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Human dihydroorotate dehydrogenase (DHODH) catalyzes the fourth step of the de novo pyrimidine biosynthesis pathway and uses ubiquinone Q10, a lipophilic molecule located in the inner mitochondrial membrane (IMM), as its co-substrate. DHODH is anchored to the IMM by a single transmembrane helix located at its N-terminus. Nevertheless, how DHODH function is determined by its surrounding membrane en

Reliable quantitative vegetation reconstructions for Europe during the Holocene are crucial to improving our understanding of landscape dynamics, making it possible to assess the past effects of environmental variables and land-use change on ecosystems and biodiversity, and mitigating their effects in the future. We present here the most spatially extensive and temporally continuous pollen-based r

Nitrogenase is the only enzyme that can cleave the strong triple bond in N2, making nitrogen available for biological life. There are three isozymes of nitrogenase, differing in the composition of the active site, viz., Mo, V, and Fe-nitrogenase. Recently, the first crystal structure of Fe-nitrogenase was presented. We have performed the first combined quantum mechanical and molecular mechanical (

Rapidly developing viral resistance to licensed human immunodeficiency virus type 1 (HIV-1) protease inhibitors is an increasing problem in the treatment of HIV-infected individuals and AIDS patients. A rational design of more effective protease inhibitors and discovery of potential biological substrates for the HIV-1 protease require accurate models for protease cleavage specificity. In this stud

Popular Abstract in Swedish Paternalism i allmänläkarens vardag - om läkarens makt och patientens rätt till självbestämmande. I mitt vardagliga arbete som allmänläkare möter jag patienter med olika symtom och sjukdomar. Hur bör allmänläkaren förhålla sig till en patient som ställer krav på en åtgärd – en speciell undersökning, ett recept på en viss medicin eller ett intyg – som läkaren inte finneThe overall aim of this thesis was to identify and analyse situations raising the question of possible paternalism in everyday general practice in Sweden. Both questionnaires to a random sample of respondents and interviews have been used. The ethical awareness among GPs in Sweden and the variety of ethical issues, suggest that medical ethics is a subject of high relevance in general practice. Th

The objective of this paper is to analyse the Constructive Dialogue, an initiative for collaborative and integrated urban governance for a sustainable built environment. The dialogue processes, implemented in six Swedish cities in 2004-2009, involved various actors and many types of initiative. Designed as a meta-analysis based on existing evaluations and supplementary interviews, this study exami

Background: Uveal melanoma is the most common primary intraocular malignancy in adults. Despite successful control of the primary tumor, metastatic disease will ultimately develop in approximately 50% of patients, with the liver being the most common site for metastases. The median survival for patients with liver metastases is between 6 and 12 months, and no treatment has in randomized trials eve

Pathologic aggregation of beta-amyloid (A beta) peptide and the axonal microtubule-associated protein tau protein are hallmarks of Alzheimer's disease (AD). Evidence supports that A beta peptide accumulation precedes microtubule-related pathology, although the link between A beta and tau remains unclear. We previously provided evidence for early co-localization of A beta 42 peptides and hyperphosp

An experimental investigation was performed to evaluate convective condensation and evaporation of R22, R32 and R410A inside a smooth tube (inner diameter 11.43 mm), a herringbone tube (fin root diameter 11.43 mm) and a newly developed enhanced surface EHT tube (inner diameter 11.5 mm) at low mass fluxes. The inner surface of the EHT tube is enhanced by dimple/protrusion and secondary petal arrays

C4b-binding protein (C4BP) is best known as a potent soluble inhibitor of the classical and lectin pathways of the complement system. This large 500kDa multimeric plasma glycoprotein is expressed mainly in the liver but also in lung and pancreas. It consists of several identical 75kDa α-chains and often also one 40kDa β-chain, both of which are mainly composed of complement control protein (CCP) d

The natural products pulchrol and pulchral, isolated from the roots of the Mexican plant Bourreria pulchra, have previously been shown to possess an antiparasitic activity toward Trypanosoma cruzi, Leishmania braziliensis and L. amazonensis, protozoa responsible for the Chagas disease and leishmaniasis. These infections have been classified as neglected diseases, and still require the development

Insects contribute considerably to global crop pollination, with pollination deficits being documented for multiple entomophilous or pollinator-dependent crops. Different cultivars of crops are being cultivated within and across production regions, so it is essential to understand the cultivar variability of pollination deficits. Here, we used a dataset from 286 sites from multiple production regi

Caroline Eliasson Avfall – en av framtidens viktigaste resurser Avfallshanteringen har i både Sverige och EU genomgått stora förändringar de senaste åren. Ny lagstiftning och nya styrmedel har implementerats och gett gott resultat genom att minska mängden avfall som deponeras. Nästa utmaning är att kunna utnyttja materialet i avfallet mer än en gång. För det krävs nya strategier. AvfallshanterThe thesis consists of a description of the waste management in Sweden today, related to a case study at IKEA’s warehouses in Älmhult. Waste is globally one of the most important environmental challenges. Waste management in Sweden has developed a lot during the past years and is now standing in front of the next big challenge: to reach higher up in the waste hierarchy. By studying the academic li

Background: One of the preanalytical factors that can affect the results of arterial blood gas (ABG) analysis is the time from sample collection to analysis. A delay in analysis may affect the results due to factors such as ongoing cellular metabolism within the blood sample, gas exchange between the blood sample and the environment, and temperature changes. ABG analysis can be delayed for various

Pedestrians and cyclists are so-called unprotected road users which are sensitive in the context of road safety. When it comes to road safety focus are often placed on pedestrians-cars and cyclist-cars, in this report focus are placed on the road safety between pedestrians and cyclists. Pedestrians and cyclists are often referred to a combined space, with or without a separation. The purpose of th

I detta arbete har jag valt att göra en utredning av huvudsaklighetskravet i Äktenskapsbalk (1987:230) 7 kap. 4 §. Huvudsaklighetskravet är ett begrepp som tillämpas då makarnas egendom vid en skilsmässa skall fördelas på lotter. Detta begrepp omfattar såväl den gemensamma bostaden som bohaget, men i detta arbete tar jag bara upp vad som gäller den gemensamma bostaden. Under efterkrigstiden var de

Handlingsplan för hållbar utveckling 2023-2026 Sida 1 av 13 Naturvetenskapliga fakulteten Carin Jarl Sunesson HANDLINGSPLAN Diarienummer STYR 2022/2870 Datum 2023-01-12 Handlingstyp: 2.3.2 Handlingsplan Ämnesområde: Hållbar utveckling Handlingsplan för hållbar utveckling 2023 – 2026 Bakgrund Fakulteter och motsvarande verksamheter ska upprätta handlingsplaner som beskriver ansvarsfördelning, rolle

https://www.naturvetenskap.lu.se/internt/sites/naturvetenskap.lu.se.internt/files/2023-02/Handlingsplan%20fo%CC%88r%20ha%CC%8Allbar%20utveckling%202023%20%E2%80%93%202026.pdf - 2026-05-03

Så kan gentekniken påverka vår hälsa – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Så kan gentekniken påverka vår hälsa 2020-11-06 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Illustration: Elena Sharipova Redan i juni 2000, då ett första ”utkast” av mä

https://www.vetenskaphalsa.se/sa-kan-gentekniken-paverka-var-halsa/ - 2026-05-02

Empati var ett ideal i 1800-talets behandling av psykisk ohälsa Empati var ett ideal i 1800-talets behandling av psykisk ohälsa Av Gisela Lindberg - Publicerad den 18 juni 2024 Behandlare utövar animal magnetism. Källa Wikimedia. Samma frågor som ställs inom dagens psykoterapi och psykiatri ställdes av behandlare under 1800-talet och tidigt 1900-tal. Tvärtemot vad vi kanske tror var medkänsla ett

https://www.historiska.lu.se/article/empati-var-ett-ideal-i-1800-talets-behandling-av-psykisk-ohaelsa/ - 2026-04-06