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Introduction: The rate of vaginal hysterectomies is declining globally. We investigated surgical techniques, outcomes, and costs in a large national cohort of benign hysterectomies with prerequisites for vaginal surgery. Material and Methods: A retrospective register-based cohort study with benign hysterectomies in the Swedish GynOp registry 2014–2023 (n = 17 804). Inclusion criteria were non-prol
The work presented in this thesis aims at improving spectroscopic techniques for analysis of pharmaceutical solids. This improvement is achieved by the combining and development of instrumentations and data evaluation tools from two research fields: the fields of near infrared spectroscopy and biomedical optics. The thesis include the construction and evaluation of different variable selection te
Complement is a cascade-like system that is part of the innate immune defence. It is an explosive system, potentially harmful also for the host cells, and needs to be strictly regulated. An important down-regulator of complement is C4b-binding protein (C4BP). C4BP contains two different types of subunits, seven identical a-chains and one unique P-chain. The alpha-chains bind to C4b, C4BP's target
This project is set at the crossing of two burning topics of our time: the often ignored problematics of displaced people around the world; and the recently much more debated question of global warming. That these seemingly diverse thematics are deeply connected with each other becomes clear just by reading the IPCC* report from 2007 on global warming. As this report suggests, the real danger lies
Tillgång till tillräckliga mängder vatten av god kvalitet är en väsentlig resurs för samhället. Det behövs för mänsklig konsumtion, för produktion i industrin, för fisket, etcetera. Det är därför mycket oroande att vattenkvaliteten i Europeiska unionen successivt försämras. Östersjön som är mycket påverkad av övergödning kan nämnas som ett exempel. Övergödning orsakas av utsläpp av näringsämnen iThe supply of good quality water is an essential resource for society. It is needed for human consumption, for production processes in the industry, for fishing, etcetera. The fact that the quality of waters within the European Union is continuously deteriorating is therefore of major concern. One example is the Baltic Sea, which is heavily affected by eutrophication. Eutrophication is caused b
This thesis is a combined conceptual study and preliminary design of two study options for a future tramway line between Trädgårdsgatan and Hälsovägen in Helsingborg. This line is of great interest since it’s centrally located and regarded as a problematic stretch of narrow streets, heavy traffic and steep gradients. In addition, a local tramway line in Helsingborg is regarded as a priority projec
Popular Abstract in Swedish Akupunktur är en mer än 2000 år gammal terapeutisk metod, som ingår i den traditionella kinesiska medicinen (TCM), för lindring av en del sjukdomar och symtom såsom smärta. Tunna, solida nålar instickes i så kallade akupunkturpunkter, oftast belägna i muskulaturen och utspridda över hela kroppen längs linjer som kallas meridianer. Det finns ett flertal olika sätt att teIn a retrospective follow-up study, n=202, long-term pain relief (>6 months) after a course of acupuncture treatments was found mainly among patients with chronic nociceptive pain while patients with neurogenic or psychogenic pain did not benefit much. In a placebo-controlled randomised single-blind long-term study with independent observer of chronic nociceptive low back pain, n=50, it was found
BACKGROUND: Patients with diabetes have increased rates of major adverse cardiac events (MACEs). We hypothesized that this is explained by diabetes-associated differences in coronary plaque morphology and lipid content. METHODS: In PROSPECT II (Providing Regional Observations to Study Predictors of Events in the Coronary Tree), 898 patients with acute myocardial infarction with or without ST-segme
IMPORTANCE: Perforated colonic diverticulitis usually requires surgical resection, which is associated with significant morbidity. Cohort studies have suggested that laparoscopic lavage may treat perforated diverticulitis with less morbidity than resection procedures. OBJECTIVE: To compare the outcomes from laparoscopic lavage with those for colon resection for perforated diverticulitis. DESIGN, S
Background: Despite many atrial fibrillation (AF) patients being at risk of bleeding, very limited data are available on bleeding rates of different direct oral anticoagulants based on the spectrum of bleeding risk. Objective: We aimed to compare the risk of major bleeding and thromboembolic events with apixaban vs rivaroxaban for AF patients stratified by bleeding risk. Methods: We conducted a po
Importance: Early identification of the likelihood of autism spectrum disorder (ASD) using minimal information is crucial for early diagnosis and intervention, which can affect developmental outcomes. Objective: To develop and validate a machine learning (ML) model for predicting ASD using a minimal set of features from background and medical information and to evaluate the predictors and the util
The novel Coronavirus disease 2019 (COVID-19) presents a major threat to public health but can be prevented by safe and effective COVID-19 vaccines. Vaccine acceptance among healthcare workers (HCWs) is essential to promote uptake. This study, aimed to determine the COVID-19 vaccination uptake and hesitancy and its associated factors among HCWs in Tanzania. We employed a convergent-parallel mixed-
Context. The second release of Gaia data (Gaia DR2) contains the astrometric parameters for more than half a million quasars. This set defines a kinematically non-rotating reference frame in the optical domain. A subset of these quasars have accurate VLBI positions that allow the axes of the reference frame to be aligned with the International Celestial Reference System (ICRF) radio frame. Aims. W
This mapping provides an overview of different types of arenas where the two concepts Ecosystem-based adaptation (EbA) and Blue Carbon (BC) are discussed. EbA has been defined by the Convention on Biological Diversity (CBD) as “The use of biodiversity and ecosystem services as part of an overall adaptation strategy to help people to adapt to the adverse effects of climate change.” (CBD, 2009). BC
Popular Abstract in Swedish Denna avhandling analyserar frågor som berör tillfälliga jobb på den svenska arbetsmarknaden under perioden 1990-1999. Ett viktigt bidrag i avhandlingen är att den stora gruppen tillfälliga jobb delas upp i mindre undergrupper för att ta i beaktande den heterogenitet som finns mellan olika former av tillfälliga jobb. En röd tråd som löper genom hela avhandlingen är fokuThis thesis analyses different aspects of temporary jobs in the Swedish labour market during 1991-1999. Throughout the thesis we put special focus on differences between the genders, and differences between native-born and foreign-born workers. In chapter 1, An Introduction to Temporary Jobs in Sweden, we describe the evolution of different types of temporary jobs in Sweden during the 1990s, we re
BACKGROUND:: Exposure to second-hand smoke has been shown to be associated with increased cardiovascular mortality in several, but not all, epidemiologic studies. Our aim was to investigate the risk of circulatory death associated with exposure to second-hand smoke in never-smokers in a very large prospective study, the European Prospective Investigation into Cancer and Nutrition. A secondary aim
Background: Targeted temperature management is recommended after out-of-hospital cardiac arrest and may be achieved using a variety of cooling devices. This study was conducted to explore the performance and outcomes for intravascular versus surface devices for targeted temperature management after out-of-hospital cardiac arrest. Method: A retrospective analysis of data from the Targeted Temperatu
Background-Diabetes mellitus (DM) and cardiovascular disease are associated with dyslipidemia, but the detailed lipid molecular pattern in both diseases remains unknown. Methods and Results-We used shotgun mass spectrometry to determine serum levels of 255 molecular lipids in 316 controls, 171 DM, and 99 myocardial infarction (MI) events from a cohort derived from the Malmö Diet and Cancer study.
IMPORTANCE Prostate cancer commonly metastasizes to bone, and bone metastases are associated with pathologic fractures, pain, and reduced survival. Bone disease is routinely visualized using the technetium Tc 99m(99mTc) bone scan; however, the standard interpretation of bone scan data relies on subjective manual assessment of counting metastatic lesion numbers. There is an unmet need for an object
Objective To compare PET imaging of tau pathology with CSF measurements (total tau [t-tau] and phosphorylated tau [p-tau]) in terms of diagnostic performance for Alzheimer disease (AD). Methods We compared t-tau and p-tau and 18 F-AV-1451 in 30 controls, 14 patients with prodromal AD, and 39 patients with Alzheimer dementia, recruited from the Swedish BioFINDER study. All patients with AD (prodrom
