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The increasing implementation of next-generation sequencing technologies in the clinical context and the expanding commercial offer of genetic tests directly-toconsumers has increased the availability of previously inaccessible genetic information. A particular concern in both situations is how the volume of novel information will affect the processing of genetic and genomic information from minor
"Abstract in Italian": La post-verità dei discorsi politici, esemplificata nella retorica di Trump, non si basa principalmente sui fatti. Ciò che sembra essere importante, quando l’elettorato valuta questi discorsi, è se i politici che parlano sono veritieri o autentici, non se ogni parola pronunciata è ‘vera’. Pertanto, le valutazioni critiche dei discorsi politici populisti dovrebbero iniziare pPost-truth political discourses, exemplified by Trump’s rhetoric, are not primarily based on facts. What appears to be important when the electorate evaluates these discourses is whether the politicians who are speaking are genuine or authentic, not whether every word uttered is ‘true’. Therefore, critical evaluations of populist political discourses should begin by asking questions about what kin
Background: Patent false lumen has been shown to have a negative impact on prognosis after surgery for acute type A aortic dissection (ATAAD). We aimed to assess the effect of postoperative anticoagulation on false lumen patency and clinical outcomes in relation to false lumen status. Methods: Postoperative computed tomographies of 156 patients undergoing ATAAD DeBakey type I surgery were retrospe
Research has demonstrated an unwillingness among travelers to reduce their holiday flying. Recently, however, a movement with people avoiding and problematizing flying has emerged in Sweden and spread internationally. This paper explores how the rising problematization of flying changes the meanings of holiday air travel in a carbon-constrained world. Using travel magazines and digital media sourc
Alzheimer´s disease (AD) is the most common human neuro-degenerative disease characterized by the formation of cerebral plaques. Several are the amyloid-beta (Aβ) variants found in the brain of healthy individuals. Among them, the Aβ40 variant is predominantly found in the cerebrospinal fluid while the Aβ42 variant appears as fibrillar aggregates in the brain of AD patients. In vitro studies confi
Background: Breast-reduction techniques are increasingly used in oncoplastic breast surgery. Bilateral therapeutic mammoplasty has the benefit of decreasing breast volume, enabling resection of larger tumors, and the potential to assure good postoperative symmetry. The aims of this study were to objectively asses the cosmetic outcomes of therapeutic mammoplasty in patients with breast cancer, usin
SNOW 3G is a stream cipher used as one of the standard algorithms for data confidentiality and integrity protection over the air interface in the 3G and 4G mobile communication systems. SNOW-V is a recent new version that was proposed as a candidate for inclusion in the 5G standard. In this paper, we propose a faster variant of SNOW-V, called SNOW-Vi, that can reach the targeted speeds for 5G in a
Background: Lead-time is defined as the time by which screening advances the diagnosis compared with absence of screening. A sufficiently long lead-time needs to be achieved so that cancer can be detected while still curable. A very short lead-time may indicate poor sensitivity of the screening test, while a very long lead-time suggests overdiagnosis. Material and methods: In the first screening r
This paper presents an innovative study of the port system of Rome in Imperial times through the application of an integrated approach to both archaeological analysis and material evidence. Specifically, it seeks to provide a more complete contextualization and understanding of the port system of Rome by focusing on the exploration of the physical geography of the river Tiber and its transformatio
Polyphenolic compounds in bark are resources of great interest to produce renewable chemicals and several different technologies are available or under early development for the extraction of these types of compounds. Since critical environmental effects of a product are often set during the design phase, it is important to use life cycle assessment (LCA) to identify the steps resulting in the lar
Background: Evidence is increasing for the use of faecal immunochemical tests (FITs) for occult blood as diagnostic tools when colorectal cancer can be suspected. FITs have been used for this purpose in Swedish primary care since around 2005 despite absence of supporting guidelines. To our knowledge, the extent of this use has not been studied. Objective: To investigate the use of FITs as diagnost
Background: The free PSA fraction in serum of patients with various prostatic disorders is essentially unreactive with the anti-proteases in blood. Recently reported data show that it is likely to consist of a mixture of proPSA, internally cleaved PSA forms, and possibly other uncharacterized forms. Currently there are no specific methods available to measure the different free PSA subfractions an
Introduction: Cervical cancer is a major cause of mortality and morbidity. We aimed to estimate the association between sociodemographic factors and cervical neoplasia. Material and methods: In this Swedish nationwide open cohort study, 4 120 557 women aged ≥15 years at baseline were included between January 1, 2002 and December 31, 2018. The two outcomes were cervical cancer and carcinoma in situ
CONTEXT: Vitamin D (Vit-D), parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23) are the major calciotropic hormones involved in the regulation of blood calcium levels from the intestine, kidney, and bone through a tight endocrine feedback loop system. Altered levels of calcium itself or through the effect of its regulatory hormones could affect blood pressure (BP), but the exact mec
Background: Proton beam therapy penetrates tumor tissues with a highly concentrated dose. It is useful when normal structures are too proximate to the treatment target and, thus, may be damaged by surgery or conventional photon beam therapy. However, proton beam therapy has only been used to treat recurrent endometrial cancer in a few cases; therefore, its effectiveness remains unclear. Case prese
The Paris Agreement suggests that all countries engage in significant emission reductions. To stay within safe guardrails, usually defined as a maximum warming of 1.5 °C compared to pre-industrial times, this will mean decarbonisation within less than 30 years. This significant challenge is complicated because of growth in some sectors, such as tourism. This paper analyses emissions and economic o
