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Two families with retinitis pigmentosa showed inheritance of an Arg-16-His ROM1 gene mutation with either an Arg-13-Trp RDS mutation or an Arg-135-Trp RHO mutation. The phenotypes of double and single heterozygotes were determined to examine the hypothesis that digenic inheritance may increase disease expression. In the family with ROM1 and RDS mutations, single heterozygotes were normal but one d
Intrastriatal transplantation of dopaminergic neurones aims to repair the selective loss of nigrostriatal projections and the consequent dysfunction of striatocortical circuitries in Parkinson's disease (PD). Here, we have studied the effects of bilateral human embryonic dopaminergic grafts on the movement-related activation of frontal cortical areas in 4 PD patients using H2 15O positron emission
A novel photodynamic therapy system based on interstitial illumination using multiple fibres is under development. The aim with this system is to enable treatment of large tumour volumes and also to utilise real-time measurements to allow on-line dosimetry. Important dosimetric parameters to measure are light fluence rate, sensitizer fluorescence intensity and local blood oxygenation. A constructi
Zone folded coherent acoustic phonons were generated in a multilayered GaSb/InAs epitaxial heterostructure via rapid heating by femtosecond laser pulses. These phonons were probed by means of ultrafast x-ray diffraction. Phonons both from the fundamental acoustic branch and the first back-folded branch were detected. This represents the first clear evidence for phonon branch folding based directly
A processing scheme for the fabrication of embedded W-GaAs contacts has been established and the resulting contact characteristics have been evaluated. The main advantage of these contacts is that they are stable during high-temperature epitaxial overgrowth. The fabrication scheme is based on a liftoff process with electron beam evaporation of tungsten and subsequent epitaxial overgrowth using met
The objective of present work was to determine and compare the components of bioaerosol in several sectors of plant processing industries. The Study was conducted in 10 Facilities engaged in herb and grain processing, flax threshing, grain storing, baking, and cereals production. The air samples were taken on glass fibre litters with an AS-50 sampler. We determined the concentrations of airborne m
GRACILE (growth retardation, aminoaciduria, cholestasis, iron overload, lactacidosis, and early death) syndrome is a recessively inherited lethal disease characterized by fetal growth retardation, lactic acidosis, aminoaciduria, cholestasis, and abnormalities in iron metabolism. We previously localized the causative gene to a 1.5-cM region on chromosome 2q33-37. In the present study, we report the
A prevalence of hepatitis C virus (HCV) antibodies of 12% was found in 276 patients from 11 dialysis units. Between zero and 22% of the patients in the different units were anti-HCV positive. The epidemiology of HCV was studied in two units during a 2 year period by antibody assays and the polymerase chain reaction and correlated with clinical manifestations. Two types of epidemiologic patterns we
The protein alpha-synuclein is central to the pathophysiology of Parkinson's disease (PD) but its role in the development of neurodegeneration remains unclear. alpha-Synuclein-knockout mice develop without gross abnormality and are resistant to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a mitochondrial inhibitor widely used to model parkinsonism. Here we show that differentiated human do
An early and accurate diagnosis of Alzheimer's disease (AD) is required to initiate symptomatic treatment with currently approved drugs and will be of even greater importance if disease modifying compounds in development display a clinical effect. Protein profiles of human cerebrospinal fluid samples from AD patients (n = 95) and population-based healthy controls (n = 72) were analyzed by SELDI-TO
Purpose: Chromosomal instability (CIN) is believed to have an important role in the pathogenesis of urothelial cancer (UC). The aim of this study was to evaluate whether disturbances of mitotic segregation contribute to CIN in UC, if these processes have any effect on the course of disease, and how deregulation of these mechanisms affects tumor cell growth. Experimental Design: We developed molecu
The > 10,000 living venomous marine snail species [superfamily Conoidea Fleming, 1822] include cone snails (Conus), the overwhelming focus of research. Hastula hectica (Linnaeus, 1758), a venomous snail in the family Terebridae Morch, 1852 was comprehensively investigated. The Terebridae comprise a major monophyletic group within Conoidea. H. hectica has a striking radular tooth to inject venom th
During δ-aminolevulinic acid (ALA) based Interstitial Photodynamic Therapy (IPDT) a high light fluence rate is present close to the source fibers. This might induce an unintentional tissue temperature increase of importance for the treatment outcome. In a previous study, we have observed, that the absorption in the tissue increases during the treatment. A system to measure the local tissue tempera
OBJECTIVES: The effects of occupational and leisure-time exposures on the risk of acute myeloid leukemia (AML) were investigated with emphasis on clonal chromosome aberrations (CCA) and morphological subtypes. METHODS: Consecutively diagnosed cases of AML (N=333) and 1 population referent per case were retrospectively included in the study. Information on worktasks, companies, and leisure-time act
Popular Abstract in Swedish Forskningsprojektet som rapporteras i denna avhandling har två övergripande mål. Det första målet är att utveckla testinstrument avsett för avancerade svenska inlärare av engelska, som genererar reliabla och valida testpoäng kopplat till receptiv kunskap avseende engelska kollokationer som en specifik förmåga. Med kollokationer avses konventionaliserade och frekvent förThe research reported in this thesis has two main aims. The first aim is to develop tests capable of yielding reliable and valid scores of receptive knowledge of English collocations as a single construct, for use with advanced L2 learners of English. Collocations are seen as conventionalized, recurring combinations of words, and the targeted types are adjective + NP and verb + NP. The second aim
Abstract in UndeterminedA correct lighting solution guarantees appropriate working conditions, while saving energy. Today it is well-known that the light influences our visual perception, our emotions and our biological system, thus our health and productivity. Four identical classrooms of a high school in Helsingborg, Sweden, were equipped with two different lighting concepts: classic pendants wi
If we admit that, with the exception of language, human perception is predominantly visual, it is reasonable to think that all phenomena conveyed by the visual senses have something in common, but then visual semiotics/visual culture will comprehend much more than painting, sculpture, and architecture. The double coding hypotheses of cognitive psychology, as well as Lessing’s classical opposition
The Sound Area, located between Sweden and Denmark, is one of the most intensely trafficked waters in the world with complex traffic patterns and a bridge/tunnel under construction, which will link the two countries. This high level of complexity increases the probability of both maritime accidents and very negative consequences of them. This paper presents the ergonomic part of an ongoing multidi
This thesis takes as its point of departure an elective course in English: 'Drama in Practice - Shakespeare on Stage'. The course combines theory and practice in that it contains (on the one hand) lectures and written work about one of Shakespeare’s comedies, and (on the other hand) an on-stage part with rehearsals of the same play, culminating in a performance, in costume, before an audience. The
The purpose was to study age related changes in circulatory system via Ballistocardiography (BCG) by utilizing Electromechanical Film (EMFi) sensors by gradually changing the ambient temperature from a thermoneutral area to cold direction. ECG and BCG were recorded from a young person (23 years) and from an older person (78 years), both males. During the tests, brachium blood pressure (BP) and pul
