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This thesis is a contribution to the understanding of the life and work of Arnold Schoenberg as well as to musical hermeneutics. The aims are (1) to scrutinize Arnold Schoenberg’s marital crisis of the year 1908, (2) to probe into the meanings of some representative musical works during this very period, and (3) to compare features in Schoenberg’s life and his creative work. A number of documents
Climate change poses a serious threat to sustainable urban development, placing many cities at risk. As a consequence, city authorities are increasingly facing the challenge of finding ways to include adaptation strategies into their work, although related knowledge and competence is still scarce and fragmented. With the aim to contribute to knowledge development and organizational learning, the o
Autopsy of sudden cardiac death (SCD) in the young shows a structurally and histologically normal heart in about one third of cases. Sudden death in these cases is believed to be attributed in a high percentage to inherited arrhythmogenic diseases. The purpose of this study was to investigate the value of performing post-mortem genetic analysis for autopsy-negative sudden unexplained death (SUD) i
Popular Abstract in Swedish Papillomvirus (PV) är små virus som förmodligen infekterar alla däggdjur samt fåglar. De papillomvirus som infekterar människa kallas humant papillomvirus (HPV) och kan infektera antingen huden eller slemhinnor. Att livmoderhalscancer orsakas av bestående infektion med HPV har varit känt länge. Man har länge också misstänkt att HPV-infektioner i huden kan orsaka icke-meThe causal relationship between persistent genital infections with human papillomavirus (HPV) and development of cervical cancer is well established. In contrast, the significance of infections with cutaneous HPV for development of non-melanoma skin cancer (NMSC) is not well understood. We have evaluated whether seropositivity to cutaneous HPV is a marker for cutaneous HPV infection and used high
Study I: Thirteen patients underwent a modified Ross operation in which the free-standing pulmonary autograft was supported externally by a Dacron vascular prosthetic jacket (DVPJ). The tailor-made DVPJ prevented dilatation of the neo-aortic root significantly following a median follow-up of 47 months compared to a cohort of l3 matched patients undergoing conventional Ross operation. Study II: A
Streptococcus pyogenes is a major human pathogen with more than 500 000 casualties annually of which at least 163 000 are due to invasive infections. The remainder is due to post-streptococcal complications with rheu¬matic heart disease constituting the majority. S. pyogenes also causes milder infections such as skin infections and pharyngitis with an estimation of more than 700 million cases each
Head and neck cancer is a heterogeneous group of tumours, although histopathologically, >95% are squamous cell carcinomas (SCC). Some tumours respond better to therapy than others. Not enough is known to predict the outcome and tailor individualised treatment. Although one of the main risk factors, smoking, has decreased over the last decades, some head and neck cancer groups show increasing incid
Eeg-Olofsson K, Cederholm J, Nilsson PM, Zethelius B, Svensson A-M, Gudbjornsdottir S, Eliasson B (Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg; Department of Public Health and Caring Sciences/Family Medicine and Clinical Epidemiology, Uppsala University, Uppsala; Department of Clinical Sciences, Lund University, University Hospital, Malmo; Departmen
The competitions for the commission to decorate the Marriage Chamber in Stockholm City Law Courts (1912–1915) have become one of the most important events in the history of mural painting in Sweden. One of the proposals, by artist Isaac Grünewald, has become a major icon of early modernistic art in Sweden. Among the participants in the competition we find some of the most important introducers of
The purpose of this study is to describe and analyse changes in the pledge element of the ordination in the Church of Sweden. The transition in 1893 from a clerical oath to an affirmation will be particularly in focus and its causes and effects identified. My intention is thus to contribute to the history of the Swedish clerical oath, describing its complexity and multifarious range of meaning. In
Popular Abstract in Swedish Parkinsons sjukdom är en av våra vanligaste ålderssjukdomar i Sverige och drabbar en procent av befolkningen över 50 år. De karaktäristiska symptomen: skakningar, långsamma rörelser och stelhet orsakas i huvudsak av en förlust av nervceller som producerar signalsubstansen dopamin i hjärnan. Den mest effektiva behandlingen är L-DOPA, som i hjärnan omvandlas till dopamin.Parkinson's disease and L-DOPA-induced dyskinesia (LID) does not merely involve the dopamine (DA) system but also include non-dopaminergic systems such as glutamate and serotonin (5-HT). An aberrant glutamate transmission at the corticostriatal synapse, has been linked to LID. Pharmacological agents to glutamate receptors at this synapse, (of which some are already clinically tested), could preve
Background. NT-proBNP may be useful for ruling out heart failure in primary health care. In this study we examined the analytical quality of NT-proBNP in primary health care on the Cobas h 232 point-of-care instrument compared with measurements performed in a hospital laboratory. Materials and methods. Blood samples requested for NT-proBNP were collected in primary health care (n = 95) and in a ho
Rheumatoid arthritis (RA) is a systemic disease not only restricted to the joints, but can also be associated with the development of extra-articular manifestations. Extra-articular RA (ExRA) is of clinical importance because of the associated morbidity and increased risk of premature mortality compared with RA patients in general. The aims of this work were to identify patients with ExRA in early
Popular Abstract in Swedish De fyra studier som ingår i denna avhandling är gjorda för att undersöka eventuella oönskade effekter av läkemedel på näthinnan. Näthinnan är en del av det centrala nervsystemet och känslig för toxiska substanser. För att skydda näthinnan så finns två barriärer – en yttre och en inre blod–näthinne- barriär. Dessa barriärer består av strukturer som håller samman celler iThe adverse effects of drugs in the eye are not easily detected, and the underlying pathogenesis not fully understood. The effects of four different kinds of drugs have been investigated in the rabbit eye, using electroretinography, ocular examination and histochemical methods. Rifabutin is a broad spectrum antibiotic with known ocular adverse effects (corneal opacities, uveitis and vascular ret
The Medipix detector is the first device dedicated to measuring mixed-field radiation in the CMS (Compact Muon Solenoid) experiment cavern and able to distinguish between different particle types. Medipix2-MXR chips bump bonded to silicon sensors with various neutron conversion layers developed by the IEAP CTU in Prague were successfully installed for the 2008 LHC start-up in the CMS experimental
Arandomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study. J. Astermark(1), Sh. M. Donfield(2), D. M. DiMichele(3), A. Gringeri(4), S. A. Gilbert(2), J. Waters(2), E. Berntorp(1), for the FENOC Study Group. Department for Hematology and Coagulation Disorders, Malmo, University Hospital, Malmo, Sweden(1); Department of Biosta
Aim. The aim of this paper was to evaluate short-term outcome of the use of endoanchors to secure the primary migrated endograft and additional extender cuffs to the aortic wall in patients with previous failed endovascular aortic aneurysm repair. Methods. Consecutive patients who needed proximal repair of a primary failed endograft due to migration (with or without type IA endoleaks) were treated
Aim: To evaluate the results of ventral intermediate (Vim) thalamic deep brain stimulation (DBS) in patients with tremor predominant Parkinson's disease (PD) at 6 years post surgery. Methods: This was a prolonged follow-up study of 38 patients from eight centres who participated in a multicentre study, the 1 year results of which have been published previously. Total scores as well as scores for i
BACKGROUND: Post-partum hemorrhage (PPH) is the major cause of maternal mortality in Ghana and worldwide. Active management of the third stage of labor (AMTSL) is a globally recommended three-step method that in clinical trials has been proven effective in prevention of PPH. The AMTSL guidelines were introduced in 2003, modified in 2006, and has been part of the national guidelines in Ghana since
Streptococcus agalactiae and Streptococcus pyogenes are two related human pathogens causing different diseases. This thesis focuses on a number of surface proteins expressed by S. agalactiae and S. pyogenes and, more specifically, the molecular and biological characterization of these proteins. The first paper describes the novel Blr protein of S. agalactiae, which together with the previously de
