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Background It is known that narrowband ultraviolet B (NB-UVB) radiation and oral vitamin D-3 supplementation can both improve serum levels of vitamin D, expressed as 25-hydroxyvitamin D-3 [25(OH)D-3]. However, surprisingly few studies have compared the effects of the two interventions in treating vitamin D deficiency. Objectives To compare the effect of NB-UVB exposure with oral vitamin D-3 supple

Common genetic variations in the gene encoding transcription factor 7-like 2 (TCF7L2) reveal the strongest association with type 2-diabetes known to date. These lead to impaired insulin production and output, but the mechanisms of disease remain incompletely known. In this issue of Diabetologia, two publications provide new insights into TCF7L2-dependent diabetes.

The combination of glucagon and glucagon-like peptide-1 (GLP-1) has been suggested as an approach to target obesity, since the two hormones have complementary action on body weight. We examined whether complementary action of the two hormones also exist on insulin secretion. Female C57BL/6 mice were injected intravenously with glucose with or without GLP-1, glucagon or the combination of GLP-1 and

Regular exercise has numerous health benefits, for example, it reduces the risk of cardiovascular disease and cancer. It has also been shown that the risk of type 2 diabetes can be halved in high-risk groups through nonpharmacological lifestyle interventions involving exercise and diet. Nevertheless, the number of people living a sedentary life is dramatically increasing worldwide. Researchers hav

Context: The incretin effect is the augmented insulin secretion by oral versus intravenous glucose at matching glucose levels. We previously demonstrated an augmented insulin secretion when fat is given orally rather than intravenously, suggesting an incretin effect also after fat. However, whether there is an incretin effect is also present after amino acid ingestion is not known. Objective: To e

Popular Abstract in Swedish Jet impingement och infraröd strålning är metoder för snabb värmeöverföring som kan användas för att snabba upp värmeprocesser i livsmedelsindustrin. Värmningshastigheten påverkar viktiga egenskaper hos livsmedlet, t.ex. brunfärgning. Jet impingement består av riktade strålar av luft med hög hastighet som träffar ytan på livsmedlet och minskar gränsskiktet mellan luftenRapid heat transfer methods such as jet impingement and infrared radiation can be used to speed up thermal processing in the food industry. The heating rate affects important food characteristics, such as colour. Jet impingement consists of directed jets of air with a high velocity that impinge on the food surface, which reduces the velocity boundary layer between the air and surface and gives a f

Being autonomous (or being an agent) does not describe an effective process and even if we succeeded in characterizing the conditions for being autonomous it would be of no use. Instead, it is the conditions of acting autonomously that should be of concern and the interest should be directed towards systems in which we can find, and possibly define, such acting processes. It turns out that anticip

Since the mid 90s more focus has been put on the problems surrounding hooliganism, especially in the media. This began when football referee Anders Frisk was injured during a football game. Nowadays, the police use more and more resources to prevent the problems with hooliganism and new laws have been instituted to handle the problem. More and more politicians, football players, coaches, and club

Titel: Marknadens leoparder - om first mover advantage och betydelsen av att vara först Seminariedatum: 30 maj 2012 Kurs: FEKN90, Examensarbete i företagsekonomi på magisternivå, 30 högskolepoäng. Författare: Victor Bengtsson & Mikael Falk Handledare: Matts Kärreman Fem nyckelord: First Mover Advantage, Red Queen, Konkurrensfördelar, Leoparder, Marknadsledare. Syfte: Syftet med studien Title: The Leopards of The Market - on First Mover Advantage and The Importance of Being First Seminar date: May 30th, 2012 Course: Master thesis in business administration, 30 University Credit Points (30 ECTS) Authors: Victor Bengtsson & Mikael Falk Advisor/s: Matts Kärreman Five key words: First Mover Advantage, Red Queen, Competitive Advantages, Leopards, Market Leadership. Purpose:

Retrieval Orientation refers to the differential processing of memory retrieval cues according to the sought after information (Rugg & Wilding, 2000). The study manipulated the orientation effect by varying the retrieval demand on a block basis using two emotional source recognition conditions and a non-emotional old-new recognition condition. Event-Related Potentials (ERPs) evoked by new face

Our ever-changing world has to a great extent created a need of efficient financial risk-management programs for financial institutions and corporations operating in a demanding international environment. These changes have however also increased the types of financial tools and derivatives used to handle the multifold macroeconomic exposures. Companies have therefore diversified opportunities to

Introduction: Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the

Background: Non-alcoholic fatty liver disease has been associated with increased mRNA expression of FADS2 in the liver and estimated activity of delta-6 desaturase in serum, encoded by the FADS2 gene. Since DNA methylation in the FADS1/2/3 gene cluster has been previously linked with genetic variants and desaturase activities, we now aimed to discover factors regulating DNA methylation of the CpG

Background: Sex differences are known to impact muscle phenotypes, metabolism, and disease risk. Skeletal muscle stem cells (satellite cells) are important for muscle repair and to maintain functional skeletal muscle. Here we studied, for the first time, effects of sex on DNA methylation and gene expression in primary human myoblasts (activated satellite cells) before and after differentiation int

Dysregulation of autophagy has been observed in obesity and type 2 diabetes. Salt-inducible kinase 2 (SIK2), a member of the AMPK-related kinase family, is downregulated in adipocytes from obese or insulin resistant individuals and was previously demonstrated to regulate autophagy in cancer and normal cell lines. The aim of this study was thus to investigate a potential role of SIK2 in the regulat

Chronic pain including temporomandibular disorder (TMD) pain involves a complex interplay between peripheral and central sensitization, endogenous modulatory pathways, cortical processing and integration and numerous psychological, behavioral and social factors. The aim of this study was to compare spectroscopic patterns of N-Acetyl-aspartate (NAA), total creatine (tCr), choline (Cho), myo-inosito

Offspring of women with gestational diabetes mellitus (GDM) are at increased risk of developing metabolic disease, potentially mediated by epigenetic mechanisms. We recruited 608 GDM and 626 control offspring from the Danish National Birth Cohort, aged between 9 and 16 years. DNA methylation profiles were measured in peripheral blood of 93 GDM offspring and 95 controls using the Illumina HumanMeth