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Post-zygotic variation refers to genetic changes that arise in the soma of an individual and that are not usually inherited by the next generation. Although there is a paucity of research on such variation, emerging studies show that it is common: individuals are complex mosaics of genetically distinct cells, to such an extent that no two somatic cells are likely to have the exact same genome. Alt
We discovered structurally novel human calcium-sensing receptor (CaSR) allosteric agonists and compared their pharmacology to phenylalkylamine calcimimetics. 1-Benzothiazol-2-yl-1-(2,4-dimethyl-phenyl)-ethanol (AC-265347) activated CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays with potencies of 30 and 10 nM, respectively. (S)-1-Benzothiazol-2-yl-1-(2,4-di
Lignin nanoparticles (nanolignin, NL) were prepared in this work by ultrasonic treatment of softwood kraft lignin to obtain lignin‐water dispersions with excellent colloidal stability. A thorough characterization of the chemical, physical, and morphological properties of the new NL particles allowed for direct comparisons with the untreated parent material. Such NL particles were incorporated into
The use of social media technologies in organizations has introduced novel ways of collaboration, communication, and knowledge sharing. In this respect, the present study is concerned with examining the use of one type of social media, the wiki technology, by members of several professional communities of practice to collaborate and share knowledge with each other. As such, it seeks to identify an
Purpose: The objective of this work is to integrate structural optimization and reliability concepts into mini-plate fixation strategy used in symphysis mandibular fractures. The structural reliability levels are next estimated when considering a single failure mode and multiple failure modes. Patients and Methods: A 3-dimensional finite element model is developed in order to evaluate the ability
BackgroundLittle is known about health and wellbeing among patients with nephrotic syndrome (NS), despite it being a serious condition in patients with renal failure. In order to promote health, it is important that both healthcare professionals and patients are aware of the signs and symptoms of the disease.ObjectivesThe aim was to explore patients’ experience of suffering from nephrotic syndrome
High-pressure homogenizers are often used in tomato juice production to fragment tomato cells, to increase viscosity. Compared to emulsification, little is known about the mechanism of cell breakup in general and of vegetable cell breakup in particular. The objective of this contribution is to extend the mechanistic understanding of vegetable cell breakup in homogenizers, using a research methodol
Population ageing is making it increasingly diffcult for countries to sustain their current levels social welfare transfers from the economically active population to the dependent elderly. To meet this challenge, the Swedish government has implemented various reforms since the 1990s aimed at reducing incentives to take early retirement. However, a critical question has emerged in response to thes
Whether optoelectronic devices based on metal-halide perovskite semiconductors will become a commercially viable technology will be determined by their intrinsic and operational stability. Recent results indicate there is some reversibility of perovskite degradation in thin films and devices, although mechanistic insight into the processes driving degradation and recovery are still scarce. We here
This paper attempts to analyze the concept of localization and its relationship with the psychological performance of zakat. It argued that localization could produce development opportunities from the management decentralization of supply chain in zakat institution. In this study, localization is treated as the mediator, while property rights of zakat and asset specificity performed as the indepe
Sociodemographic factors and lifestyle habits affect body weight and body composition. A new syndrome, called normal-weight obesity (NWO), is found in individuals with normal weight and excess body fat in contrast to lean and overweight individuals. The aim of the present study was to explore the associations between sociodemographic factors and smoking and alcohol habits and lower versus higher B
The Green Revolution in Asia from the early 1960s is defined as a process driven by governments in pursuit of self-sufficiency in food grains. The process was market-mediated and smallholder based and can be dated to the early 1960s with the Nobel Prize Laureate, Norman Borlaug’s research on high-yielding dwarf wheat in Mexico and later spread to rice and number of countries in South East and Sout
