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Background Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling. Methods In a collaborative met

Haemophilia patients with inhibitors characteristically have impaired joint function and reduced health-related quality of life (HRQoL). This analysis examined whether secondary prophylaxis with recombinant activated factor VII (rFVIIa) improves HRQoL vs. conventional on-demand therapy in patients with haemophilia with inhibitors and frequent bleeds. After a 3-month preprophylaxis period, 22 patie

Low temperature scanning tunneling microscopy (STM) studies of metal-free phthalocyanine (H2Pc) adsorbed on highly oriented pyrolytic graphite (HOPG) have shown ordered arrangement of molecules for low coverages up to 1 ML. Evaporation of H2Pc onto HOPG and annealing of the sample to 670 K result in a densely packed structure of the molecules. Arrangements of submonolayer, monolayer, and monolayer

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. At an early stage of the disease, AF may terminate spontaneously and is then referred to as paroxysmal AF. On the other hand, when external intervention is required for the arrhythmia to terminate, it is referred to as persistent AF. In this work, a method to discriminate between paroxysmal and persistent AF in the long-t

Objective: To study factors associated with health-enhancing physical activity in people with rheumatoid arthritis (RA), stratified by physical function. Method: In 2017, a survey was sent to 1543 patients with RA in the BARFOT (Better Anti-Rheumatic Pharmacotherapy) cohort, and 69% of patients responded. The survey included questions on physical function, pain, fatigue, self-reported disease acti

Background: In recent decades, virtual care has emerged as a promising option to support primary care delivery. However, despite the potential, adoption rates remained low. With the outbreak of COVID-19, it has suddenly been pushed to the forefront of care delivery. As we progress into the second year of the COVID-19 pandemic, there is a need and opportunity to review the impact remote care had in

Purpose: The purpose is to investigate how the coronavirus disease 2019 (COVID-19) pandemic changed relocation behavior in an advanced economy. We compare manufacturing relocations before and during the pandemic to identify differences and similarities over time and between offshoring and backshoring. Design/methodology/approach: We use an exploratory longitudinal trend survey approach with data f

Purpose: Although both relaxation and diffusion imaging are sensitive to tissue microstructure, studies have reported limited sensitivity and robustness of using relaxation or conventional diffusion alone to characterize tissue microstructure. Recently, it has been shown that tensor-valued diffusion encoding and joint relaxation-diffusion quantification enable more reliable quantification of compa

Clusters are particles which consist of a finite number (2 − 10 ^6−7 ) of atoms/molecules. For the work presented in this thesis free clusters have been produced in order to study their properties, free of interfering substrates, using photoelectron spectroscopy at the MAX-lab synchrotron facility in Lund, Sweden. The clusters were produced using a magnetron-based sputtering source and are conside

Objective: To evaluate long-term oncological outcome and surgical quality of robotic radical hysterectomy for cervical cancer. Methods: Consecutive women with stage IA2 to IIA operated between March 2006 and May 2012 with a robotic radical hysterectomy and pelvic lymphadenectomy were prospectively followed up until five years after surgery or until death. Details regarding clinical results, recurr

This study investigates the relation between preferences and cognitive effort in decision making tasks in a natural setting. Does the way a supermarket’s shelves are organized affect how easy it is to choose what items to purchase? Does it affect the quality of our choice? The eye-movements of participants were recorded during their regular shopping trips in two supermarkets with different shelf

3-dimensionell (3D) rekonstruktion, ett område inom datorseende, har under senare år gjort stora framsteg som en konsekvens av de omfattande genombrott som har skett inom Artificiell Intelligens (AI). Inom datorseende har man som mål att försöka förklara hur världen ser ut för en dator, där saker som vi människor finner uppenbara behöver beskrivas i detalj med matematiska begrepp för att datorn sk3D reconstruction is a field in computer vision which has evolved rapidly as a result of the recent advancements in deep learning. As 3D reconstruction pipelines now can run in real-time, this has opened up new possibilities for teams developing Advanced Driver Assistance Systems (ADAS), which rely on the camera system of the vehicle to enhance the safety and driving experience. This thesis pres

Uppsatsen handlar om kvalitén på den nya skattelagstiftningen om omvänd skattskyldighet på mobiltelefoner som tillkommit i syfte att stävja karusellhandel, vilket är en typ av mervärdesskattebedrägeri. Den nya skattelagstiftningen om omvänd skattskyldighet på mobiltelefoner trädde i kraft den 1 april 2021 och har stöd i mervärdesskattedirektivets artikel 199a. För att analysera kvalitén på den nysThe thesis is about the quality of the new tax legislation on reverse tax liability on mobile phones that has been added for the purpose of curbing carousel trading (Sw: karusellhandel), which is a type of VAT fraud. The new tax legislation on reverse charge on mobile phones entered into force on 1 April 2021 and is supported by Article 199a of the VAT Directive. To analyze the quality of the tax

Miljö- och klimatfrågor blir alltmer aktuella i samhället. Såväl konsumenter som företag och internationella organisationer lägger större fokus på dessa frågor. Exempelvis använder företag ofta miljöpåståenden i sin marknadsföring, det vill säga påståenden som skapar intrycket att en produkt har en positiv inverkan, saknar inverkan eller har en mindre inverkan på miljön än andra produkter. DärtillEnvironmental and climate issues are becoming increasingly relevant in society. Both consumers and companies, as well as international organizations are placing greater focus on these issues. For example, companies often use environmental claims in their marketing, making statements that create the impression that a product has a positive impact, no impact or a lesser impact on the environment com

Populärvetenskaplig sammanfattning: När Sveriges Geologiska Undersökning (SGU) karterade nordöstra Skåne påträffades dels kalksediment i ett annars gnejsdominerat område, dels ett gyttjeliknande manganförande material i en husbehovstäkt i Broestorp, 2 km SSV om Sibbhult, NO Skåne. Syftet med min undersökning var att dokumentera och bestämma bildningen för moränskärningarna i täkten, utbredningen aThe study was made in Broestorp gravel pit with surroundings, 2 km SSV of Sibbhult, Southern Sweden. The tills and the underlying Cretaceous bedrock were investigated in a drumlin-shaped ridge striking approximately N30°E-S30°V and being 1000 m long and 150-250 m wide. Different types of manganiferous and ferruginous precipitates were found to be enriched at the contact between Cretaceous bedrock

Med utgångspunkt i unionsrättslig praxis syftar arbetet att undersöka ompaketeringsundantagets innebörd och dess tillämpning i svenska domstolar. Inledningsvis ges en allmän beskrivning av parallellimport och läkemedelsmarknaden och därefter undersöks etablerandet av ompaketeringsundantaget och dess innebörd. EUD har fastställt att även om fördraget inte berör förekomsten av immateriella rättigheThis essay investigates the trade mark doctrine for parallel importation of repackaged pharmaceuticals established in community law, and how this doctrine is applied in Swedish courts. Initially the author generally describes parallel imports and the pharmaceutical market before investigating the establishment of the doctrine and its meaning. The ECJ have established that whilst the treaty does n

The JUNGFRAU 4-megapixel (4M) charge-integrating pixel-array detector, when operated at a full 2 kHz frame rate, streams data at a rate of 17 GB s-1. To operate this detector for macromolecular crystallography beamlines, a data-acquisition system called Jungfraujoch was developed. The system, running on a single server with field-programmable gate arrays and general-purpose graphics processing uni

SPI1 (also known as PU.1) is a dominant but transient regulator in early T-cell precursors and a potent transcriptional controller of developmentally important pro-T-cell genes. Before T-lineage commitment, open chromatin is frequently occupied by PU.1, and many PU.1 sites lose accessibility when PU.1 is later down-regulated. Pioneering activity of PU.1 was tested in this developmentally dynamic c