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PurposeLonger and heavier road freight vehicles, so called High Capacity Vehicles (HCVs) are likely to be implemented by the Swedish government in the near future. This paper analyses the effects on tonne-kilometres, vehicle-kilometres, CO2 and socio-economics of three possible implementation strategies (HCVs on all roads, a designated road network, a designated road network with km-based truck ch
As radiotherapy using ultra-high dose rates has gained new interest, the dosimetric challenges arising at these conditions needs to be addressed. Ionization chambers suffer from a large decrease in ion collection efficiency due to ion recombination, making on-line dosimetry difficult. In this work we present experimental setups and dosimetric procedures for FLASH irradiation of cells, zebrafish em
Introduction: Allergen exposure worsens viral-triggered asthma exacerbations and could predispose the host to secondary bacterial infections. We have previously demonstrated that exposure to house dust mite (HDM) reduced TLR-3-induced IFN-β in human bronchial epithelial cells (HBECs) from healthy donors. We hypothesize that HDM sensitization in different ways may be involved in both viral and bact
The urban form and extreme microclimate events can have an important impact on the energy performance of buildings, urban comfort and human health. State-of-the-art building energy simulations require information on the urban microclimate, but typically rely on ad-hoc numerical simulations, expensive in-situ measurements, or data from nearby weather stations. As such, they do not account for the f
In order to simplify the hyperelastic characterisation of rubber materials, an extension of the standard hardness test is proposed. A number of indentation depths are chosen for the hardness test and the indentation forces for these depths are recorded. By this modification, hyperelastic constants can be derived from the test, providing more information from the test by a small extra effort. Equiv
Background: Digitally mediated primary healthcare is increasingly influencing working conditions, raising questions about how digitally mediated patient management is experienced. Aim: The aim of this study was to generate insights, through the lens of postphenomenology, into how digitally mediated primary healthcare affects the work and working environment, by gathering perspectives from primary
Many aspects of the process of in vitro differentiation of chondrocytes in three-dimensional (3D) scaffolds need to be further investigated. Chitosan scaffolds were produced by freeze-drying 3% w/v 90% DDA chitosan gels. The effect of the cell seeding concentration was evaluated by culturing human adult chondrocytes in chitosan scaffolds After the first passage, cells were seeded into chitosan sca
Patients with rheumatoid arthritis (RA) have an increased risk of infections; therefore, immunization against vaccine-preventable diseases is important. Methotrexate (MTX) impairs the antibody response to pneumococcal conjugate vaccine (PCV) in patients with arthritis, and the underlying mechanism is largely unknown. Here, we investigate the potential role of the innate immune system in the falter
This thesis is focused on cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D), two concomitant conditions that appear with growing concern. In our work, we aim to improve the identification of individuals at-risk of cardiometabolic disease through the characterization of complex environmental exposures (i.e. diet, physical activity), that temporally vary, and the health effects on card
BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is a common cardiovascular autonomic disorder characterized by excessive heart rate (HR) increase on standing and symptoms of orthostatic intolerance, posing significant limitations on functional capacity. No objective tool exists to classify symptom burden in POTS.METHODS: We conducted a case-control study in 62 POTS patients and 50 hea
Parkinson's disease (PD) is a complex neurodegenerative condition in which genetic and environmental factors interact to contribute to its etiology. Remarkable progress has been made in deciphering disease etiology through genetic approaches, but there is limited data about how environmental and genetic factors interact to modify penetrance, risk, and disease severity. Here, we provide insights in
Due to the growing awareness that insects' diversity and populations are in decline, there is an increased need for monitoring insects. Entomological lidars and photonic sensors can monitor and remotely identify flying insects based on their backscattered signal in terms of oscillations-, polarization-, and spectral content. The backscattered light from insects is predominantly oscillatory and der
Purpose: India has acquired global leadership in renewable energy (RE) deployment because of its commitment to achieve 175 GW of installed capacity by 2022. Entrepreneurship driven by innovation and policy push is essential for energy sector transition. Despite policy focus on the diffusion of RE technology, there are several challenges that plague innovation and RE entrepreneurship development in
Computer vision/deep learning-based 3D human pose estimation methods aim to localize human joints from images and videos. Pose representation is normally limited to 3D joint positional/translational degrees of freedom (3DOFs), however, a further three rotational DOFs (6DOFs) are required for many potential biomechanical applications. Positional DOFs are insufficient to analytically solve for joint
Aviation remains a problematic sector of the global economy in times of climate emergency. Grounded in the ideology of reconfiguration, we adopt a system transitions perspective to address high emissions leisure travel. Our focus falls on the marketing communications of airlines as a critical component in the prevailing sociotechnical regime. Thematic analysis of the e-mail marketing communication
Sherlock Holmes has travelled across media borders extensively: from technical to technical medium, from basic to basic medium, and from qualified to qualified medium. Through the decades, Sherlock Holmes appeared in many different forms of storytelling and media constellations, so we can analyse the character in terms of transmediality. This chapter discusses one such example: Penny Dreadful, whi
Different forms of major histocompatibility complex (MHC) class I heavy chains are known to be expressed on the cell surface, including molecules which are functionally 'empty'. Direct peptide binding to cells is obvious during sensitization of target cells in vitro for cytotoxic T lymphocyte killing and 'empty' MHC-I molecules are comparatively abundant on TAP- 1 2 peptide transporter mutant cell
High energy collisions at the High-Luminosity Large Hadron Collider (LHC) produce a large number of particles along the beam collision axis, outside of the acceptance of existing LHC experiments. The proposed Forward Physics Facility (FPF), to be located several hundred meters from the ATLAS interaction point and shielded by concrete and rock, will host a suite of experiments to probe standard mod
