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Introduction: Twelve-lead electrocardiogram (ECG) is used to screen for hypertrophic cardiomyopathy (HCM), but up to 25% of HCM patients do not have distinctly abnormal ECGs, whereas up to 5% to 15% of healthy athletes do. We hypothesized that an approximately 5-minute resting advanced 12-lead ECG test ("A-ECG score") could detect HCM with greater sensitivity than pooled conventional ECG criteria
Ischemia-reperfusion injury in transplantation remains a significant clinical challenge with regard to both short-term and long-term complications. In this study, we developed a new amphiphilic construct, polyethylene glycol (PEG)-conjugated lipids (PEG-LIPIDs), to be administered ex vivo intra-arterially to procured porcine kidney allografts before reperfusion. The aim was to create a protective
This paper presents the WUISHOW, a digital collaborative evacuation decision-making tool designed to assist wildland-urban interface (WUI) fire stakeholders in emergency management and response. The tool has been developed with a dual scope: 1) to allow assessment of end users needs and 2) to allow visualisation through procedural generation of the results of wildfire evacuation simulations. The W
Myeloid cells, such as monocytes, are central in the immune response to infections. However, limited knowledge exists regarding the inflammatory response to Gram-positive anaerobic cocci (GPAC). To explore the ability of GPACs to induce monocyte activation, we compared two GPAC species, Parvimonas micra and Peptoniphilus harei, with E. coli, a major cause of bloodstream infections. We stimulated w
The purpose of cancer screening is to reduce mortality, and ideally incidence, from the cancer screened for. Until recently, cancer screening has been offered to all persons in pre-defined sex- and age-groups. The exception is lung screening which is targeted to high-risk individuals. Evidence for effect of screening on cancer-specific mortality is available for cancer of the cervix, breast, color
Background: Previously untreated patients with severe hemophilia A exposed to factor (F)VIII are at risk of developing high-titer inhibitors. Traditionally, such children were tried on immune tolerance induction (ITI). With availability of nonfactor therapies, recommendations regarding whether to continue trying ITI and how are lacking. Objectives: To provide data to address these questions, we re
Background: In Sweden 70,000 people suffer fragility fractures annually, including 16,000 hip fractures with one-year mortality of up to 25%. Strategies to prevent falls, improve physical function, and enhance bone strength have shown mixed results. Aim: To evaluate the incidence of hip and other fragility fractures following a fracture prevention intervention and assess baseline risk factors for
Background General adiposity, assessed by body mass index (BMI), is a well-established cancer risk factor. This study compared waist circumference (WC), a measure of abdominal adiposity, with BMI as a risk factor for obesity-related cancers, and assessed whether WC provides additional information beyond BMI. Methods We analyzed data from 339 190 individuals in a pooled Swedish cohort with baseline
Aim: During the COVID-19 pandemic, Sweden chose a more open public health approach. A general concern was that this approach would affect the population negatively. We describe the Swedish national MIS-C cohort and risk factors for severe disease defined as admission to the intensive care unit and cardiogenic shock. Methods: Nationwide population-based cross-sectional study. All children and adole
Objective: This study aimed to describe the regional, population-based, organised prostate cancer testing (OPT) programmes that are being introduced throughout Sweden: motives, structure, target population, diagnostic algorithm, quality control, outcomes, research, and future perspectives. Results: In 2018, the Swedish National Board of Health and Welfare renewed their recommendation against scree
In this paper we revisit positioning from Doppler measurements, using techniques from algebraic geometry to produce new theoretical insights and efficient localization algorithms. First, we give a full characterization of the problem, identifying for each problem their minimal configurations, that is the minimum number of receivers and transmitters to have a finite number of solutions. We also stu
Hydrodeoxygenation (HDO) is a catalytic process applied for the reduction of oxygen levels in hydrocarbons from bio-derived feedstock as part of the processing into renewable fuel. The MoS2-based hydrotreating catalysts, currently being applied for the HDO reaction, are exposed to a complex environment consisting of O-rich hydrocarbons and water, which adversely impacts the state and stability of
Gaining insight into structural and compositional transformations occurring at the electrode/electrolyte interface during the operation of electrochemical systems is fundamental to understanding and, thus, optimizing their performance. Such an analysis must be performed in operando conditions, owing to the potential, electrolyte and time dependence of these transformations. Here, the use of X-ray
We report resonant inelastic x-ray scattering (RIXS) spectra of neon atoms interacting with intense x-ray pulses generated using an x-ray free-electron laser (XFEL). We find that an unexpected peak emerges near the Ka line of Ne, which does not coincide with any physical resonances of neon ions. We perform theoretical calculations based on a quantum-state-resolved rate-equation approach with x-ray
FLASHForward is an experimental facility at DESY dedicated to beam-driven plasma-accelerator research. The X-2 experiment aims to demonstrate acceleration with simultaneous beam-quality preservation and high energy efficiency in a compact plasma stage. We report on the completed commissioning, first experimental results, ongoing research topics, as well as plans for future upgrades.
Introduction: HIV guidelines recommend switching from a three-drug regimen (3DR) to dolutegravir + lamivudine (DTG+3TC) for eligible individuals. This retrospective national cohort study used Swedish InfCareHIV registry data to evaluate long-term outcomes of adults with HIV RNA <50 copies/ml who switched to DTG+3TC or a guideline-recommended 3DR between July 2019 and May 2023 in routine clinical c
Background: Dementia is a growing public health concern, and although diet is a modifiable potential risk factor, the role of free sugar intake remains unclear. Excess sugar has been linked to metabolic and cardiovascular dysfunction, both associated with cognitive decline, but evidence regarding specific sugar sources is limited. Objectives: This study aimed to investigate the associations betwee
