Filtyp
Background. Systemic sclerosis (SSc) is an autoimmune disease where thickening of the skin can lead to reduced body function and limitations in activities. Severe forms can also affect and seriously damage inner organs. Patient-centred rehabilitation emphasises considerations of patients' background, experience and behavior which highlights the need to know if patient-reported outcome measures (PR
Background: The W allele of the G460W polymorphism in the adducin-1 gene has been occasionally associated with increased blood pressure (BP). The aim of this study was to test whether the G460W variant is associated with BP levels and BP progression rate and whether G460W associations with BP are affected by sex, body mass index (BMI), or age. Methods: The G460W polymorphism was genotyped in the p
Popular Abstract in Swedish Det finns två etablerade sätt att beskriva zigenarnas historia i Sverige. Historien talar antingen om hur illa myndigheterna burit sig åt mot zigenare, eller så berättar historien om zigenarnas självvalda isolering. Gemensamt för beskrivningarna är påståendet att zigenare alltid varit desamma och uppvisar ett likartat levnadssätt genom historien. I denna avhandling studThis thesis analyses Swedish gypsy policy between 1880 and 1970, as part of a larger sociopolitical project undertaken by the Swedish authorities to promote social order and stability. During this period, the treatment of marginalized groups was shaped by the same visions and objectives as for the population as a whole. Gypsies in Sweden have been subject to the same regulations for as other poor
Popular Abstract in Swedish Sammanfattning I debatter och forskning om narkotikapolitik anges den svenska och nederländska modellen ofta som ett motsatspar. Såväl målet för, som utformningen av, narkotikapolitiken har framställts som radikalt olika. Detta synsätt kan sägas vara riktigt. Målet för den svenska narkotikapolitiken är att skapa ett narkotikafritt samhälle. Den nederländska strävar efteIn debates about the Swedish and Dutch drug policies are usually positioned as opposites. The goal for the Swedish drug policy is to create a 'drug-free society'; while in the Netherlands a harm reduction approach prevails. In this study a drug policy is considered a practice of formal social control that can develop differently depending on the contexts in which it emerged. The period studied sta
Popular Abstract in Swedish Bomärken har använts som ägarbeteckning och signatur i Norden in på 1800-talet, och i vissa reliktområden intill nutid. Bomärkena återfinns t.ex. i mantalslängder, jordaböcker och bouppteckningar, men även inskurna på äldre redskap, husgeråd och annat lösöre. Bomärkena har av somliga forskare ansetts ha utformats slumpvis, enbart med syftet att kunna skilja en bomärkesThe pioneering academic research on Merchant Marks (also known as identity marks, personal marks, ownership marks, identification marks, Hausmarken, Hofmarken, Marques de Propriété, bomärken) was done by professor Homeyer (1870). Since 1870 there has been an ongoing debate among scholars whether Merchant Marks are simply formed by chance and coincidence, as stated by Rehnberg (1938, 1951), Scheffe
Streptococcus pyogenes is a common human pathogen causing mild infections such as tonsillitis and pharyngitis, but is also the cause of life-threatening conditions. To be able to infect the human host, S. pyogenes express different virulence factors. The surface-expressed M protein is a major virulence factor of S. pyogenes, mediating resistance to killing by human neutrophils. Results presented i
Organ transplantation provides a treatment of end-stage disease primarily in the kidney, liver and heart. The immunosuppressive treatment regimens of today efficiently prevent early acute rejection; however the long-term survival has not improved to the same extent. Within months/years the majority of transplanted organs develop chronic allograft dysfunction (CAD), associated with fibrosis and int
PURPOSEWe developed three absolute risk models for second primary thyroid cancer to assist with long-term clinical monitoring of childhood cancer survivors. PATIENTS AND METHODSWe used data from the Childhood Cancer Survivor Study (CCSS) and two nested case-control studies (Nordic CCSS; Late Effects Study Group). Model M1 included self-reported risk factors, model M2 added basic radiation and chem
Over 14 000 patients aged 15-24 are estimated to be diagnosed with cancer in the European Union (EU) each year. Teenagers and young adults (TYA) often fall down gaps between children's and adults cancer services. The specific challenges of providing optimal care to them are described, but we present a summary of recent progress. Progress to overcome these challenges is happening at different rates
The carbonic anhydrase (CA) gene family has been reported to consist of at least 11 enzymatically active members and a few inactive homologous proteins. Recent analyses of human and mouse databases provided evidence that human and mouse genomes contain genes for still another novel CA isozyme hereby named CA XIII. In the present study, we modeled the structure of human CA XIII. This model revealed
Magnetic resonance imaging (MRI) may provide attractive biomarkers for assessment of pulmonary disease in clinical trials as it is free from ionizing radiation, minimally invasive and allows regional information. The aim of this study was to characterize lung MRI T1 relaxation time as a biomarker of chronic obstructive pulmonary disease (COPD); and specifically its relationship to smoking history,
Eosinophils natively inhabit the small intestine, but a functional role for them there has remained elusive. Here, we show that eosinophil-deficient mice were protected from induction of Th2-mediated peanut food allergy and anaphylaxis, and Th2 priming was restored by reconstitution with il4(+/+) or il4(-/-) eosinophils. Eosinophils controlled CD103(+) dendritic cell (DC) activation and migration
Neuregulin-1 (Nrg1) is genetically linked to schizophrenia, a disease caused by neurodevelopmental imbalance in dopaminergic function. The Nrg1 receptor ErbB4 is abundantly expressed on midbrain dopaminergic neurons. Nrg1 has been shown to penetrate blood-brain barrier, and peripherally administered Nrg1 activates ErbB4 and leads to a persistent hyperdopaminergic state in neonatal mice. These data
Purpose: Cancers of the digestive system constitute a major risk for childhood cancer survivors treated with radiotherapy once they reach adulthood. The aim of this study was to determine therapy-related risk factors for the development of a second malignancy in the digestive organs (SMDO) after a childhood cancer. Methods and Materials: Among 4,568 2-year survivors of a childhood solid cancer dia
Purpose The aim of this study was to find clinically relevant MIBG-avid metastatic patterns in patients with newly diagnosed stage 4 neuroblastoma. Methods Diagnostic I-123-MIBG scans from 249 patients (123 from a European and 126 from the COG cohort) were assessed for metastatic spread in 14 body segments and the form of the lesions: "focal" (clear margins distinguishable from adjacent background
In this work, we examine how to reliably exploit baseline diversity of a multichannel interferometric SAR system to overcome the layover problem. The problem arises when different height contributions collapse in the same range-azimuth resolution cell, due to the presence of strong terrain slopes or discontinuities in the sensed scene. Several multilook approaches have recently been suggested to c
The use of fluorescence and reflectance spectroscopy in the analysis of cervical histopathology is a growing field of research. The majority of this research is performed with point-like probes. Typically, clinicians select probe sites visually, collecting a handful of spectral samples. An exception to this methodology is the Hyperspectral Diagnostic Imaging (HSDI®) instrument developed by Science
