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Objective. Antileukoproteinase (ALP) is a physiologic inhibitor of granulocytic serine proteases. The present study was undertaken to investigate its therapeutic benefit in an antibody-transfer model of erosive polyarthritis and to elucidate its potential to interfere with immune complex-dependent inflammatory pathways. Methods. Arthritis development was induced in male (BALB/c x B10.Q)F-1 mice by
Background: Nigeria is a major contributor to the global malaria burden. The genetic diversity of malaria parasite populations as well as antibody responses of individuals in affected areas against antigens of the parasite can reveal the transmission intensity, a key information required to control the disease. This work was carried out to determine the allelic frequency of highly polymorphic Plas
Background: 4-1BB (CD137) is a co-stimulatory receptor highly expressed on tumor reactive effector T cells and NK cells, which upon stimulation prolongs persistence of tumor reactive effector T and NK cells within the tumor and induces long-lived memory T cells. 4-1BB agonistic antibodies have been shown to induce strong anti-tumor effects that synergize with immune checkpoint inhibitors. The firs
IgA nephropathy (IgAN) and Henoch-Schönlein purpura (HSP) are diseases characterized by IgA deposits in the kidney and/or skin. Both may arise after upper respiratory tract infections, but the pathogenic mechanisms governing these diseases remain unclear. Patients with IgAN (n = 16) and HSP (n = 17) were included in this study aimed at examining whether IgA-binding M proteins of group A streptococ
It has previously been shown that sera from multiparous women have increased levels of anti-idiotypic antibodies specific for anti-HLA molecules. γ-Globulins prepared from these sera may be superior to commercial preparations of intravenous γ-globulin (IVIg) for inhibiting HLA alloimmunization. To test this, F(ab′)2 fragments prepared from either commercial IVIg or from the sera of men or multipar
Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,
Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad antimicrobial activity. In the present study, we describe a previously unknown antimicrobial mode of ac
Syllabus SMMV26 Organising Sustainability This is a translation of the syllabus which was established in Swedish. STYR 2025/1953 Faculty of Social Sciences SMMV26, Organising Sustainability, 7.5 credits Organisera hållbarhet, 7,5 högskolepoäng Second Cycle / Avancerad nivå Details of approval The syllabus was approved by the board of the Department of Service Management and Service Studies on 2019
https://www.ses.lu.se/en/sites/ses.lu.se.en/files/2025-09/Kp_SMMV26_eng_VT26_rev_250829.pdf - 2026-06-30
The intense debate on continuity in child grammars has largely focused on the existence of Functional Categories (FCs) in early grammars despite differences in language use with adults (e.g., omissions, word order errors, lack of case marking). Simplified, the major theoretical explanations for these properties range from Maturational accounts (Radford 1990 and later) claiming an initial absence o
Receptet på en fantastisk antikropp – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Receptet på en fantastisk antikropp 2024-06-26 Bilden illustrerar två IgG-liknande antikroppar som binder till ett protein. Forskarna Pontus Nordenfelt och Arman Izadi är något av antikr
https://www.vetenskaphalsa.se/receptet-pa-en-fantastisk-antikropp/ - 2026-06-30
Bilaga 1 Verksamhetsberättelse 2017 för EDS Nordic User Group Vid EDS Nordic User Groups årsmöte 2017-03-22 i Luleå valdes följande styrelsemedlemmar: ordförande Cilla Öhnfeldt, Stockholms universitet (omval), Per Falk, Högskolan i Gävle (nyval), Ann- Christin Persson, Lunds universitet (nyval), Tove Andersson, Region Skåne (nyval), Mikael Arvidsson, Karlstads universitet (omval) och Eva Sejmyr, L
https://www.ub.lu.se/sites/ub.lu.se/files/verksamhetsberattelse_2017_for_eds_nordic_user_group.pdf - 2026-06-30
Drupal offers a wide range of possibilities for creating web forms, but it is also a large and complex tool. For example, you can create web forms to conduct surveys, collect expressions of interest for a conference, or as a way for visitors to get in touch with your organisation – but to create effective web forms, you need a basic understanding of how web forms in Drupal work.Web forms and web f
https://www.webbpublicering.lu.se/guides-english/web-form - 2026-06-29
Abstract in German Die Methode der ökologischen Kreuzvalidierung dient der Analyse der Beziehung zwischen Entscheidungsmodell und Umwelt. Dabei wird im Gegensatz zu traditionellen Formen der Kreuzvalidierung eine theoretisch-inhaltliche Unterscheidung zwischen Kalibrierungs- und Validierungsdaten vorgenommen. Die Performanz ausgewählter Entscheidungsmodelle bei der Validierung wird in Situationen
MSH2 rearrangements are involved in approximately 10% of hereditary non,polyposis colorectal cancer (HNPCC) families, and in most of the rearrangements, exon I is deleted. We scanned by quantitative multiplex polymerase chain reaction (PCR) of short fluorescent fragments (QMPSF) 200 kb of genomic sequences upstream of the MSH2 transcription initiation site in 21 HNPCC families with exon I deletion
1 Rechtsstaatlichkeit Ein Leitfaden für Politikerinnen und Politiker 2 Copyright © The Raoul Wallenberg Institute of Human Rights and Humanitarian Law and the Hague Institute for the Internationalisation of Law 2012 ISBN: 978-91-86910-82-2 Die Verbreitung dieser Veröffentlichung unterliegt der Bedingung, dass sie nicht ohne vorherige Zustimmung der Herausgeber in einer anderen Ausfüh- rung und Ges
https://rwi.lu.se/app/uploads/2014/02/Rechtsstaatlichkeit.pdf - 2026-06-30
Background: Many inborn errors of metabolism (IEMs) may present as sudden infant death (SID). Nowadays, increasing numbers of patients with IEMs are identified pre-symptomatically by population neonatal bloodspot screening (NBS) programmes. However, some patients escape early detection because their symptoms and signs start before NBS test results become available, they even die even before the sa
