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A generalist vector-transmitted parasite exhibits population genetic structure among host genera

Generalist parasites experience selective pressures from the various host species they infect. However, it is unclear if parasite transmission among host species precludes the establishment of host-specific adaptations and population genetic structure. We assessed the population genetic structure of the vector-transmitted avian haemosporidian parasite Haemoproteus majoris (lineage WW2; n = 34 infe

Primary immunodeficiency in southern Sweden. Strategies for diagnosis and clinical management

Popular Abstract in Swedish Immunsystemet är ett invecklat och komplext system som finns överallt i kroppen och som inte är begränsat till ett enda organ. Vi utsätts hela tiden för ”angrepp” från mikro-organismer (t.ex. bakterier eller virus) men också för främmande ämnen som kan vara skadliga eller giftiga. Immunsystemets huvudfunktion är att hjälpa kroppen att känna igen dessa ”angripare” och atThe overall aim of this PhD project was to gain insight into the incidence of primary immunodeficiency (PID) in southern Sweden and to optimize diagnostic and treatment measures for these patients. We estimated the occurrence rate of PID in the pediatric population of southern Sweden during a period of 4 years and described the demographic, clinical and immunological characteristics of the identif

Female urinary incontinence. A study on heredity, urodynamic and hormonal factors and the evaluation of a novel surgical technique

Popular Abstract in Swedish Ofrivilligt urinläckage, urininkontinens, omfattar mer än 50 miljoner människor i världen, varav cirka 500 000 i Sverige. Av dessa beräknas 2/3 vara kvinnor. Ofrivilligt urinläckage är ett medicinskt och socialt handikapp för den drabbade, operation och hjälpmedel förorsakar samhället stora kostnader. Risken för urininkontinens ökar med stigande ålder. I svenska studierAbstract Pelvic floor disorders (PFD) represent a major public health issue worldwide. Aims of this work Study I: to investigate associations between preoperative resting urethral parameters (MUCP, FL and CA) and objective outcome of laparoscopic colposuspension and, if possible, to identify cutoff values useful in clinical practice. Study II: to investigate a group of perimenopausal women reporti

Riskerna med framförande av maskiner i byggbranschen

Bakgrund: I bygg- och anläggningsbranschen skedde 1470 olyckor år 2018 där några även ledde till dödlig utgång (Arbetsmiljöverket, 2018). Utbildningen till maskinförare idag är både lång men grundlig och ger maskinföraren de förutsättningar som krävs för att framföra ett anläggningsfordon på ett säkert sätt på en byggarbetsplats. Genom regleringar från arbetsmiljöverket och förebyggande åtgärder aBackground: In the construction industry a total 1470 accidents occurred 2018 where some of them also led to fatal outcome (Arbetsmiljöverket, 2018). The qualification to be a construction machine operator are both long and thorough and will give the operator the prerequisites to convey the construction machine in a safe way on different construction sites. Through regulations from Arbetsmiljöverk

Digital China Project Descriptions

Data Capitalism – Do Digital Footprints Change Power Relations in China? (Stefan Brehm) China's Digital Memory-scape (Karl Gustafsson) Policy innovation and e-government in China (Christian Göbel) Children´s use of ICT in China (Annika Pissin) ICT and education in China (Barbara Schulte) Managing use of new technologies in changing institutional and network contexts: The case of ICT firms in China

https://www.ace.lu.se/research/completed-major-research-projects/digital-china/digital-china-project-descriptions - 2026-04-25

Computational Tools for Splicing Defect Prediction in Breast/Ovarian Cancer Genes : How Efficient Are They at Predicting RNA Alterations?

In silico tools for splicing defect prediction have a key role to assess the impact of variants of uncertain significance. Our aim was to evaluate the performance of a set of commonly used splicing in silico tools comparing the predictions against RNA in vitro results. This was done for natural splice sites of clinically relevant genes in hereditary breast/ovarian cancer (HBOC) and Lynch syndrome.

Manners and etiquette for hybrid teaching

Hybrid is what we call meetings, seminars or lectures that have both physical and digital participants. It might be the case that a majority of students attend a lecture on site and a few students attend from home – or vice versa. Hybrid teaching has become a relatively common format at University but it comes with several challenges. Therefore, it’s important to think through a meeting in advance

https://www.campusonline.lu.se/en/studying-digitally/manners-and-etiquette-hybrid-teaching - 2026-04-25

Impact of Surgery for Primary Hyperparathyroidism

Primär hyperparathyroidism, pHPT, är en relativt vanlig endokrinologisk sjukdom som karaktäriseras av förhöjd utsöndring av bisköldkörtelhormon, PTH, i förhållande till kalciumnivån i blodet. Sjukdomen är vanligast hos äldre och kvinnor, och orsakas oftast av en godartad tumör i en bisköldkörtel (80–85% av fallen) eller mer diffus förstoring av flera bisköldkörtlar. Bisköldkörtlarnas fysiologiska

The interconnected KIT receptor and Microphthalmia-associated transcription factor axis in melanoma

Melanoma is an aggressive disease that arises from deregulated signaling events in melanocytes. The KIT receptor tyrosine kinase and the Microphthalmia-associated transcription factor (MITF) are two essential components that are required for the normal physiology of melanocyte development and function. Consequently, aberrant activities of these factors are involved in the development of melanoma.

Domain swapping as a molecular mechanism in amyloidosis

Popular Abstract in Swedish Som en blixt från klar himmel drabbas en ung, och till synes frisk person, av hjärnblödning. Denna stroke leder till demens och efterföljande nya blödningar leder slutligen till en för tidig död. Man har kunnat visa att denna sjukdom beror på att en variant av ett visst protein, cystatin C, tvinnar ihop sig till rep-liknande långa fibriller. Dessa fibriller ansamlas sedAmyloidosis is a group of diseases characterized by a change in protein conformation resulting in aggregation and tissue deposition of amyloid fibrils. One variant of cystatin C, L68Q cystatin C, is highly amyloidogenic and persons carrying the corresponding gene suffer from massive cerebral amyloidosis leading to brain hemorrhage and death. Amyloidogenic proteins like cystatin C and prion protein

Mechanisms of Transgene Silencing in Neural Cells -Implications for Ex Vivo Gene Therapy to the Brain

The use of genetically modifi ed neural stem and progenitor cells could possibly be a future strategy for repairing a brain suffering from neurodegeneration. However, so far it has proven diffi cult to maintain sufficient levels of a transferred gene in suitable cell types, after transplantation. In the present thesis I studied the silencing of transgenes induced upon differentiation of neural pro

Functional analysis of cultured retinal cells

Undersökning av näthinneceller odlade på ljuskänsliga nanotrådar Människans sinnen bombarderas ständigt med nya intryck. En stor del av dessa förmedlas via vår syn. Ljus kommer in i ögat och absorberas av ljuskänsliga fotopigment som finns i de yttre segmenten av näthinnans fotoreceptorer. Näthinnan är uppbyggd av flera olika skikt och av flera olika celltyper, både nervceller och stödjande gliacWorldwide, millions of people suffer from retinal degenerative diseases leading to cell death of light absorbing photoreceptors. This results in vision impairment and, in many cases, eventually blindness. A possible solution for patients gone legally blind due to retinal degeneration, is the use of retinal implants. The best performing retinal implants of today, regarding vision acuity, still give

Half-sandwich Metal Complexes with Salicylaldimine Ligands and Tricarbonyl Metal Complexes with Pyridinmethanimine Ligands

Malaria är en sjukdom som orsakas av parasiter av plasmodium släktet och överförs mellan människor av myggor. Då myggan biter en malariasmittad människa och förtär dess blod så innehåller detta blod parasiter som i senare sprids ifrån myggans mage och vidare till dess salivkörtlar. När myggan vid ett senare tillfälle biter en frisk människa, överförs parasiten från salivkörtlarna till människans bMalaria is a massive global health crisis that is most prevalent in tropical regions of Africa, Asia, and Latin America. The World Health Organization (WHO) estimated in 2013 that 3.3 billion people were at risk of being infected by the disease, resulting in around 200 million cases with more than 500 000 of these cases leading to lethal outcome. Africa was by far the most affected by the disease

Endogenous Programs and Flexibility in Bird Migration

Endogenous programs that regulate annual cycles have been shown for many taxa, including protists, arthropods, fish, mammals and birds. In migration biology, these programs are best known in songbirds. The majority of songbirds rely on a genetic program inherited from their parents that will guide them during their first solo-migration. The phenotypic components of the program are crucial for thei

Geophysical Investigations of a Rural Water Point Installation Program in Nampula Province, Mozambique

There are many projects in Mozambique for poverty reduction. One of these projects is funded by Millennium Challenge Account (MCA) and is aimed to install a total of 600 rural water points in the provinces of Nampula and Cabo Delgado. Each water point consists of a drilled well, a water pump and a communal washing basin. Vertical Electrical Sounding (VES) was used for assessing the uitability of

Visual Orientation and Navigation in Nocturnal Arthropods.

With their highly sensitive visual systems, the arthropods have evolved a remarkable capacity to orient and navigate at night. Whereas some navigate under the open sky, and take full advantage of the celestial cues available there, others navigate in more difficult conditions, such as through the dense understory of a tropical rainforest. Four major classes of orientation are performed by arthropo

Synchronous growth releases in peatland pine chronologies as an indicator for regional climate dynamics-a multi-site study including estonia, Belarus and Sweden

Fourteen tree-ring chronologies developed from 788 peatland Scots pines sampled at sites in Estonia, Belarus and Sweden were compared for common growth trends and possible links to regional climate dynamics. Several synchronous growth release events were detected, especially during the 1910s, 1930s, and around 1970 and 1990, indicating that hydrological shifts and associated tree growth responses

Combining the GW Approximation with the Hubbard I Approximation for strongly correlated materials

In this thesis, the GW approximation (GWA, Green's function G times screened interaction W) and the Hubbard I approximation (HIA) are combined in a non-self-consistent one-shot calculation to determine the electronic structure of a one-dimensional strongly-correlated model. The scheme was chosen to incorporate both screening effects through the GWA and strong on-site correlations through the a

All kraft på att bekämpa barncancer – Vetenskap och Hälsa

All kraft på att bekämpa barncancer – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök All kraft på att bekämpa barncancer 2020-11-16 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Utanför de olika intagningsrummen på barnonkologen avdelning 64, hänger inplast

https://www.vetenskaphalsa.se/all-kraft-pa-att-bekampa-barncancer/ - 2026-04-26

Ny genterapi kan rädda livet på barn med svår ärftlig sjukdom – Vetenskap och Hälsa

Ny genterapi kan rädda livet på barn med svår ärftlig sjukdom – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Ny genterapi kan rädda livet på barn med svår ärftlig sjukdom 2023-12-13 Den ovanliga genetiska sjukdomen MLD drabbar främst yngre barn och har tills nyligen inneburit stort lidand

https://www.vetenskaphalsa.se/ny-genterapi-kan-radda-livet-pa-barn-med-svar-arftlig-sjukdom/ - 2026-04-25