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The motor effects of gamma-aminobutyric acid (GABA) on the bovine ovarian follicle were studied in vitro using strips from follicle walls. Electrical field stimulation of nerves in the preparation, secured by tetrodotoxin blockade, caused a contraction that was almost totally abolished by phentolamine and only slightly affected by atropine. This mainly adrenergic neurogenic response was inhibited
We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal of our study has been to integrate the complete GWAS results with a large-scale expression quantitative trait loci (eQTL) mapping study in human lung tissues (n = 1,038) to identify candidate causal genes for lung cancer. We performed transcriptome-wide association st
Background: The additional value of including segment 4 (S4) portal branches in right portal vein embolization (rPVE) is debated. The aim of the study was to explore this in a large multicenter cohort. Material and methods: A retrospective cohort study consisting of all patients subjected to rPVE from August 2012 to May 2017 at six Scandinavian university hospitals. PVE technique was essentially t
A growing body of evidence suggests a relationship between oxidative stress and β-amyloid (Aβ) peptide accumulation, a hall-mark in the pathogenesis of Alzheimer's disease (AD). However, a direct causal relationship between oxidative stress and Aβ pathology has not been established in vivo. Therefore, we crossed mice with a knockout of one allele of manganese superoxide dismutase (MnSOD), a critic
Previously, intragenic CAMTA1 copy number variants (CNVs) have been shown to cause non-progressive, congenital ataxia with or without intellectual disability (OMIM#614756). However, ataxia, intellectual disability, and dysmorphic features were all incompletely penetrant, even within families. Here, we describe four patients with de novo nonsense, frameshift or missense CAMTA1 variants. All four pa
Background: Extracorporeal membrane oxygenation (ECMO) is used in severe respiratory and/or circulatory failure when conventional critical care fails. Studies on patients with hematological malignancies on ECMO have shown contradictory results; immunosuppression and coagulopathy are relative contraindications to ECMO. Observations: This nationwide Swedish retrospective chart review identified 958
The viability of a renewable electricity system depends on a relatively small share of hydropower storage resources to regulate climate variations and the spatially uneven distribution of renewable energy. By spatio-temporal coordination of hydropower production over larger regions, the energy storage demand will be reduced and contribute to a “virtual” energy storage gain that in Europe was found
In 2017, the International Headache Society convened a Global Patient Advocacy Summit (GPAS-1) to begin a collaborative effort involving patients, patient advocates, patient advocacy organizations, healthcare professionals, scientists, professional pain, neurology, and headache societies, pharmaceutical manufacturers, and regulatory agencies to advance issues of importance to patients affected by
Introduction: In sports physiotherapy, medicine and orthopaedic randomised controlled trials (RCT), the investigators (and readers) focus on the difference between groups in change scores from baseline to follow-up. Mean score changes are difficult to interpret (is an improvement of 20 units good?'), and follow-up scores may be more meaning
This paper presents the electron and photon energy calibration obtained with the ATLAS detector using about 36 fb -1 of LHC proton-proton collision data recorded at s=13 TeV in 2015 and 2016. The different calibration steps applied to the data and the optimization of the reconstruction of electron and photon energies are discussed. The absolute energy scale is set using a large sample of Z boson d
The usual practice to measure the zero sequence voltage on the D-side of a transformer is to use three voltage transformers (VT), each of them connected between each phase and earth on the primary side and broken-delta connected on the secondary side. In this paper a method is presented for the estimation of the zero sequence voltage on the D-side of a Dy transformer by the use of only one VT conn
År 2015 infördes bristande tillgänglighet som en självständig diskrimineringsform i den svenska diskrimineringslagen, i syfte att stärka delaktigheten i arbetslivet för personer med funktionsnedsättning. Trots reformen visar statistik att skillnader i sysselsättning, arbetsförmåga och upplevd diskriminering fortsatt är betydande i jämförelse med övriga befolkningen. Detta aktualiserar centrala rätIn 2015, lack of accessibility was introduced as a separate form of discrimination in the Swedish Discrimination Act. The reform aimed to improve access to employment for people with disabilities. Despite this change, statistics show that large differences in employment, work capacity and experiences of discrimination remain compared to the rest of the population. This raises important legal quest
Executive summary This master thesis was originally based on a specific assignment given to the authors from ABB Full Service, a unit specializing in providing maintenance outsourcing: “How can ABB Full Service expand its offering of providing fundamental maintenance by seamlessly incorporating the business concept with competencies and solutions from other ABB divisions?” The academic issue was d
Recent studies have explored the influence of obesity and critical illness on ciprofloxacin pharmacokinetics. However, variation across the subpopulation of individuals with obesity admitted to the intensive care unit (ICU) with varying renal function remains unexamined. This study aims to characterize ciprofloxacin pharmacokinetics in ICU patients with obesity and provide dose recommendations for
BACKGROUND: Some pesticides, used in large quantities in current agricultural practices all over Europe, are suspected of adverse effects on human reproductive health (breast and prostate cancers), through mechanisms of endocrine disruption and possible carcinogenic properties, as observed in agricultural settings. However, evidence on dietary pesticide exposure and breast cancer (BC) is lacking f
Popular Abstract in Swedish Varje år insjuknar ca 7000 kvinnor i Sverige i bröstcancer och antalet ökar för varje år. Fortfarande är kunskapen om orsakerna till bröstcancer relativt okända, men många av de kända riskfaktorerna är kopplade till en hög halt av könshormoner i blodet. Faktorer i kosten som kan motverka effekten av könshormonerna är därför av stort intresse. Under 1990-talet inbjöds Diets high in fibre have previously been associated with decreased risk of breast cancer in the Malmö Diet and Cancer cohort. Several potent compounds may exist in high-fibre diets that might protect against breast cancer, for example lignans. Plant lignans are converted to enterolactone by the gut microflora and are similar in structure to estrogens. Enterolactone may interact with the estrogen r
This dissertation examines the construction of monumental synagogues in nineteenth-century Sweden as a means through which Jewish communities articulated public presence, negotiated belonging, and translated aspirations for civic inclusion into durable architectural form. Focusing on five purpose-built synagogues in Gothenburg (1855), Norrköping (1858), Stockholm (1870), Karlstad (1899), and Malmö
Anatase TiO2 is recognized as a promising negative electrode material when employing “water-in-salt” electrolytes in high voltage aqueous lithium-ion batteries. However, the catalytic property of water splitting aggravates the hydrogen evolution reaction, which hinders the formation of a stable solid electrolyte interphase (SEI) on the electrode surface and therefore results in poor cycling perfor
BACKGROUND: Symptom reduction occurring early in depression treatment is associated with favourable post-treatment outcome, but it is not known how early reduction in specific depression symptoms affect treatment outcome. We aimed to determine the impact of symptom-specific change from pre-treatment to week four during internet-delivered CBT (ICBT) on overall and symptom-specific depression severi
