Iron deficiency without anemia and iron deficiency anemia are common and frequently overlooked complications of inflammatory bowel disease. Despite the frequency and impact of iron deficiency in inflammatory bowel disease, there are gaps in our understanding about its incidence, prevalence and natural history and, consequently, patients may be undertreated. Medical registries have a key role in co
This paper explores the long-term effects of being born with the assistance of a qualified midwife on health and skills, using longitudinal register-based data for individuals born in rural Swedish parishes between 1881 and 1930 and followed from birth until age 80. In the setting of home deliveries, midwives strictly followed hygiene instructions and monitored the health of the mothers and newbor
Type 1 diabetes mellitus (T1D) is a metabolic disease causing hyperglycemia due to β-cell destruction. Despite adequate treatment, complications such as diabetic retinopathy (DR) are common. The first aim was to investigate if acute onset of type 1 diabetes differed between those who had developed retinopathy and who had not after 15 years from diagnosis. The second aim was to investigate if mean
Purpose: To mitigate negative human-induced impact on the planet, consumption patterns need to be changed urgently. The purpose of this paper is to investigate how companies can drive sustainable consumption patterns. Design/methodology/approach: The paper discusses six illustrative cases of sustainable consumption initiatives by companies: their strategies, initiatives and impacts. Findings: A “b
A long run of PVCs “sandwiched” in between the sinus beats resulting in an almost doubling of the heart rate—interpolated PVCs in bigeminy—is described. This case illustrates three interesting aspects of interpolated PVCs. Although they are not uncommon, long runs of interpolated PVCs in bigeminy are rare findings. In this case, the arrhythmia had a duration of 3 minutes. Second, it illustrates th
Current evidence on congenital malformations in the offspring of cancer survivors is largely inconsistent. Therefore, through this study we aimed to explore the prevalence of congenital malformations in the offspring of cancer survivors. To this end, female cancer survivors were identified from the Swedish Cancer Register and were further linked to the Swedish Medical Birth Register and Hospital D
Context Emerging evidence has related the gut microbiome and circulating metabolites to human obesity. Gut microbiota is responsible for several metabolic functions, and altered plasma metabolome might reflect differences in the gut microbiome. Objective To identify a plasma metabolite profile associated with body mass index (BMI) in a general population and investigate whether such metabolite pro
We estimate behavioral spillovers from environmental policy within the context of a natural experiment on food waste in Sweden. Exploiting the staggered implementation of food-waste collection across Swedish municipalities, we use a difference-in-difference design to measure the causal effect of introducing such collection on another pro-environmental behavior, namely the sorting of packaging wast
Gastroesophageal reflux disease (GERD) has a prevalence of 20% based on weekly symptoms of heartburn and regurgitation. As reflux symptoms are unspecific for GERD, an objective evaluation of the presence of the disease is often needed. Ambulatory pH monitoring is the most commonly used diagnostic method but it is limited by relatively poor sensitivity, especially in patients without esophagitis. T
