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Genome editing of human pancreatic beta cell models : problems, possibilities and outlook

Understanding the molecular mechanisms behind beta cell dysfunction is essential for the development of effective and specific approaches for diabetes care and prevention. Physiological human beta cell models are needed for this work. We review the possibilities and limitations of currently available human beta cell models and how they can be dramatically enhanced using genome-editing technologies

Autoimmunogenetic Aspects of Vaccine-induced Narcolepsy. As part of the AMINA - Autoimmune Multiple Sclerosis and Narcolepsy Study.

Narcolepsy type 1 (NT1) is a neurological sleep disorder. The biological cause is the degeneration of hypocretin neurons located in the hypothalamus. It has been suggested that NT1 has an autoimmune pathogenesis, as in most patients, the Human Leukocyte Antigen (HLA)-DQB1*06:02:01 is present. An increased incidence of NT1 was observed in Sweden following the 2009 influenza Pandemrix®-vaccination.

Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study

OBJECTIVE The Environmental Determinants of Diabetes in the Young (TEDDY) study is uniquely capable of investigating age-specific differences associated with type 1 diabetes. Because age is a primary driver of heterogeneity in type 1 diabetes, we sought to characterize by age metabolic derangements prior to diagnosis and clinical features associated with diabetic ketoacidosis (DKA). RESEARCH DESIG

Transient increase in glucose variability during Ramadan fasting in patients with insulin-treated type 2 diabetes : A preliminary study

AIM: We aimed to examine the effect of Ramadan fasting on interstitial glucose control and variability before, during, and after Ramadan in type 2 diabetes patients receiving insulin therapy.METHODS: Participants received a flash glucose monitoring (FGM) system one week before Ramadan that was removed on the sixth or seventh day (pre- and early Ramadan periods) of Ramadan and a second FGM system o

Possible heterogeneity of initial pancreatic islet beta-cell autoimmunity heralding type 1 diabetes

The etiology of type 1 diabetes foreshadows the pancreatic islet beta-cell autoimmune pathogenesis that heralds the clinical onset of type 1 diabetes. Standardized and harmonized tests of autoantibodies against insulin (IAA), glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A) and ZnT8 transporter (ZnT8A) allowed children to be followed from birth until the appearance of a first islet auto

Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5-15-Year-Old Children Followed in the TEDDY Study

OBJECTIVE: This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5-15 years.RESEARCH DESIGN AND METHODS: As part of the longitudinal Environmental Determinants of Diabetes in the Young (TEDDY) study, annual assessment of activity using accelerometry was conducted from age 5 years. Time-to-ev

Nyfikna besökare på Kulturnatten

Nyfikna besökare på Kulturnatten Nyfikna besökare på Kulturnatten Publicerad den 23 september 2019 Ulla Sjöberg och Erik Mossfeldt spelar in sina röster under Kulturnatten. Ioanna Dimitrakopoulou hjälper dem att analysera inspelningen. Historiska sånger, latin, danska och fonetik lockade besökare till Språk- och litteraturcentrum under årets Kulturnatt. Startskottet för kvällen var Lunds Renässans

https://www.sol.lu.se/article/nyfikna-besoekare-paa-kulturnatten/ - 2026-06-04

Civilingenjörsutbildning i teknisk nanovetenskap utbildningsplan

Civilingenjörsutbildning i teknisk nanovetenskap utbildningsplan Sida 1 av 7 UTBILDNINGSPLAN Civilingenjörsutbildning i teknisk nanovetenskap - Programkod: TATNA - Omfattning: 300 högskolepoäng - Tillträdesnivå: Grundnivå - Beslutsfattare: Programledning N - Utbildningsplanens giltighet: 2022/2023 - Utbildningsplanen fastställd: 2022-02-21 Förutom utbildningsplanen för denna utbildning gäller även

https://www.student.lth.se/fileadmin/student/files/utbildningplaner_22_23_civiling_hogskoleing_kand_basaar/Civilingenjoersutbildning_i_teknisk_nanovetenskap_22-23.pdf - 2026-06-04

Early life intake of marine n-3 fatty acids, genetic fatty acid desaturase variants, and risk of celiac disease.

Background: We aimed to investigate if early life marine n-3 fatty acids and fish intake, and fatty acid desaturase (FADS) genetic variants, were associated with later risk of celiac disease (CeD).Methods: Among 85,244 children in the prospective Norwegian Mother, Father, and Child Cohort Study, fish and marine fatty acid intakes were estimated from questionnaires to mothers during pregnancy, and

Efficacy of once-daily, high-dose, oral insulin immunotherapy in children genetically at risk for type 1 diabetes (POInT): a European, randomised, placebo-controlled, primary prevention trial

Background Type 1 diabetes begins with autoimmunity against pancreatic islet antigens, including insulin. The aim of the Primary Oral Insulin Trial (POInT) was to evaluate the efficacy and safety of daily high-dose oral insulin to prevent the development of islet autoantibodies and diabetes. Methods In this randomised, controlled, primary prevention trial, genetic screening in seven obstetric and

Adiposity-based obesity classification and cardiometabolic and kidney outcomes: a longitudinal UK Biobank analysis

BackgroundObesity is commonly diagnosed using BMI, which does not capture total adiposity or fat distribution, as highlighted by the recent Lancet D&E Commission report. We assessed the prognostic value of an adiposity-based classification combining body fat percentage (BF%) and waist circumference (WC) in relation to cardiometabolic and kidney outcomes and evaluated its concordance with BMI.M

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Title Master’s Dissertation Structural Mechanics Report TV SM -5245 C H RISTO PH ER H A ST and D A N IEL FA TEM I B EH A V IO U R O F C R O SS LA M IN A TED TIM B ER ELEM EN TS W ITH O PEN IN G S A T O U T-O F-PLA N E LO A D IN G C O N D ITIO N S CHRISTOPHER HAST and DANIEL FATEMI BEHAVIOUR OF CROSS LAMINATED TIMBER ELEMENTS WITH OPENINGS AT OUT-OF-PLANE LOADING CONDITIONS DEPARTMENT OF CONSTRUCTI

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5245.pdf - 2026-06-04

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Quantifier Scope Interaction in Korean and English Introduction. The contrast in scope ambiguity between English and Korean in (1-2) has been a topic of research. Huang (1982: 220) and Hoji (1985: 248) argue that quantifier scope in languages like Korean, Chinese and Japanese is determined by the surface word order contra English. Recently, some researchers (Hornstein 1995 among others) proposed t

https://konferens.ht.lu.se/fileadmin/user_upload/sol/ovrigt/konferens_console9_2000/Abstracts/Choi.pdf - 2026-06-04

Brevmall

Brevmall 1 LTH:s kans l i CEQ-pro jektgruppen Jonas Bore l l Lathund för tolkning a CEQ-arbetsrapporter Inledning CEQ på LTH CEQ1 är en komponent i utvärderingsarbetet, so LTH2. God kvalitet hos grundutbildning innebär LTH finns en idé om att pedagogisk utveckling s undervisningen. Denna idé utgör grunden för Ge utbildningen på LTH. CEQ-enkäterna är tänkta samtal. CEQ ger data och uppslag till ref

https://www.ceq.lth.se/info/dokument/filer/lathund_CEQ.pdf - 2026-06-04

Ll ksmc62 rev171123

LL_KSMC62_rev171123 Litteraturlista för Affärsutveckling i upplevelseekonomin, (KSMC62) 15 hp Litteraturlistan är fastställd av styrelsen för institutionen för service management och tjänstevetenskap 2016-11-16, senast reviderad 2017-11-23. Litteraturlistan börjar gälla 2018-01-01. Belk, Russell (2014). You are what you can access: Sharing and collaborative consumption online. Journal of Business

https://www.ses.lu.se/sites/ses.lu.se/files/ll_ksmc62_rev171123.pdf - 2026-06-04

Info stu 20min

Studieverkstaden Individuell handledning, kurser, föreläsningar Via mejl: studieverkstad@stu.lu.se Via telefon: 046-222 43 92 Läs mer på vår hemsida: www.lu.se/studieverkstad Studieverkstaden Boka en tid! Presentatör Presentationsanteckningar Om du någon gång under kursen skulle vilja prata med någon om akademiskt skrivande, studieteknik eller muntliga presentationer – boka en tid hos Studieverkst

https://www.psy.lu.se/sites/psy.lu.se/files/info_stu_20min.pdf - 2026-06-04

Corvellec hultman nsr 21 nov 2012

Handledningsaritmetik Konsten att skapa olika slags värde ur avfall Hervé Corvellec & Johan Hultman Institution för Service Management, Campus Helsingborg, Lunds Universitet FoU dag på NSR 21 november 2012 Olika syn på värde Tre traditionella syn om värde inom ekonomiläran Arbetsvärde (Labour value) Utbytesvärde (Exchange value) Bruksvärde (Value in use) Uppmärksammad inom service management Behov

https://www.ses.lu.se/sites/ses.lu.se/files/corvellec_hultman_nsr_21_nov_2012.ppt - 2026-06-04

Civilingenjörsutbildning i medicin och teknik utbildningsplan

Civilingenjörsutbildning i medicin och teknik utbildningsplan Sida 1 av 7 Utbildningsplan Civilingenjörsutbildning i medicin och teknik - Programkod: TAMTE - Omfattning: 300 högskolepoäng - Tillträdesnivå: Grundnivå - Beslutsfattare: Programledning BME - Utbildningsplanens giltighet: 2024/2025 - Utbildningsplanen fastställd: 2024-02-15 1 Syfte och mål 1.1 Syfte Medicin och teknik är ett tvärvetens

https://www.student.lth.se/fileadmin/lth/student/Utbildningsplaner_2023_och_fram/Grund_svenska/24_25/Utbildningsplan_Civilingenjoersutbildning_i_medicin_och_teknik_24-25.pdf - 2026-06-04