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Chaperones may retard the aggregation of other proteins and increase their solubility. An important goal is a thermodynamic understanding of such an action. Here, the chaperone DNAJB6b (JB6) is found to suppress amyloid formation of the protein α-synuclein (α-syn) leading to a reduced rate of fibril formation and an increase in apparent solubility of α-syn. These findings were reached at mildly ac
A standard analysis of moral responsibility states that an agent A is morally responsible for φ-ing if and only if it is fitting to have—depending on the nature of φ—a negative or positive reactive emotion vis-à-vis A on account of A's φ-ing. Proponents of Alethic views of moral responsibility maintain that the relevant notion of fittingness in the analysis should be understood in terms of accurat
It is investigated how particles in high-N shells affect the moment of inertia, {A figure is presented}(2), and the quadrupole moment, Q0, of superdeformed high-spin states. The different behaviour of {A figure is presented}(2) versus the rotational frequency observed for superdeformed states in 152Dy and 149Gd is explained in terms of different occupations of a few high-N orbits. Predictions for
Abstract: The Abrasion–Ablation Monte Carlo for Colliders (AAMCC) model is used to study the characteristics of spectator matter in central collisions of relativistic 238U nuclei, which are sensitive to the mutual orientation and the degree of deformation of the colliding nuclei. It is shown that the multiplicity of spectator neutrons and their forward-backward asymmetry substantially depend on th
AI systems are increasingly being used to shift decisions made by humans over to automated systems, potentially limiting the space for democratic participation. The risk that AI erodes democracy is exacerbated where most people are excluded from the ownership and production of AI technologies that will impact them.AI learns through datasets but, very often, that data excludes key parts of the popu
There are seventeen million people in the world who are stateless, not considered as citizens by any state. They suffer due to the current function of citizenship in the nation-state system, occupying a legal space outside of the system, yet, their lives are very much blighted by the system itself. This research examines the possibility that global citizenship could be a means to address stateless
Companies — for profit commercial corporations — shape our world, and our world is shaped to the service of companies. The superhuman capabilities of companies and the enormous resources at their disposal has allowed them to massively transform our natural and social environment. Some argue that we are not living in the Anthropocene, but rather in the Technocene—a geological era brought about not
What does it mean to pose the solidarity question today? Beyond all analyses, solidarity remains first and foremost an event. In this book, leading authorities in law, philosophy and political sciences respond to the solidarity question, drawing on debates on international law, international aid, collective security, joint action, market organization and neoliberalism, international human rights
Ancient genomes provide a tool to investigate the genetic basis of adaptations in extinct organisms. However, the identification of species-specific fixed genetic variants requires the analysis of genomes from multiple individuals. Moreover, the long-term scale of adaptive evolution coupled with the short-term nature of traditional time series data has made it difficult to assess when different ad
This chapter argues that the international community’s response to the Syrian civil war was a failure of resolute diplomacy. It first recounts how a popular uprising was brutally suppressed by the Bashar al-Assad government’s military forces, sparking a ‘new war’ where many of the protagonists have more to gain from war than peace. It then considers the diplomatic strategies pursued by regional an
We present an analytical method for the in situ measurement of atmospheric nitrogen trifluoride (NF 3), an anthropogenic gas with a 100-year global warming potential of over 16 000. This potent greenhouse gas has a rising atmospheric abundance due to its emission from a growing number of manufacturing processes and an expanding end-use market. Here we present a modified version of the "Medusa" pre
East Coast Fever is a devastating African cattle disease caused by the apicomplexan parasite, Theileria parva. Little is known about the cell surface, and few proteins have been identified. Here, we take an in silico approach to identify novel cell surface proteins, and predict the structure of four key proteins.
Understanding the nature of the photoexcitation and ultrafast charge dynamics pathways in organic halide perovskite nanocubes and their aggregation into superlattices is key for potential applications as tunable light emitters, photon-harvesting materials, and light-amplification systems. In this work, we apply two-dimensional coherent electronic spectroscopy (2DES) to track in real time the forma
Background: The incidence of celiac disease (CD) has increased rapidly in the late 20th and early 21st centuries, but there are recent reports of rates levelling off in countries with a high prevalence. The aim of this study was to investigate current trends in CD in southern Sweden. Patients and methods: Children and adults diagnosed with CD by biopsy or serology in the region of Skåne, southern
We present calculations on the formation of 258Rf in the reaction 50Ti+208Pb within the Langevin framework. The initital stage after contact of the colliding nuclei is dominated by a drift in the center-of-mass direction, while the subsequent process of forming a compound nucleus is diffusion dominated. The probability for the composite system to diffuse over the inner saddle is obtained by perfor
