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2017 year in review Table of Contents Director’s Statement 2 This is RWI 4 RWI Around the World 6 Cambodia’s First Academic Human Rights Centre in Full Swing 8 Legal Clinics Provide Access to Justice for the Poor and Vulnerable 10 Towards Just, Inclusive and Sustainable Development in Asia 12 Supporting Research in Asia 13 Partnership with East African Court of Justice to Continue in New Regional
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MAPPINGMAPPING HOW TO SUPPORT HUMAN RIGHTS HOW TO SUPPORT HUMAN RIGHTS EDUCATION AND RESEARCH IN EDUCATION AND RESEARCH IN UKRAINIAN LAW SCHOOLSUKRAINIAN LAW SCHOOLS Report of the pilot study Arsen Markiv 2023 © 2023 Raoul Wallenberg Institute of Human Rights and Humanitarian Law First Edition (2023) ISBN 978-91-86910-53-2 Author: Arsen Markiv The author would like to thank Morten Koch Andersen, Z
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Crises narratives surrounding the societal challenges of biodiversity loss, climate change, and human health and well-being dominate current debates in global environmental politics. These challenges are deeply interconnected and require transformative and integrated change. Marine and coastal Nature-based Solutions (blue NbS) are an opportunity to minimise harmful human impacts on these ecosystem
Purpose: To investigate the outcome following adjuvant doxorubicin and ifosfamide in a prospective non-randomised study based on a soft tissue sarcoma (STS) patient subgroup defined by specific morphological characteristics previously shown to be at a high-risk of metastatic relapse. The expected 5-year cumulative incidence of metastases in patients with this risk profile has previously been repor
We combine parallaxes from the first Gaia data release with the spectrophotometric distance estimation framework for stars in the fifth RAVE survey data release. The combined distance estimates aremore accurate than either determination in isolation - uncertainties are on average two times smaller than for RAVE-only distances (three times smaller for dwarfs), and 1.4 times smaller than TGAS parall
WD 1145+017 is currently the only white dwarf known to exhibit periodic transits of planetary debris as well as absorption lines from circumstellar gas. We present the first simultaneous fast optical spectrophotometry and broad-band photometry of the system, obtained with the Gran Telescopio Canarias (GTC) and the Liverpool Telescope, respectively. The observations spanned 5.5 h, somewhat longer t
BACKGROUND: Permanent cardiac pacing in children results commonly in augmented energy consumption because of the high pacing rates and the ample stimulation safety margin applied in children. Cardiovascular anatomy and limited venous access sometimes preclude the otherwise preferred endocardial approach. In this multicenter patient series, we studied the feasibility, safety, and energy saving obta
The electronic and magnetic structure of orthorhombic (o-) YMn0.5Fe0.5O3 (YMFO) epitaxial film (space group Pbnm) deposited on the YAlO3 (010) substrate have been investigated using linear polarization-dependent x-ray absorption spectroscopy and magnetization measurements. The magnetic-ordering temperature of around 280 K is observed in o-YMFO film. The x-ray absorption spectra at the Fe-K and the
In response to fasting or hyperglycemia, the pancreatic β-cell alters its output of secreted insulin; however the pathways governing this adaptive response are not entirely established. While the precise role of microRNAs (miRNAs) is also unclear, a recurring theme emphasizes their function in cellular stress responses. We recently showed that miR-184, an abundant miRNA in the β-cell, regulates co
In neuroblastoma, the ALK receptor tyrosine kinase is activated by point mutations. We investigated the potential role of ALK mutations in neuroblastoma clonal evolution.
Gemcitabine requires transporter proteins to cross cell membranes. Low expression of human equilibrative nucleoside transporter-1 (hENT1) may result in gemcitabine resistance in pancreatic ductal adenocarcinoma (PDAC). CO-101, a lipid-drug conjugate of gemcitabine, was rationally designed to enter cells independently of hENT1. We conducted a randomized controlled trial to determine whether CO-101
The complex interaction between cancer cells and the microenvironment plays an essential role in all stages of tumourigenesis. Despite the significance of this interplay, alterations in protein composition underlying tumourstroma interactions are largely unknown. The aim of this study was to identify stromal proteins with clinical relevance in non-small cell lung cancer (NSCLC). A list encompassin
The support for the fight against ‘human trafficking’ has evolved rapidly and comprehensively. There has been, however, no overarching critical evaluation of the efforts to make ‘human trafficking’ a focus of international law. The study addresses this gap and questions the usefulness of the international law definition of human trafficking and the legal framework built around this definition. It
The elemental composition of the St. Louis aerosol has been investigated at rooftop sites in south and central locations in the city as part of the August, 1973 field season of the Regional Air Pollution Study of the U.S. Environmental Protection Agency. Sampling by 5-stage cascade impactor with backup filter permits analysis by proton-induced x-ray emission (PIXE) of size fractions of aerodynamic
gamma-Trace, a small protein occurring in body fluids and in secretory and neuroendocrine cells, was demonstrated by immunohistochemical techniques in the cytoplasm of the tumor cells of 13 pituitary adenomas obtained at surgery and autopsy. Seven of the adenomas also contained LH immunoreactivity. FSH, TSH, and ACTH were each found in one gamma-trace-containing adenoma. gamma-Trace was also demon
Chemotherapy resistance and relapses are common in high-risk neuroblastoma (NB). Here, we developed a clinically relevant in vivo treatment protocol mimicking the first-line five-chemotherapy treatment regimen of high-risk NB and applied this protocol to mice with MYCN-amplified NB patient-derived xenografts (PDXs). Genomic and transcriptomic analyses were used to reveal NB chemoresistance mecha
This thesis applied magnetic resonance imaging (MRI) to investigate to what extent very preterm birth due to early onset fetal growth restriction (FGR) impacts the cardiovascular system and kidneys in adolescence. The thesis further investigated whether FGR exacerbates the organ-specific effects of very preterm birth.Study I validated a widely available non-contrast enhanced MRI method for quantif
Background: Elevated serum levels of growth differentiation factor-15 (GDF-15), is an established risk factor for a range of cardiovascular diseases.We aimed to evaluate the predictive value of plasma GDF-15 as a biomarker for secondary cardiovascular events (CVE) in patients with atherosclerosis undergoing carotid endarterectomy (CEA). Secondly, we determined whether plasma GDF-15 was associated
The initiation of adaptive immunity requires antigen presentation in immune inductive sites. Classical dendritic cells (cDC) sense peripheral immune response inducing cues and migrate to the tissue-draining lymph nodes upon engagement, where they present acquired antigen to cognate T cells. Vaccines include adjuvants, which enable cDC activation and migration, both essential steps in the cascade l
