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The success of cancer immunotherapy depends on the priming of tumor-specific T and B lymphocytes. However, tumor cells often downregulate antigen presentation and mount an immunosuppressive tumor microenvironment (TME), which excludes immunogenic cells and hinders broad success of cancer immunotherapies, including immune checkpoint blockade (ICB). Type 1 conventional dendritic cells (cDC1s) are cr
Background: Depression and suicidal behavior have been linked to increased blood-brain barrier (BBB) permeability. Platelet-derived growth factor receptor beta (PDGFR-β) is widely expressed in pericytes and promotes BBB integrity. Here, we investigated cerebrospinal fluid (CSF) levels of PDGFR-β in suicide attempters and healthy controls and correlated PDGFR-β to depression symptom severity. Metho
BACKGROUND: A history of hypertensive disorders of pregnancy is associated with at least twice the risk of incident ischemic heart disease. Whether the long-term outcome following treatment with coronary artery stenting is associated to the history of hypertensive disorders of pregnancy is unknown. METHODS AND RESULTS: We included 8364 women (age ≤65 years) undergoing first coronary artery stentin
A study of strange hadron production associated with hard scattering processes and with the underlying event is conducted to investigate the origin of the enhanced production of strange hadrons in small collision systems characterised by large charged-particle multiplicities. For this purpose, the production of the single-strange meson KS0 and the double-strange baryon Ξ± is measured, in each even
Purpose: To introduce a newly developed digital platform and compare its reliability and agreement with paper-based questionnaires for assessing quality of vision before and after cataract surgery. Setting: University-affiliated ophthalmology department and private clinic. Design: Prospective, randomized trial with parallel design of 1:1 allocation ratio without masking. Methods: Between 11/2021 a
The work seeks to assess the effect of technological innovation on the green growth of tourism across five continental regions using the STochastic estimation of Impacts by Regression on Population, Affluence, and Technology (STIRPAT) model. Employing panel Granger causality tests, panel vector autoregression, impulse response functions, and forecast error variance decomposition, the research reve
Using population reconstructions from linked civil certificates for the province of Zeeland, the Netherlands, for the period 1812–1913, I study the social gradient in maternal mortality. Maternal mortality is defined as deaths in the first 42 days after the birth of a child. Among the women — mother to at least one child and followed between age 20 and 45 — maternal mortality constitutes about one
The diagnostic potential of femtosecond (fs) rotational coherent Raman scattering (RCRS) in the time domain is initially investigated. While RCRS concepts in the spectral domain obtain species selectivity and temperature sensitivity by resolving the spectral shape, mainly reflecting the Boltzmann-distributed, rotational populations of the Raman-active molecules present, the current time-domain fs-
Pregnant women have historically and are currently being excluded from cervical cancer screening in most low and middle-income countries (LMICs). The aim of this study was to assess the feasibility and outcomes of including pregnant women in a HPV self-sampling-based screening program in Ethiopia. Pregnant women, recruited from a previously established cohort, were included. They answered a questi
In this chapter, we explore mathematical tools for assessing the stability, convergence, and boundedness of trajectories in generally nonlinear dynamical systems. We delve into the seminal theorems introduced by A. Lyapunov which are primarily concerned with the stability of equilibrium points. The chapter progresses to discuss the extension of Lyapunov's Theory, due to LaSalle, aimed at assessing
An abnormal blood pressure (BP) response on standing is associated with atherosclerotic cardiovascular disease (CVD). The role of physical activity (PA) on orthostatic BP-reactions and its relation to subclinical atherosclerosis is unclear. We aimed to assess the association between PA and orthostatic BP-reactions, and whether PA modifies the relationship between orthostatic BP-reactions and subcl
This study is about the vulnerability of parents to adult children with drug problems. The study is based on a self-reporting questionnaire (n = 687) distributed to parents in Sweden via family member organizations, treatment centers, and online communities. Most parents reported extensive negative consequences on relationships, social life, and mental health due to their children’s drug problems.
Hydrogen-fuelled technologies for home heating and cooking may provide a low-carbon solution for decarbonising parts of the global housing stock. For the transition to transpire, the attitudes and perceptions of consumers must be factored into policy making efforts. However, empirical studies are yet to explore potential levels of consumer heterogeneity regarding domestic hydrogen acceptance. In r
This study explores how listeners use verb constructions to describe everyday sounds. It considers (i) how the verb constructions provide Gestalt to events in the form of activities, processes and states, and (ii) how the constructions correspond to different aspects of a soundscape (sound sources, acoustic properties, and listener reactions). We found that verb constructions primarily describe so
Aims: Social science literature suggests that unlimited trust in others may lead to adverse outcomes, and that moderate trust may be more optimal in social interactions. The aim was to analyze associations between generalized trust in other people and all-cause mortality using a four-alternative generalized trust item that includes moderate trust. Study design: Prospective cohort study. Methods: T
This study featured about the synthesis of graphene oxide hydrogel-CuO@reduced graphene oxide (rGH-CuO@rGO) micromotors with core-shell structure via an ultrasonication-assisted chemical precipitation method and their application for catalytic dye degradation. The micromotors were comprehensively characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron mi
Radiographic axial spondyloarthritis (r-axSpA) is associated with increased cardiovascular disease (CVD) risk. The coronary artery calcification (CAC) score, an atherosclerosis burden indicator that predicts CVD risk, is not well studied in r-axSpA. This study investigates CAC scores in patients with r-axSpA compared to controls without rheumatic disease and factors associated with CAC scores in r
PMSMs have acquired wide applications in industries because of high power density, high efficiency, and reliable operation. PMSMs possess numerous benefits, including low maintenance, smooth operation, quick dynamic response, and improved thermal management due to permanent magnets used instead of rotor windings. These characteristics render PMSMs suitable for use in electric vehicles (EVs), indus
Article 12 of the UN Convention on the Rights of Persons with Disabilities requires states parties to take appropriate measures to ensure that persons with disabilities have access to the support they may need in exercising their legal capacity. However, this obligation remains ambiguous. What exactly is decision-making support meant to accomplish? Until this fundamental issue has been clarified,
Objectives: Breast-fed (BF) have lower risk of infections during infancy compared to those formula-fed (FF). A higher content of alpha-lactalbumin (α-lac) in breast milk, which may promote a more favorable gut microbiota, could be one reason. In this study, we evaluated whether increased concentration of α-lac in low-protein infant formula affects the immune response and the incidence of infection
