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BACKGROUND: Risk stratification tools for paediatric community-acquired pneumonia (CAP) in well-resourced settings are scarce. We prospectively developed models to predict CAP severity within a multinational cohort of paediatric emergency departments (EDs). Our primary objective was to develop a risk prediction model to discriminate between mild CAP and moderate or severe CAP to assist clinicians
Despite the advent of advanced molecular prognostic tools, it is still difficult to predict the course of disease for cancer patients at the individual level. This lack of predictability is also reflected in many experimental cancer model systems, begging the question of whether certain biological aspects of cancer (eg. growth, evolution etc.) can ever be anticipated or if there remains an inheren
BACKGROUND: Artificial intelligence (AI) is gaining traction in medicine and surgery. AI-based applications can offer tools to examine high-volume data to inform predictive analytics that supports complex decision-making processes. Time-sensitive trauma and emergency contexts are often challenging. The study aims to investigate trauma and emergency surgeons' knowledge and perception of using AI-ba
Introduction: Chemoradiotherapy is standard treatment for limited-stage SCLC. However, most patients relapse and there is a need for better treatment. We investigated whether twice-daily thoracic radiotherapy (TRT) of 60 Gy/40 fractions improves survival compared with the established schedule of 45 Gy/30 fractions. Here, we report final survival data and long-term toxicity. Methods: Randomized, op
Immunotherapy has shown limited success in acute myeloid leukemia (AML), indicating an incomplete understanding of the underlying immunoregulatory mechanisms. Here we identify an immune evasion mechanism present in 60% of AML cases, wherein primitive AML cells aberrantly express the lymphoid surface protein SLAMF6 (signaling lymphocyte activation molecule family member 6). Knockout of SLAMF6 in AM
Cytolysin A (ClyA) is a pore-forming protein from a strongly silenced gene in non-pathogenic Escherichia coli, including typical commensal isolates in the intestinal microbiome of healthy mammalian hosts. Upon overproduction, ClyA-expressing bacteria display a cytolytic phenotype. However, it remains unclear whether sublytic amounts of native ClyA play a role in commensal E. coli-host interactions
Background: Because breast cancer (BC) is molecularly heterogeneous, diagnosis and treatment will likely benefit from comprehensive genetic profiling. However, routine, high-resolution sequencing is not feasible yet, due to implementation challenges associated with whole-genome sequencing of formalin-fixed paraffin embedded (FFPE) BC samples. Therefore, we explored the potential of an alternative
Neuroblastoma (NB) is one of the most lethal childhood cancers due to its propensity to become treatment resistant. By spatial mapping of subclone geographies before and after chemotherapy across 89 tumor regions from 12 NBs, we find that densely packed territories of closely related subclones present at diagnosis are replaced under effective treatment by islands of distantly related survivor subc
A 1D imaging soft X-ray spectrometer installed on the small quantum systems (SQS) scientific instrument of the European XFEL is described. It uses movable cylindrical constant-line-spacing gratings in the Rowland configuration for energy dispersion in the vertical plane, and Wolter optics for simultaneous 1D imaging of the source in the horizontal plane. The soft X-ray fluorescence spectro-imaging
Background: In Europe, approximately 291,000 cardiac arrests occur annually. Despite critical care therapy, hospital mortality remains high. This systematic review assessed whether, in comatose survivors of cardiac arrest, any drug therapy, compared to placebo or usual care, improves outcomes. Methods: We searched Medline, EMBASE, the Cochrane Central Register of Controlled Trials, and The Interna
The biology centered around the TGF-beta type I receptor Activin Receptor-Like Kinase (ALK)1 (encoded by ACVRL1) has been almost exclusively based on its reported endothelial expression pattern since its first functional characterization more than two decades ago. Here, in efforts to better define the therapeutic context in which to use ALK1 inhibitors, we uncover a population of tumor-associated
BACKGROUND: According to the World Health Organization (WHO) the cost of adverse drug reactions (ADRs) in the general population is high and under-reporting by health professionals is a well-recognized problem. Another way to increase ADR reporting is to let the consumers themselves report directly to the authorities. In Sweden it is mandatory for prescribers to report serious ADRs to the Medical
I detta papper försvarar jag Ayn Rands metaetik mot invändningar presenterade av Charles J King. Vad är roten till alla värden? Ayn Rand menar att det är livet som är det yttersta värde och som därför gör alla andra värden möjliga och nödvändiga. Charles J. King delar inte denna uppfattning utan menar istället att det som gör värden möjliga är inte livet, utan förmågan att ha begär. Jag säger att
Objective: We investigated the efficacy and safety of carfilzomib-containing induction before salvage high-dose melphalan with autologous stem-cell transplantation (salvage ASCT) and maintenance with carfilzomib and dexamethasone after salvage ASCT in multiple myeloma. Methods: This randomised, open-label, phase 2 trial included patients with first relapse of multiple myeloma after upfront ASCT wh
Objectives: The augmented inflammatory response to cardiac surgery is a recognized cause of postoperative acute kidney injury. The present study aimed to investigate the effects of preoperative cyclosporine treatment on cytokine production and delineate factors associated with postoperative kidney impairment. Design: A randomized, double-blind, placebo-controlled, single-center study. Setting: At
Due to its proximity, the Orion star forming region is often used as a proxy to study processes related to star formation and to observe young stars in the environment they were born in. With the release of Gaia DR2, the distance measurements to the Orion complex are now good enough that the 3D structure of the complex can be explored. Here we test the hypothesis that, due to non-trivial structure
OKTOBER Hejsan kära läsare! Tänk, nu kommer oktobers nummer av månadsbrevet från Modevetenskapliga Studierådet det är ju helt otroligt vad fort det går. Denna månaden har det varit fullt upp med förberedelser inför det modevetenskapliga programmets 10-årsjubileum som nyss gått av stapeln vilket var något alldeles otroligt att få fira. En punkt i utställningen som hörde jubiléet till var att besöka
https://www.kultur.lu.se/fileadmin/user_upload/kultur/Utbildning/Mode_maanadsbrev/Maanadsbrev_Oktober_2022.pdf - 2026-07-20
Matematikcentrum Matematik NF Sammanställning för MATB24 Linjär analys, ht 2020 Kursansvarig: Yacin Ameur Antal studenter: 37 (detta antal har registrerat sig på kursen enligt ladok). Betyg: Totalt 23 godkända efter första ordinarie tentamen (betyg G eller VG). Utvärdering Sammanfattning av kursvärderingen: Se följande sidor. Lärarnens kommentarer: Pga corona-restriktioner har vi prövat en undervi
https://www.maths.lu.se/fileadmin/maths/Matematik_NF/Kursutvaerderingar/HT2020/MATB24HT2020KA.pdf - 2026-07-20
MNT PAPER TEMPLATE The 2nd EuroSoTL conference, June 8-9 2017, Lund, Sweden Academic Development Programme for Teaching Assistants: Its Influence on Teaching Mindset and Impact on Learning Experiences M.G.S. Tan, R.D. Mendoza, F.S. Lim, P.D. Looker, Nanyang Technological University ABSTRACT: Nanyang Technological University Singapore (NTU) runs a semester-long Teaching Assistants Programme (TAP) a
https://konferens.ht.lu.se/fileadmin/_migrated/content_uploads/Tan_etal.pdf - 2026-07-20
2017 year in review Table of Contents Director’s Statement 2 This is RWI 4 RWI Around the World 6 Cambodia’s First Academic Human Rights Centre in Full Swing 8 Legal Clinics Provide Access to Justice for the Poor and Vulnerable 10 Towards Just, Inclusive and Sustainable Development in Asia 12 Supporting Research in Asia 13 Partnership with East African Court of Justice to Continue in New Regional
https://rwi.lu.se/app/uploads/2018/05/Year-in-Review-2017-2.pdf - 2026-07-20
