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Genome-wide association studies have revealed numerous risk loci associated with diverse diseases. However, identification of disease-causing variants within association loci remains a major challenge. Divergence in gene expression due to cis-regulatory variants in noncoding regions is central to disease susceptibility. We show that integrative computational analysis of phylogenetic conservation w
Proteoglycans (PGs) are macromolecules that consist of long linear polysaccharides, glycosaminoglycan (GAG) chains, covalently attached to a core protein by the carbohydrate xylose. The biosynthesis of GAG chains is initiated by xylosylation of the core protein followed by galactosylation by the galactosyltransferase β4GalT7. Some β-d-xylosides, such as 2-naphthyl β-d-xylopyranoside, can induce GA
The relationship between triacylglycerol and monoacylglycerol hydrolyzing activities of purified rat heart lipoprotein lipase was studied using emulsified trioleoylglycerol and micellar or albumin-bound monooleoylglycerol as substrates. The maximal reaction rates obtained with the two substrates were similar (650 and 550 nmol of fatty acid released per min per mg of protein, respectively). Additio
The combination of density functional theory (DFT) with a multiconfigurational wave function is an efficient way to include dynamical correlation in calculations with multiconfiguration self-consistent field wave functions. These methods can potentially be employed to elucidate reaction mechanisms in bio-inorganic chemistry, where many other methods become either too computationally expensive or t
Purpose: This study explores how information on air pollution is shaped online on an everyday basis, with a particular emphasis on digital devices and digital representations as constitutive of environmental information practices. Furthermore, this research highlights an understudied aspect of air pollution – the digital flow of multimodal representations that citizens encounter and produce in the
A long term experiment was conducted in a primary forest area in Amazonia, with continuous in-situ measurements of aerosol optical properties between February 2008 and April 2011, comprising, to our knowledge, the longest database ever in the Amazon Basin. Two major classes of aerosol particles, with significantly different optical properties were identified: coarse mode predominant biogenic aeros
Transient electromagnetic (TEM) is an efficient non-invasive method to map electrical conductivity distribution in the subsurface. This paper presents an inversion scheme for 3-D TEM time-lapse (TL) data using a generalized minimum support (MS) norm and its application to monitoring conductivity changes over time. In particular, two challenges for TL TEM applications are addressed: (i) the survey
Popular Abstract in French Certaines recherches ont suggéré une différence entre l’acquisition d’une première langue (L1) et celle d’une langue seconde (L2) à l’âge adulte. L’une des questions débattues dans ce domaine est de savoir quand et pourquoi s’arrête l’acquisition du type L1 et quand commence l’acquisition du type L2 adulte. Dans ce débat, un troisième mode d’acquisition, enfant L2 ou bilThis dissertation describes the development of Voice Onset Time (VOT) and liaison in child second language (cL2) French (L1: Swedish) as compared to simultaneous Swedish-French bilinguals (2L1) and monolingual (1L1) French children. VOT is studied in both languages but liaison only exists in French. Differences between L1 and L2 phonology have previously been attributed to a sensitive period for l
beta-1,4-Gatactosyltransferase 7 (beta 4GalT7) is an essential enzyme in the biosynthesis of glycosaminoglycan (GAG) chains of proteoglycans (PGs). Mammalian cells produce PGs, which are involved in biological processes such as cell growth and differentiation. The PGs consist of a core protein, with one or several GAG chains attached. Both the structure of the PGs and the GAG chains, and the expre
This review presents the added value for diagnosis of acute ischemia/infarction of considering ST elevation in the 12 inverted leads (-I, -II, -II, -aVR, etc) of the standard electrocardiogram in addition to ST elevation in 12 positive leads. A small number of studies have been published showing substantial increases in sensitivity at the "cost of' slight decreases in specificity. One recent study
Xyloside analogues with substitution of the endocyclic oxygen atom by sulfur or carbon were investigated as substrates for β-1,4-galactosyltransferase 7 (β4GalT7), a key enzyme in the biosynthesis of glycosaminoglycan chains. The analogues with an endocyclic sulfur atom proved to be excellent substrates for β4GalT7, and were galactosylated approximately fifteen times more efficiently than the corr
The surface electron density significantly affects the photocatalytic efficiency, especially the photocatalytic CO2 reduction reaction, which involves multi-electron participation in the conversion process. Herein, we propose a conceptually different mechanism for surface electron density modulation based on the model of Au anchored CdS. We firstly manipulate the direction of electron transfer by
