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Complement is a cascade-like system that is part of the innate immune defence. It is an explosive system, potentially harmful also for the host cells, and needs to be strictly regulated. An important down-regulator of complement is C4b-binding protein (C4BP). C4BP contains two different types of subunits, seven identical a-chains and one unique P-chain. The alpha-chains bind to C4b, C4BP's target
The 3.1- and 3.7-km-deep FFC-1 and DGE-1 geothermal explorations wells drilled into the Precambrian crystalline basement on the southern margin of the Fennoscandian Shield are evaluated regarding experiences from drilling, geological conditions, and thermal properties. Both wells penetrate an approximately 2-km-thick succession of sedimentary strata before entering the crystalline basement, domina
Rationale: Untreated obstructive sleep apnea (OSA) is associated with adverse outcomes in patients with coronary artery disease (CAD). Continuous positive airway pressure (CPAP) is the most common treatment, but despite interventions addressing established adherence determinants, CPAP use remains poor. Objectives: To determine whether physiological traits that cause OSA are associated with long-te
Background: The implementation of screening programmes in Sweden during the mid-1990s increased the number of small node-negative breast cancers. In this era before staging by sentinel node biopsy, routine axillary dissection for staging of early breast cancer was questioned owing to the increased morbidity and lack of perceived benefit. The long-term risk of axillary recurrence when axillary stag
The quantitative relationship between exposure to physical risk factors and upper extremity work-related musculoskeletal disorders (UE-WMSDs) is virtually unknown. To explore the variation, objective measurements were derived in 43 types of work (686 individuals), using goniometry for the wrists and electromyography (EMG) for the forearm extensor muscles. The variations due to work were great for
Despite the increasing level and number of techniques deployed to generate more robust, better-producing microbial cell factories for production of chemicals, the number of products that reach commercial feasibility is still very low. Many hurdles come along the way as it has been observed that strains designed in the laboratory do not perform as expected in industrial-scale bioreactors. For insta
For historical reasons, Swedish railways use 15 kV/16? Hz overhead contact lines for train traction, while the most common standard worldwide is 25 kV/50-60 Hz. This leads to higher investment costs for railway conversions and expansions, and to greater energy losses in the distribution of electricity to the trains. Yet to get away from these drawbacks by investing in a 25 kV/50 Hz overhead contac
This thesis is a combined conceptual study and preliminary design of two study options for a future tramway line between Trädgårdsgatan and Hälsovägen in Helsingborg. This line is of great interest since it’s centrally located and regarded as a problematic stretch of narrow streets, heavy traffic and steep gradients. In addition, a local tramway line in Helsingborg is regarded as a priority projec
Context. The second release of Gaia data (Gaia DR2) contains the astrometric parameters for more than half a million quasars. This set defines a kinematically non-rotating reference frame in the optical domain. A subset of these quasars have accurate VLBI positions that allow the axes of the reference frame to be aligned with the International Celestial Reference System (ICRF) radio frame. Aims. W
Objective: To determine the frequency of mutations known to cause autosomal dominant Parkinson disease (PD) in a series with more than 10% of Sweden's estimated number of PD patients. Methods: The Swedish Parkinson Disease Genetics Network was formed as a national multicenter consortium of clinical researchers who together have access to DNA from a total of 2,206 PD patients; 85.4% were from popul
Background: Despite many atrial fibrillation (AF) patients being at risk of bleeding, very limited data are available on bleeding rates of different direct oral anticoagulants based on the spectrum of bleeding risk. Objective: We aimed to compare the risk of major bleeding and thromboembolic events with apixaban vs rivaroxaban for AF patients stratified by bleeding risk. Methods: We conducted a po
BACKGROUND: Centrally inserted central catheters (CICCs) are indispensable in modern healthcare, but unfortunately, come with complications. Catheter-related thrombosis is a well-known complication reported to occur in 5-30% of patients with CICC. There is a paucity of studies that report the incidence of catheter-related thrombosis after the introduction of real-time ultrasound insertion guidance
BACKGROUND:: Exposure to second-hand smoke has been shown to be associated with increased cardiovascular mortality in several, but not all, epidemiologic studies. Our aim was to investigate the risk of circulatory death associated with exposure to second-hand smoke in never-smokers in a very large prospective study, the European Prospective Investigation into Cancer and Nutrition. A secondary aim
AIM: Factors associated with unexpected absence or presence of coronary atherosclerosis in individuals at high/low estimated cardiovascular (CV) risk are largely unexplored. We assessed two extreme phenotypes: 1) no coronary atherosclerosis despite very high CV risk; and 2) severe-extensive coronary atherosclerosis despite low CV risk.METHODS: A multicenter, cross-sectional nationwide, population-
Adolescent girls are particularly susceptible to iron deficiency due to increased iron requirements during the pubertal growth spurt, combined with iron loss following menarche. This study aimed to investigate the prevalence of heavy menstrual bleeding in an adolescent population using the SAMANTA questionnaire and to explore its relationship with dietary habits and iron deficiency. This cross-sec
Abstract – Introduction: Peripheral intravenous catheterization is commonly required in sick neonates but remains challenging due to small vessels, leading to multiple attempts and complications. This review evaluated the benefits and harms of device-assisted techniques versus standard technique. Methods: We searched MEDLINE, Embase, CENTRAL, Cochrane Reviews, WHO ICTRP, and ClinicalTrials.gov (Oc
The main goal of the project was to decrease the cooling time of a diamond anvil cell (DAC) by modifying an existing design. Modifications included change of materials, overall dimensions and a significant reduction of mass together with additional suggestions for decreased cool time. The initial design was known to function with current materials and dimensions. The first step of the thesis was
Det här är ett masterarbete kring relationen mellan ADHD och musik, inte inom medicin. Med arbetet vill jag lyfta upp fördelar, hyperförmågor och den stora kreativa potential som ADHD ger mig som musiker. Jag fick ADHD-diagnosen först efter flera års studier på Musikhögskolan, och hade innan dess levt 30 år med bara nackdelar med ADHD. Eftersom jag var missnöjd med medicinen tänkte jag “out of theFinding my inner Nimrud - my life as an ADHD musician This is a master's thesis on the relationship between ADHD and music, not in medicine. With this work, I aim to highlight the advantages, hyper-abilities and great creative potential that ADHD give me as a musician. I got the ADHD diagnosis after 4 years of study at the Academy of Music. Before that I lived 30 years with only the disadvanta
In this work spectroscopic methods have been used to determine the effect of fluorophores on protein affinity. Fluorophores are used in many different contexts to mark proteins, genes or antibodies. By marking a construct with a fluorophore, it is possible to follow the localization and function in a biological system, but it is not often investigated how the bound fluorophore could affect the mar
1 LUNDS UNIVERSITET Institutionen för arkeologi och antikens historia _______________________________________________________________________________________________________________________________________________________ Kurslitteratur för ARKB05, Arkeologisk fältmetodik, digital dokumentation och GIS, 30 hp Fastställd av institutionsstyrelsen 2024-12-10 Litteraturen söks i LUBcat och/eller LUBse
https://www.ht.lu.se/media/utbildning/dokument/kurser/ARKB05/20261/Litteraturlista_ARKB05_241210.pdf - 2026-06-11
