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Objective. To evaluate outcome after radical cystectomy for primary bladder cancer in a large population-based material. Material and methods. Between 1997 and 2002 all patients treated with radical cystectomy within 3 months after diagnosis of primary bladder cancer without distant metastasis were retrieved through the Swedish Bladder Cancer Registry. A follow-up questionnaire was distributed to
Stories about another country are often viewed as filled with stereotypes and prejudices. Still there are other ways to organize foreign experiences, especially for actors needing to achieve an attitude of proximity. This article analyzes arrival stories, in this case Swedish businessmen’s stories about their first arrival to a post-communist country, in order to show how such stories may be used
Tasquinimod (a quinoline-3-carboxyamide) is a small molecule immunotherapy with demonstrated effects on the tumor microenvironment (TME) involving immunomodulation, anti-angiogenesis and inhibition of metastasis. A target molecule of tasquinimod is the inflammatory protein S100A9 which has been shown to affect the accumulation and function of suppressive myeloid cell subsets in tumors. Given the m
Background: Although diet has long been suspected as an etiological factor for colorectal cancer, studies of single foods and nutrients have provided inconsistent results. Objective: We used factor analysis methods to study associations between dietary patterns and colorectal cancer in middle-aged Americans. Design: Diet was assessed among 293 615 men and 198 767 women in the National Institutes o
Aims: The aim was to establish a baseline prevalence of skin conditions of public health importance in the general population and taking the validity of the questions into account. Our model is intended for future surveillance of skin conditions. Methods: The suggested questions have for the first time been used in Swedish population surveys. A random sample was taken from the general population a
This paper analyses biofuels from agricultural crops in northern Europe regarding area and energy efficiency, greenhouse gases and eutrophication. The overall findings are that direct land use changes have a significant impact on GHG balances and eutrophication for all biofuels, the choice of calculation methods when by-products are included affecting the performance of food crop-based biofuels co
Endotoxin exposure associated with organic dust exposure has been studied in several industries. Coffee cherries that are dried directly after harvest may differ in dust and endotoxin emissions to those that are peeled and washed before drying. The aim of this study was to measure personal total dust and endotoxin levels and to evaluate their determinants of exposure in coffee processing factories
The purpose of this thesis was to determine whether perimetry using a new model to interpret deterioration or improvement in the visual field can be employed to assess change in visual function over time in diabetes. Diabetic retinopathy has long been considered a microvascular disease, but it is still a matter of debate to what extent diabetes also affects retinal neurons. Visual acuity is routi
Systemic instigation is a process by which endocrine signals sent from certain tumors (instigators) stimulate BM cells (BMCs), which are mobilized into the circulation and subsequently foster the growth of otherwise indolent carcinoma cells (responders) residing at distant anatomical sites. The identity of the BMCs and their specific contribution or contributions to responder tumor growth have bee
The globular protein γB-crystallin exhibits a complex phase behavior, where liquid-liquid phase separation characterized by a critical volume fraction ϕc = 0.154 and a critical temperature Tc = 291.8 K coexists with dynamical arrest on all length scales at volume fractions around ϕ ≈ 0.3-0.35, and an arrest line that extends well into the unstable region below the spinodal. However, although the s
All is a 17-kDa chromosomally encoded outer membrane protein that mediates serum resistance (complement resistance) in the pathogenic Yersiniae (Yersinia pestis, Y. enterocolitica, and Y. pseudotuberculosis). In this article, we demonstrate that Y pseudotuberculosis Ail from strains PB1, 2812/79, and YPIII/pIB1 (serotypes O:1a, O:1b, and O:3, respectively) can bind the inhibitor of the classical a
In this paper, we study machine learning techniques and features of electroencephalography activity bursts for predicting outcome in extremely preterm infants. It was previously shown that the distribution of interburst interval durations predicts clinical outcome, but in previous work the information within the bursts has been neglected. In this paper, we perform exploratory analysis of feature e
Objective. Large-bore catheters for temporary haemodialysis are often placed via the internal jugular or femoral vein, guided by external landmarks or ultrasound techniques. Inadvertent femoral artery catheterization may occur during attempted placement of the dialysis catheter in the femoral vein. Material and methods. This investigation was carried out in Skane University Hospital, Malmo, Sweden
Umbilical cord blood acid-base status at birth gives an objective evaluation of the fetal exposure and response to hypoxia during labor. The objective of this thesis was to elucidate methodological issues associated with interpretation of cord blood gases. DELAYED CORD BLOOD SAMPLING (Paper I): arterial and venous pH and bicarbonate decreased, and pCO2, base deficit (BD), and lactate increased sig
Lund University Cardiopulmonary Assist System (LUCAS) is a mechanical device providing automatic 5 cm deep chest compressions and active decompressions back to normal anatomical position with a frequency of 100 per minute, and a duty cycle of 50%, i.e., LUCAS is constructed to give chest compressions according to the latest international guidelines in cardiopulmonary resuscitation (CPR). The aim
Genetic alterations underlying the development of the cancer of the nose and paranasal sinuses (sinonasal cancer, SNC), a rare cancer that can be included in the group of head and neck cancers, are still largely unknown. We recently reported that TP53 mutations are a common feature of SNC, with an overall frequency of 77%, and they show association to adenocarcinoma and wood-dust exposure [15]. In
Low-intensity laser prepulses (<10(13) W cm(-2), nanosecond duration) are a major issue in experiments on laser-induced generation of protons, often limiting the performances of proton sources produced by high-intensity lasers (approximate to 10(19) W cm(-2), picosecond or femtosecond duration). Depending on the intensity regime, several effects may be associated with the prepulse, some of which a
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Målet med denna avhandling var att undersöka hur cancersjukdomar i barndomen och behandlingen av dessa påverkar olika aspekter av fortplantningsförmågan i vuxen ålder. Glädjande nog har andelen patienter som överlever cancer i barndomen de senaste decennierna ökat stadigt till nivåer som idag ligger på nästan 80%. Ökad överlevnad medfChildhood cancer (CC) survival rate has increased over the last couple of decades, today approaching 80%. Therefore more attention has been paid to late effects. One important issue for CC survivors (CCS) is impaired reproductive function. CC per se and/or its treatment can impair the reproductive ability by affecting sperm production, as well as by damaging sperm DNA. This is a matter of concern,
Popular Abstract in Swedish Arbetsförmåga har kommit att bli ett viktigt begrepp i samhället, men också för individen. Det saknas i dag en tydlig definition av arbetsförmåga, trots att det har en stor inverkan på hur sjukförmåner distribueras och också för den enskilde individens möjlighet att försörja sig. I västvärlden är arbetsförmåga ofta diskuterat i relation till sjukskrivning och en åldrad The overall aim of this thesis was to deepen the understanding of work ability by analyzing how different health professionals experience and perceive work ability and assessments of work ability, and also by analyzing rehabilitation outcomes that are related to work ability. The focus has been on musculoskeletal disorders with associated psychosocial factors. Method. The general approach was indu
Preservatives are biologically active substances mainly used in water-based products to prevent the growth of microorganisms. Most people are exposed to them on a daily basis. Formaldehyde is one of the oldest and most commonly used preservatives. However, it is a well-known contact sensitiser in dermatitis patients. The aims of this work were: i) to investigate the prevalence of contact allergy t
