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Bladder cancer is three times more common in men than in women. However, the physiological basis of the male predominance of bladder cancer remains poorly understood. A higher than expected association of prostate and bladder cancers has also been reported which may indicate a common mechanism of carcinogenesis. Consistent with this, androgens and the androgen receptor (AR) play essential roles in
Popular Abstract in Swedish Blodförgiftningen (sepsis) kan ge upphov till akut hjärtsvikt, vilken på cellulär nivå karakteriseras av minskad känslighet för kalciumjonen och de vanliga hjärtförstärkande medicinerna (inotropa farmaka). Avhandlingen handlar om tidig behandling av sepsis-associerad hjärtsvikt med den kalciumsensitiseraren levosimendan, ett nytt läkemedel som höjer hjärtats kontraktionSepsis-related cardiovascular dysfunction associated with fluid-unresponsive tissue hypoperfusion might require inotropic treatment. This cardiovascular dysfunction seems to involve calcium desensitization and adrenergic unresponsiveness. We investigated the effects of clinically relevant plasma concentrations of the calcium sensitizer levosimendan during the first 6 h of endotoxemia in a model of
Bioassay experiments were performed two times (with 2 years in between) in order to investigate if nitrogen (N, ammonium), phosphorus (P, phosphate) and carbon (C, glucose) additions would stimulate the growth of bacteria and phytoplankton differently in three different tropical aquatic environments. The water and their indigenous microbial communities were taken from a freshwater coastal lake (Ca
Popular Abstract in Swedish Dagens samhälle är allt mer beroende av elektroniska hjälpmedel så som smarta telefoner, läsplattor, datorer osv. Prestandakraven ökar i en allt högre takt och därför måste även den bakomliggande teknologin följa samma trend. De flesta av oss vill att den nya mobiltelefonen ska ha så hög kameraupplösning som möjligt men få av oss tänker på att detta medför en större mäFast and reliable data transmission together with high bandwidth efficiency are important design aspects in a modern digital communication system. Many different approaches exist but in this thesis bandwidth efficiency is obtained by increasing the data transmission rate with the faster-than-Nyquist (FTN) framework while keeping a fixed power spectral density (PSD). In FTN consecutive information
Popular Abstract in Swedish Det är väl känt att infektioner kan orsaka eller medverka till utveckling av vissa former av cancer hos människan. Cirka 20% av den globala cancerincidensen orsakas av infektioner. Patienter med nedsatt immunförsvar har en ökad förekomst av ett flertal virus-orsakade cancerformer, t.ex. livmoderhalscancer som orsakas av humant papillomvirus (HPV) och levercancer som orsThe identification of infectious agents in cancer has been one of the most rewarding endeavors in cancer research. Currently about 20% of the global cancer burden is linked to an infection. A common characteristic of virus-induced cancer is an increased incidence in immunosuppressed patients, presumably because of impaired host control of virus. Yet non-melanoma skin cancer (NMSC), the cancer that
BACKGROUND: The high prevalence of obesity in children and adolescents emphasizes the necessity to develop evidence-based treatment programs that are useful in a clinical setting. AIMS: The overall aim of the thesis was to develop and evaluate multidisciplinary approaches for management of children and adolescents with obesity. The focus was on generalizability of the treatment in a clinical setti
Type 2 diabetes mellitus (T2DM) results from interaction between genetic and environmental factors. The worldwide prevalence of T2DM is increasing rapidly due to reduction in physical activity, increase in dietary intake, and the aging of the population. This thesis has focused on dissecting the genetic contribution in T2DM using largescale genomic approaches with a particular emphasis on analysis
Popular Abstract in Swedish Populärvetenskaplig svensk sammanfattning Har allvarliga infektioner orsakade av bakterien Haemophilus influenzae försvunnit? En undertyp av H. influenzae, typ b (Hib), var tidigare en fruktad orsak till struplocksinflammation, hjärnhinneinflammation och svår blodförgiftning hos små barn. Problemet var så stort att allmän vaccination mot Hib infördes i många länder i böWhat is the current status of Haemophilus influenzae as an agent of invasive infection in Sweden? H. influenzae type b (Hib) used to be a common cause of meningitis, epiglottitis and severe sepsis in young children. In the late 1980’s an effective conjugated vaccine against Hib was developed and a dramatic fall in Hib incidence was observed in countries that implemented vaccination. This includes
Interpreting the social complexity of the Roman house requires a careful evaluation of existing evidence. With this in mind, recent work in the field has proposed a variety of different approaches, focusing each time on a specific type of source (architecture and décor, ancient texts, material evidence from excavated houses), each in turn recursively deemed more adequate for the purpose or more fr
The health of coastal marine environments is severely declining with global changes. Proxies, such as those based on microeukaryote communities, can record biodiversity and ecosystem responses. However, conventional studies rely on microscopic observations of limited taxonomic range and size fraction, missing putatively ecologically informative community components. Here, we tested molecular tools
Renal cell carcinomas (RCCs) are a group of tumours that arise from the nephron within the kidney. They are characterised by an indolent growth pattern and do not display overt clinical symptoms in patients with early to locally advanced tumours. Furthermore, the global average age of a RCC patient at diagnosis is 75 and they usually present with co-morbidities that may render invasive surgical/bi
There is still quite an unknown and unexploited manuscript of the popular medieval French allegorical poem The Romance of the Rose in Stockholm which is curated in the National Library of Sweden under the number Vu 39. This article has as a goal to give the first information and hypothesis we have about it: the origins of this manuscript which is a version of the XVth Century, a description of its
Fragmentation of habitat, for example by intensive agricultural practices, can be detrimental to local biodiversity. However, it often remains unclear whether such biodiversity declines are caused by loss of habitat area or increased fragmentation, and how habitat quality factors into it. In our study system, vegetated vineyards are typically small, and isolated from one another, potentially limit
Extracellular vesicles (EVs) are derived from the membrane of platelets and released in the circulation upon activation or injury. Analogous to the parent cell, platelet derived EVs play an important role in hemostasis and immune responses by transfer of bioactive cargo from the parent cells. Platelet activation and release of EVs increases in several pathological inflammatory diseases, such as se
Wastewater treatment plant (WWTP) nutrient recovery has recently gained traction in the search for new pathways for fertilizer production. In particular, concentrated waste streams such as reject water from sludge digestion are suitable. The environmental impact of a novel nutrient recovery technology using a membrane contactor (NPHarvest) was examined with an environmental life cycle assessment (
Background and Aims: Inflammatory bowel disease [IBD] has been associated with spondyloarthritis [SpA], but population-based estimates are scarce. Here we compare the occurrence of SpA before and after a diagnosis of IBD with the general population, overall and by IBD subtype and age. Methods: We used a nationwide register-based cohort study of 39 203 patients diagnosed with IBD during 2006-2016,
Neurotensin (NT) is a small protein implicated in the regulation of energy balance which acts as both a neurotransmitter in the central nervous system and as a gastrointestinal peptide. In the gut, NT is secreted after fat ingestion and promotes the absorption of fatty acids. The circulating levels of its precursor, pro-NT, predicts the presence and development of metabolic and cardiovascular dise
Rationale: Allergic asthma is linked to impaired bronchial epithelial secretion of IFNs, which may be causally linked to the increased risk of viral exacerbations. We have previously shown that allergen immunotherapy (AIT) effectively reduces asthma exacerbations and prevents respiratory infections requiring antibiotics; however, whether AIT alters antiviral immunity is still unknown. Objectives:
Aims: The present study aimed at testing the hypothesis that atrial fibrillatory rate (AFR) is predictive of sinus rhythm maintenance after electrical cardioversion. Methods and results: The study comprised 32 patients admitted for cardioversion of atrial fibrillation of short duration (mean duration 3.8 ± 7.7 days). AFR was estimated using frequency power spectrum analysis of QRST-cancelled ECG.
On 20 March 2012, the Polish Council of Ministers adopted Poland’s first Multiannual Development Cooperation Programme. Its title ‘Solidarity, Democracy, Development’ reflects the ongoing debates which surround Polish aid, and the problem with finding an agreement in defining how the Polish Official Development Assistance (ODA) should look. As I will describe in this chapter, since the process of
