Sökresultat

This work explores the catalytic activity of decavanadate (V10)-based catalysts in the selective oxidation of ethylbenzene (EB), a model compound of lignin-derived molecules, under mild conditions. The goal is to assess the catalytic efficiency, product selectivity, and the influence of counter-ions on activity through systematic testing of parameters such as temperature and catalyst loading. Addi

This study examines the production of morphosyntax in Swedish-speaking children diagnosed with Developmental Language Disorder (DLD). Data from a Sentence Repetition Task was used to investigate if there is an implicational order according to Processability Theory (PT) in grammatical structures produced by school-age children with DLD. PT is a cognitive theory of language development that assumes

Cerebrospinal fluid (CSF) α-synuclein (α-syn) seed amplification assays (SAAs) can detect Lewy body pathology (LBP) with high accuracy but are invasive and costly. To address these challenges, this study evaluated a two-step workflow combining prescreening via smell-function testing with confirmatory CSF α-syn SAA testing only in individuals with reduced smell, for predicting postmortem LBP status

Digital innovation offers promising avenues for accessible, engaging, and user-friendly training solutions, crucial for promoting safety among manufacturing workers. However, optimizing these solutions demands a profound understanding of workers’ needs and preferences in interacting with these digital systems. The ongoing “DigiSafeMan” project aims to develop a prototype of a digital training tool

Background: Creatinine-based estimated glomerular filtration rate (eGFR) equations are widely used in clinical practice but exhibit inherent limitations. On the other side, measuring GFR is time consuming and not available in routine clinical practice. We developed and validated machine learning models to assess the trustworthiness (i.e. the ability of equations to estimate measured GFR (mGFR) wit

Background: The Danish Smoking Cessation Database (SCDB) was established in 2001 as the first national healthcare register within the field of health promotion.Aim of the database: The aim of the SCDB is to document and evaluate smoking cessation (SC) interventions to assess and improve their quality. The database was also designed to function as a basis for register-based research projects.Study

Natural hybridization occurs commonly in plants and blurs their interspecific delimitation. It is unclear whether spontaneous hybridization occurs in natural populations of Primula in China. In this study we examined natural hybridization between P. secundiflora and P. poissonii based on morphological and molecular analyses of individuals with intermediate morphology. Most morphological characters

Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucl

To clarify the origins of parent-child resemblance for drug abuse (DA), using national Swedish data, we fit path models to information on DA in parents and children from six informative family types: i) not-lived-with father, ii) not-lived-with mother, iii) stepfather, iv) stepmother, v) triparental, and vi) adoptive. From these families, we estimated parent-offspring resemblance reflecting the ef

Background: CSF concentration of neurogranin has been suggested as a biomarker for synapse dysfunction. Objectives: To investigate CSF neurogranin in parkinsonian disorders compared to controls and Alzheimer's disease and the possible correlations between neurogranin and cognitive and motor impairment. Methods: We included 157 patients with PD, 29 with PD with dementia, 11 with dementia with Lewy

We present a new methodology involving the simultaneous refinement of both x-ray absorption and x-ray diffraction spectra (x-ray absorption/diffraction structural refinement, XADSR) to study the hydration and ion pair structure of CaCl2 and RbBr salts in concentrated aqueous solutions. The XADSR method combines the x-ray absorption fine structure (XAFS) spectral analysis of both the cation and ani

BACKGROUND: Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds. OBJECTIVES: We analyzed associations between semen characteristics and serum xenoestrogen receptor (XER), xenoandrogen receptor (XAR), and aryl hydrocarbon receptor (AhR) transactivity. XER and XAR activity were measured in serum samples cleared for endogenous steroid hormones and AhR activity in r

The stereoselective reduction of ketones catalysed by alcohol dehydrogenase from Thermoanaerobium brockii was studied in different reaction media, hexane at controlled water activities, hexane with 2.5% water (biphasic) and pure water. The reactions were studied in the temperature range from -1 to 50°C. Increasing the water activity from 0.53 to 0.97 increased the reaction rate 16-fold. The rate w

Twelve commercially available triacylglycerol lipase preparations were screened for their suitability as catalysts in the interesterification of palm oil mid fraction and ethyl stearate to form a cocoa butter equivalent. Five fungal lipase preparations were found to be suitable. The hydrolytic activity of the commercial lipase preparations was tested with sunflower seed oil and was independent of

Biliary tract cancers (BTC) are rare and often diagnosed in late stages with advanced, nonresectable disease. The targeted agents panitumumab and bevacizumab have shown promising outcomes in combination with chemotherapy in other gastrointestinal (GI) cancers. We wanted to investigate if panitumumab or bevacizumab was the most promising drug to add to chemotherapy. Eighty-eight patients were rando

Assemblies of different molecules is a prevalent phenomenon in nature, and crucial in biological life. Most of the biological assemblies are co-assembledcomposites, made up from several different components, either of thesame biomolecular type or a combination of different ones. Knowledge regarding amyloid fibril structure and the mechanism behind it has been elucidated through the development of

Background Molecular DNA sequence data allow unprecedented advances in biodiversity assessments, monitoring schemes and taxonomic works, particularly in poorly-explored areas. They allow, for instance, the sorting of material rapidly into operational taxonomic units (such as BINs - Barcode Index Numbers), sequences can be subject to diverse analyses and, with linked metadata and physical vouchers,

Coarctation of the aorta is a congenital heart anomalyinvolving constriction of an aortic segment, associated with wall thickening of media and the formationof overlapping infolding of neointimal tissue. For thefirst time it was described by Morgagni in 1760. Thispathology represents 5% -7% of all congenital heartdiseases, with an incidence of approximately 3 casesto 10 000 neonates1. The typical