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Immune checkpoint inhibitors have drastically improved the prognosis for several cancer patients, but still the exact underlying mechanism behind cancer immune escape and the role of individual immune cell populations remains poorly understood. Thus, further insights into the level of immune cell infiltration in cancers, their functional role, level of activation and maturity are warranted in orde

This essay concerns the assessment of penal value in cases regarding narcotic offenses. It particularly concerns the level of guilt as shown by the court for the criminal act and associated factors. In the early 1960's the punishment for narcotic offences were fines or inprisonment for up to two years in accordance with narcoticregulation. With the adoption of the narcotic penal law the maxim

Hem och A1M – ett test på liv och död Hem är en av kroppens viktigaste hjälpar-molekyler. När hem är bundet till proteiner hjälper det cellerna att utvinna energi och rensa ut gifter. Det mesta hemet finns i de röda blodkropparna där hem används till att transportera syre i kroppen. Tyvärr är obundet hem giftigt. Det har visat sig att havandeskapsförgiftning, ett tillstånd som kan drabba gravida,

I skrivande stund är sju olika cancercentra i Sverige, däribland Skånes Universitetssjukhus i Lund, mitt uppe i en gemensam randomiserad studie som undersöker behandling av prostatacancer med två olika strålningsscheman. Patienterna i studien blir slumpvis tilldelade antingen en standardbehandling, där de får en liten mängd strålning vid 39 olika tillfällen, eller en så kallad hypofraktionerad behPurpose: This work examined the feasibility of flattening filter free (FFF) volumetric modulated arc therapy (VMAT) for extreme hypofractionation of prostate cancer. The aim was to investigate the potential gain in treatment time per fraction for extreme hypofractionation of prostate cancer, while preserving or improving the treatment plan quality and radiation delivery quality. The impact of intr

The aim of this study was to optimize a function starch-ethyl cellulose film for targeting the therapeutically active substance to the colon in the disease state for patients suffering from inflammatory bowel diseases. This study includes: • The preparation of the polymeric films and the investigation of the characterization (for example mechanical properties, water uptake, dry mass loss, and mic

Behandling av kroniska tarmsjukdomar Är PTPN23 lösningen vi har väntat på? Alla har vi sannolikt någon gång lidit av magproblem i form av smärta eller diarré. Att drabbas av kroniska tarmsjukdomar där besvären utgör en vardag är ett globalt problem, och trots att sjukdomarna är vanliga finns idag inget botemedel. I den här studien har vi undersökt om en eliminering av molekylen PTPN23 från makrofThe gastrointestinal tract encounters foreign antigens, commensal bacteria and nutrients on a daily basis. Under steady state conditions, a regulatory immune system maintains gut homeostasis. However, disruption of the balance between regulatory components and defeating invading pathogens leads to overshooting inflammatory reactions that can culminate in chronic and relapsing intestinal inflammati

Föräldrabalkens 6 kap. 2 a § stadgar att barnets bästa skall vara avgörande för alla beslut i frågor om vårdnad, boende och umgänge. Barnets bästa är en princip som går att finna i såväl internationella dokument som i nationell lagstiftning. Begreppet barnets bästas innebörd är ej uttryckligen definierad i varken de internationella dokumenten, såsom barnkonventionen, eller i svensk nationell lagstAccording to the Swedish parental code 6 chapter 2 a §, the best interest of the child shall be conclusive for all decisions in matters of custody, residency and right to access. The best interest of the child is a principle which can be found in both international documents and in national legislation. The concept of the principle of the best interest of the child is not expressly defined in neit

‘Safety pays’ is a phrase commonly used. But, when it comes to putting that concept into practice, very few are actually successful at it. Reasons given include: it is costly or it is a waste of time or it is not the main cause of failure. However the real problem is that there is not enough guidance as to how to improve safety performance on site. Traditional measurement approaches include accide

In standard crystallographic refinement of biomacromolecules, the crystallographic raw data are supplemented by empirical restraints that ensure that the structure makes chemical sense. These restraints are typically accurate for amino acids and nucleic acids, but less so for cofactors, substrates, inhibitors, ligands and metal sites. In quantum refinement, this potential is replaced by more accur

This thesis examines how forced digitized work has affected politicians in a regional board. Through interviews with elected politicians and observations of council meetings we have studied and analyzed the politicians’ attitudes towards the forced digitized changeover. The digitalization that was forced due to the corona pandemic has been perceived differently and can be linked to the idea of dig

Instruction for external experts regarding programme evaluation at the Faculty of Social Sciences Page 1 of 7 Faculty Board DECISION Reg. No. STYR 2021/118 2021-02-04 Instruction for external experts regarding programme evaluation at the Faculty of Social Sciences This decision enters into force on 4 February 2021 and replace and invalidate the previous decision on Instructions for external expert

https://www.sam.lu.se/en/internal/sites/sam.lu.se.en.internal/files/2021-03/Instructions%20for%20external%20experts%20regarding%20programme%20evaluation%20at%20the%20Faculty%20of%20Social%20Sciences_2021.pdf - 2026-04-26

Global solar radiation (GSR) prediction capability with a reliable model and high accuracy is crucial for comprehending hydrological and meteorological systems. It is vital for the production of renewable and clean energy. This research aims to evaluate the performance of combined variational mode decomposition (VMD) with a multi-functional recurrent fuzzy neural network (MFRFNN) and quantile regr

Treatment of met-myoglobin (Fe-III) with H2O2 gives rise to ferryl myoglobin, which is closely related to compound II in peroxidases. Experimental studies have given conflicting results for this species. In particular, crystallographic and extended x-ray absorption fine-structure data have shown either a short (similar to170 pm) or a longer (similar to190 pm) Fe-O bond, indicating either a double

Varje år sker det tusentals olyckor i trafiken i Sverige till följd av det stora transportbehovet i samhället. Transportstyrelsen har ett mål, Nollvisionen, som innebär att ingen ska dödas eller skadas allvarligt i trafiken. För att nå målet är en åtgärd att hastigheten sänks där gång- och cykeltrafik behöver interagera med motorfordon. Det kan man göra i form av sidoförskjutningar, avsmalning av Every year, thousands of traffic accidents occur in Sweden as a result of the transportation need in society. The Swedish Transport Agency has a goal, Vision Zero, which means that no one should die or be severely injured in traffic. To reach the goal one measure is to reduce the speed where pedestrians and cyclists need to interact with motor vehicles. This can be done by chicanes, narrowing of t

The Water hyacinth is one of the worst aquatic weeds in the world and it is today present on all continents except Antarctica. It causes big problems for both people and the aquatic ecosystems in many countries. A lot of research has been completed to find methods to eradicate the weed and a lot of money has been spent on management to keep waters clean. In this literature study on management meth

Microsoft Word - CALL FOR ABSTRACTS BTB 6 220926 with logo-nh-1.docx CALL FOR ABSTRACTS Symposium at Lund University, Sweden, March 16-17, 2023 Arranged by the Birgit Rausing Centre for Medical Humanities at Lund University, Sweden and the Department for the History, Philosophy and Ethics of Medicine, Centre for Health and Society, Heinrich-Heine University Düsseldorf, Germany Bridging the Baltic

https://www.medicinhistoria.lu.se/sites/medicinhistoria.lu.se/files/2022-10/CALL%20FOR%20ABSTRACTS%20Digital%20Health-symposium%20March%202023.pdf - 2026-04-26

Så vill de korta vägen till livräddande cell- och genterapier – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Så vill de korta vägen till livräddande cell- och genterapier 2026-02-18 Trots banbrytande forskning når många cell- och genterapier inte hela vägen till patienterna. Forskare och

https://www.vetenskaphalsa.se/ny-lundamodell-vill-korta-vagen-till-livraddande-cell-och-genterapier/ - 2026-04-25

A mobile stroke unit (MSU) is an advanced ambulance equipped with specialized technology and trained healthcare personnel to provide on-site diagnosis and treatment for stroke patients. Providing efficient access to healthcare (in a viable way) requires optimizing the placement of MSUs. In this study, we propose a time-efficient method based on a genetic algorithm (GA) to find the most suitable am

Popular Abstract in English The gene encoding a β-glucosidase originating from the extreme thermophile Thermotoga neopolitana has been cloned and expressed in Escherichia coli. The aim was to produce a thermostable enzyme that could be used to remove sugar residues from glucosylated natural products classified as flavonoids by applying a method combining extraction in hot pressurized water with enThe gene encoding a β-glucosidase originating from the extreme thermophile Thermotoga neopolitana has been cloned and expressed in Escherichia coli. The aim was to produce a thermostable enzyme that could be used to remove sugar residues from glucosylated natural products classified as flavonoids by applying a method combining extraction in hot pressurized water with enzymatic hydrolysis. The β-g