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Enhanced transglucosylation/hydrolysis ratio of mutants of Pyrococcus furiosus β-glucosidase : Effects of donor concentration, water content, and temperature on activity and selectivity in hexanol

The transglucosylation reaction catalyzed by wild-type β-glucosidase CelB from hyperthermophilic Pyrococcus furiosus and active site mutants (M424K, F426Y, M424K/F426Y) was studied. The conversion of pentyl-β-glucoside to hexyl-β-glucoside in hexanol was used as a model transglucosylation reaction. Hydrolysis to glucose was a side reaction. The activity (rates of hydrolysis and transglucosylation)

Long-lasting neuronal activity in rat dorsal horn evoked by impulses in cutaneous C fibres during noxious mechanical stimulation

The responses of 44 nociceptive neurones in the lumbar dorsal horn evoked by controlled mechanical stimulation of the skin, with or without conduction block in myelinated afferent fibres, were studied in the halothane-anaesthetized rat, in order to evaluate the effects of impulses in cutaneous nociceptive C fibres on dorsal horn neurones. Continuous non-noxious pinch of the skin evoked a short-lat

Plasma exchange or immunoadsorption in patients with rapidly progressive crescentic glomerulonephritis. A Swedish multi-center study

A therapeutic removal of antibodies may be achieved by immunoadsorption (IA) or by plasma exchange (PE). The aim of this prospective randomised study was to compare the efficacy of these different techniques with regard to treatment of patients with rapidly progressive glomerulonephritis (RPG) having at least 50% crescents. Forty-four patients with a RPG were included for treatment either by IA or

Impact on Health-Related quality of life after wearing compression garment or not for six months in women with mild breast cancer-related arm lymphedema. A cross-sectional study

Background: Women with mild breast cancer-related arm lymphedema (BCRAL) mostly receive treatment with compression garments and instructions in self-care to prevent the progression of lymphedema. However, wearing a compression garment may be experienced as negative and may affect health-related quality of life (HRQOL) more than the lymphedema itself. The aim of this study was to investigate if the

Broadband RF Front-End Featuring a Reconfigurable Q-Enhanced Filter for Upper Mid-Band 6G Receivers

This paper presents a radio frequency front-end (RFFE) comprised of a cascode low-noise amplifier (LNA) and a reconfigurable Q-enhanced filter. Employing a dual-resonant input matching network, the LNA attains a significantly wide bandwidth. The filter consists of four Q-enhanced resonators enabling three modes of operation: 1) dual-band filter, 2) single band-pass filter (BPF) along with a tunabl

Body size and substrate use affect ventral, but not dorsal, brightness evolution in lizards

Substrate properties can affect the thermal balance of organisms, and the colored integument, alongside other factors, may influence heat transfer via differential absorption and reflection. Dark coloration may lead to higher heat absorption and could be advantageous when substrates are cool (and vice versa for bright coloration), but these effects are rarely investigated. Here, we examined the ef

What drives Generation Z to choose green apparel? : unraveling the impact of environmental knowledge, altruism and perceived innovativeness

This study proposes to determine the influence of ‘Environmental Knowledge’ (EK), ‘Altruism’ (Atr), ‘Consumer Confidence’ (CC) and constructs of ‘Theory of Planned Behaviour’ (TPB) like Attitude” (Atd), ‘Subjective Norm’ (Sub) and ‘Perceived behavioural control’ (Pbhc) on consumers’ intention to purchase ‘Green Apparel Products’ (GAPI). Moreover, the moderating effect of ‘Perceived Innovativeness’

Musculoskeletal diseases, infections and vaccines : state of the art, research perspectives and educational needs

Musculoskeletal disorders are a significant public health burden concern, projected to increase in the coming decades, and will substantially contribute to the rising prevalence of functional impairment, frailty and disability in a growing global population. Since persons with musculoskeletal disorders tend to have immune dysfunction, inflammation or be taking immunosuppressive medication, prevent

Somatic and anxiety symptoms of depression are associated with disability in late life depression

Objectives: To assess the relationships of somatic and anxiety symptoms of depression with functional disability in a sample of older adults with late life depression. Method: Data were analyzed from 78 older adults aged 65–88 with current major depression. Somatic and anxiety symptoms from the 24-item Hamilton Depression Rating Scale (HDRS) were summed to create variables measuring severity of th

Synchrotron X-ray study of vacuum brazed 316L stainless steel joints

Nickel phosphide is a valuable material in high-temperature brazing and joining applications, offering excellent thermal stability for temperatures up to 400°C. Nickel phosphide is used as powder form for joining applications and therefore it is imperative to study the formation as well as interaction of Ni2P particles with Brazing with nickel-chromium-based fillers is widely used to join stainles

Global burned area increasingly explained by climate change

Fire behaviour is changing in many regions worldwide. However, nonlinear interactions between fire weather, fuel, land use, management and ignitions have impeded formal attribution of global burned area changes. Here, we demonstrate that climate change increasingly explains regional burned area patterns, using an ensemble of global fire models. The simulations show that climate change increased gl

Quantifying fossil fuel methane emissions using observations of atmospheric ethane and an uncertain emission ratio

We present a method for estimating fossil fuel methane emissions using observations of methane and ethane, accounting for uncertainty in their emission ratio. The ethane:methane emission ratio is incorporated as a spatially and temporally variable parameter in a Bayesian model, with its own prior distribution and uncertainty. We find that using an emission ratio distribution mitigates bias from us

Morganella morganii bloodstream infection affects the elderly in close contact with healthcare

BackgroundWe aimed to fill the gaps of knowledge concerning incidence rates and temporal trend, clinical features and risk factors for death for M. morganii bloodstream infections in south Sweden.MethodsThis was an observational, population-based study including all patients with at least one blood culture positive for Morganella morganii between 2013-2023 in Skåne, south Sweden.ResultsA total of

Biomarkers for iron metabolism among patients hospitalized with community-acquired pneumonia caused by infection with SARS-CoV-2, bacteria, and influenza

Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID-19. Few studies have investigated regulators of iron metabolism in the context of COVID-19. The aim was to evaluate biomarkers for iron metabolism in the acute phase response to community-acquired pneumonia (CAP) caused by SARS-CoV-2 compared with CAP caused by bacteria or influenza virus in hospital

One year weekly size-resolved air sampling of SARS-CoV-2 in hospital corridors and relations to the indoor environment

Background. Airborne SARS-CoV-2 plays a prominent role in COVID-19 transmission. Numerous studies have sampled air from patient rooms, but airborne spread to other hospital areas such as corridors is less investigated. Methods. Size-fractionated aerosol particles were collected weekly, with 12 hours of sampling time daily, in corridors at two infectious disease wards in southern Sweden between Mar

Reduction of fire spalling of concrete with small doses of polypropylene fibres

The addition of polypropylene (PP) fibres has been shown to reduce the fire spalling propensity of concrete. When including this type of fibres in the concrete, the concrete mix becomes less robust, and small deviations in the constitutes change the workability and properties of the concrete. So, from a manufacturing perspective as small dosages as possible of PP fibres are desirable. Very few lar

Changes in self-perceived performance and satisfaction with performance of daily activities following interdisciplinary rehabilitation in people with late effects of polio

Background: People with late effects of polio (LEoP) may need rehabilitation to manage everyday life but knowledge of the benefits of interdisciplinary rehabilitation is limited.Objective: To evaluate changes in performance and satisfaction with performance of activities among people with LEoP following interdisciplinary rehabilitation.Methods: A pre-post retrospective study based on data on 102 p