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Using population-based data from Sweden, we identified all multiple myeloma (MM) patients (n = 8740) and 5652 monoclonal gammopathy of undetermined significance (MGUS) patients diagnosed between 1986 and 2005. We calculated standardized incidence rates (SIRs) for all subsequent hematologic and nonhematologic malignancies for MM patients diagnosed before/after 1995 (introduction of high-dose melpha

To update the European System for Cardiac Operative Risk Evaluation (EuroSCORE) risk model. A dedicated website collected prospective risk and outcome data on 22 381 consecutive patients undergoing major cardiac surgery in 154 hospitals in 43 countries over a 12-week period (May-July 2010). Completeness and accuracy were validated during data collection using mandatory field entry, error and range

OBJECTIVE: B-type natriuretic peptide (BNP) has been established as a biomarker for heart failure. The objective was to evaluate BNP measured on arrival in the intensive care unit (ICU) as a predictor for heart failure defined as need for inotropic support or IABP beyond 24 hours postoperatively after aortic valve replacement. DESIGN: A prospective, observational study. SETTING: A cardiothoracic s

Background Medical adherence is important in the treatment of depression. Primary medical adherence, i.e. patients collecting their newly prescribed medications from pharmacies, is very different depending on the drug prescribed Objective To assess the rate of primary medical adherence in patients prescribed antidepressants and to identify characteristics that make patients less likely to pick up

Dopamine D2 receptors (D2-R) in extrastriatal brain regions are of high interest for research in a wide range of psychiatric and neurologic disorders. Pharmacological competition studies and test-retest experiments have shown high validity and reliability of the positron emission tomography (PET) radioligand [11C]FLB 457 for D2-R quantification in extrastriatal brain regions. However, this radioli

In recent years, application of ensemble models has been increased tremendously in various types of natural hazard assessment such as landslides and floods. However, application of this kind of robust models in groundwater potential mapping is relatively new. This study applied four data mining algorithms including AdaBoost, Bagging, generalized additive model (GAM), and Naive Bayes (NB) models to

An important question in human genetics is the extent to which genes causing monogenic forms of disease harbor common variants that may contribute to the more typical form of that disease. We aimed to comprehensively evaluate the extent to which common variation irk the six known maturity-onset diabetes of the young (MODY) genes, which cause a monogenic form of type 2 diabetes, is associated with

BACKGROUND: An increasing incidence of penicillin-resistant Streptococcus pneumoniae (PRP) was detected in Malmo in 1994. OBJECTIVE: To evaluate clonality and factors facilitating the spread of PRP among children in day-care centers (DCCs). METHODS: We used phenotypic and DNA-fingerprinting methods in conjunction with epidemiologic data from the South Swedish Pneumococcal Intervention Project's in

Motor complications of Parkinson's disease (PD) are a consequence of pulsatile dopaminergic stimulation from standard oral levodopa therapy. Levodopa-carbidopa intestinal gel (LCIG) is infused continuously via an intrajejunal percutaneous gastrostomy tube. This was the first study designed to characterize the full pharmacokinetic profiles of levodopa, carbidopa, and levodopa metabolite, 3-O-methyl

Optical and micro-physical features of aerosol are reported using Skyradiometer (POM-01L, Prede, Japan) observations taken from a high-altitude station Merak, located in north-eastern Ladakh of the western trans-Himalayas region during January 2011 to December 2013. The observed daily mean aerosol optical depth (AOD, at 500 nm) at the site varied from 0.01 to 0.14. However, 75 % of the observed AO

Research on InterStellar Objects (ISOs) has been done for several decades, however, the first observed ISO in the Solar system was only recently discovered in 2017. It was named 1I/'Oumuamua and was only passing though the Solar system, but this may not be the case for all objects of its kind. For instance, one could gain a bound orbit around the Sun if the right amount of nudge is acquired wh

In the fifth generation of mobile communication, 5G, frequencies above 30 GHz, so-called millimeter-wave (mm-wave) frequencies are expected to play a prominent role. For the synthesis of these frequencies, the all-digital phase locked loop (ADPLL) has recently gained much attention. A core component of the ADPLL is the digitally controlled oscillator (DCO), an oscillator that tunes the frequency d

This report presents the work developing a modular sailboat interior system that offers an easy and affordable way for recreational sailors to customize the interiors of their sailboats according to their different and changing needs. Cruising sailboats are like floating houses or cottages, with the difference that the interior is permanent. They have a long product life and often last for decade

With significant changes expected in the earth's global climate over the next century, due to global warming, and its resulting changes in the frequency and amount of precipitation, there has been growing concerns on climate change impacts on water resources. Especially concerned to water managers and governments is the potential impacts on groundwater aquifers since they are the main availabl

Vilka mangroverötter vill marina djur helst bo på? Stora delar av världens tropiska kuster är bevuxna av mangrove. Här vadar träden i vattnet och skjuter hela tiden ut nya luftrötter för att ta över ytterligare en bit hav. Inte så många skulle få för sig att snorkla på en sådan här plats. Gör man ändå det möts man, åtminstone i Karibien, av en explosion av färger och liv. Alger och mängder av fasEffect of habitat heterogeneity on marine epibiont assemblages associated with mangrove roots In coastal forests of red mangrove, prop roots extend into the seawater and serve as substrate for assemblages of algae and sessile marine organisms. These assemblages exhibit extreme variability on very small special scales – two neighbouring prop roots might be colonized by completely distinct assembla

En ökad medvetenhet om värdet av ett rent grundvatten yttrar sig i allt fler sammanhang, bl.a. i det nationella miljömål om grundvatten av god kvalitet som riksdagen presenterat. Simrishamns kommun ser över vattenskyddsområdena runt kommunens grundvattentäkter för att säkerställa ett rent grundvatten. Målet med detta examensarbete är att ta fram ett underlag som skall kunna ligga till grund för avThe increased awareness of the value of clean groundwater can be seen in a growing number of contexts. This is also emphasized in the national environmental goals, put up by the Swedish government. The municipality of Simrishamn, in southern Sweden, is re-evaluating the extension of the existing restriction areas around the groundwater wells of the municipality. The aims in this investigation were

Context. Measuring the abundances of neutron-capture elements in Galactic disk stars is an important part of understanding key stellar and galactic processes. In the optical wavelength regime a number of different neutron-capture elements have been measured; however, only the s-process-dominated element cerium has been accurately measured for a large sample of disk stars from the infrared H band.

Objectives: Urinary incontinence (UI) is a very common condition in the primary healthcare settings. Few studies have investigated whether sociodemographic factors are related to UI. This nationwide study aimed to investigate whether there is a relationship between sociodemographic factors and UI in women. Methods: A nationwide open cohort study included 2,044,065 women aged 15–50 years. Several n