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Development of a successful prophylactic or therapeutic treatment for active Tuberculosis (TB) has been hampered by the bacilli’s ability to evade, tolerate, subvert host immunity and persist in a hypoxic intracellular niche. Upon infection with M. tuberculosis (Mtb), there is an increased demand for metabolites by cells to respond to the robust immune activation, which is met with a shift of meta
Artificial Intelligence has become a hot topic as improvements in available technologies previously considered science fiction, like image recognition, language processing, and self-driving vehicles, are becoming financially viable. Further, several studies point to how automation of processes will increase efficiency in a variety of white-collar sectors. The public sector is no exception, and the
The Lund Nuclear Microprobe (LNM) has been adapted to be used as a Single Ion Hit Facility (SIHF) for proton cell irradiation experiments at low dose. In order to test the capabilities of the system, Ni dot arrays and artificial cells have been fabricated with the photopolymer SU-8 and common lithographic techniques. The primary purpose of the Ni dot arrays was to determine the targeting accuracy
Background: Antithrombin concentrate (AT) is used to treat heparin resistance (HR) in cardiac surgery. It is usually given slowly due to the fear of anaphylaxis. This may delay cardiac catheterisation and the start of cardiopulmonary bypass (CPB). HR is often defined as the failure to reach or maintain a target activated clotting time (ACT) despite a standard dose of heparin. It is not generally p
Background: Gene expression has a strong stochastic element resulting in highly variable mRNA levels between individual cells, even in a seemingly homogeneous cell population. Access to fundamental information about cellular mechanisms, such as correlated gene expression, motivates measurements of multiple genes in individual cells. Quantitative reverse transcription PCR ( RT-qPCR) is the most acc
A novel algorithm for detection of saccades and postsaccadic oscillations in the presence of smooth pursuit movements is proposed. The method combines saccade detection in the acceleration domain with specialized on- and offset criteria for saccades and postsaccadic oscillations. The performance of the algorithm is evaluated by comparing the detection results to those of an existing velocity-based
The EU strategy for rural development 2014-2020 proposes a focus on tourism as a solution to bring economic, environmental and social aspects of sustainable development together. Using the case of fishing tourism in Sweden, we discuss the marketization of sustainable development on a destination market. We focus on the discursive and practical tension between ambitions for development and maintena
Secretagogin is a hexa EF-hand Ca(2+)-binding protein expressed in neuroendocrine, pancreatic endocrine and retinal cells. The protein has been noted for its expression in specific neuronal subtypes in the support of hierarchical organizing principles in the mammalian brain. Secretagogin has previously been found to interact with SNAP25 involved in Ca(2+)-induced exocytosis. Here, the cellular int
Enzymatic pretreatment of algae by means of cellulose degrading enzyme was evaluated through lab-scale and pilot-scale experiments. The degradation efficiency of the enzyme depended on the initial physical quality of the algae. Lab-scale batch anaerobic digestion experiments showed comparatively low methane potential for the pretreated algae at both mesophilic and thermophilic temperatures. Howeve
Based on the multi-configuration Dirac-Hartree-Fock method and using the GRASPVU package, a theoretical investigation was performed to study the lifetimes of hyperfine levels of the first excited level 3d(9)4s D-3(3) in Ni-like ions (Z = 72-79) for all stable isotopes with nuclear spin. Comparisons between hyperfine-induced electric quadrupole transition rates and the pure magnetic octupole transi
Treatment of sludge with enzymes has previously been shown to efficiently release organic matter. However, the added enzymes were partially adsorbed to, entrapped by or bound to the sludge structure. Simultaneous decrease of enzymes activities was observed. Reduced adsorption and more effective, lower, enzyme dose was achieved in sludge pre-treated with three cation-binding agents. The enzymatic s
The polarizability and other properties have been studied for F(-), Cl(-), Br(-), and HCOO(-) in water using a combined quantum chemical statistical mechanics simulation model that explicitly takes into account the Pauli repulsion as well as the electrostatic coupling between the QM system and the classical surroundings. It is shown that the surrounding molecules significantly reduce both the pola
This study examines motives for using financial bootstrapping in new businesses. First, it identifies and labels groups of new business founders based on their motives for using bootstrapping. Second, it examines the relation between variables referring to the founder and the business and the motives. The data were collected in a questionnaire sent by post to 120 new business founders in Swedish b
This thesis explores the concept of citizenship from the side of Roma women. Taking into consideration the peculiarity of the Greek case, in which Roma prefix their Greek identity, this case study is focused on the feeling of belonging in the Greek community that Roma women bear. Their citizenship is researched, building on the theory of anti-essentialism and is based on Dalton’s (2002) percep
This thesis investigates how the cinematographic techniques implemented during eating and sex scenes in movies involving queer characters affect the feelings of the spectator. In more detail, it proposes to elaborate on the emphasis placed on carnal pleasure and the corporeal sensation of queer characters with a specific focus on the corporeal reaction provoked in the viewer. The elaboration is bu
