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In an attempt to shed light on the role of the polyamines, putrescine, spermidine, and spermine in cell cycle progression, polyamine biosynthesis has been analyzed during the cell cycle of Chinese hamster ovary cells, and cell cycle kinetics have been investigated in cells treated with polyamine biosynthesis inhibitors. Cells were synchronized with the mitotic detachment technique, and at various

This paper describes the implementation and evaluation of a generic component to extract temporal information from texts in Swedish. It proceeds in two steps. The first step extracts time expressions and events, and generates a feature vector for each element it identifies. Using the vectors, the second step determines the temporal relations, possibly none, between the extracted events and orders

Executive summary The general aim of this report is to establish the state of the art of Impact Assessment (IA) in the EC and some selected European countries, while comparing the formal political advances with impact assessment work in practice. Two of the selected countries belong to the group that is identified as forerunners in IA development, Sweden and UK. France is an example of a country w

Oncogene-induced senescence (OIS) is a persistent anti-proliferative response that acts as a barrier against malignant transformation. During OIS, cells undergo dynamic remodeling, which involves alterations in protein and organelle homeostasis through autophagy. Here, we show that ribosomes are selectively targeted for degradation by autophagy during OIS. By characterizing senescence-dependent al

Friction characteristics and wear of sheet-bulk metal forming tools featuring microstructured surfaces are simulated on the mesoscale. Computational homogenisation is used for surface cut-outs on which the structures are geometrically resolved and where friction laws model lower scale roughness. Two approaches are presented for the modelling of wear. A dissipation based Archard model is implemente

The technical development of high-throughput sequencing technologies and the parallel development of targeted therapies in the last decade have enabled a transition from traditional medicine to personalized treatment and care. In this way, by using comprehensive genomic testing, more effective treatments with fewer side effects are provided to each patient—that is, precision or personalized medici

Archamoebae comprises free-living or endobiotic amoebiform protists that inhabit anaerobic or microaerophilic environments and possess mitochondrion-related organelles (MROs) adapted to function anaerobically. We compared in silico reconstructed MRO proteomes of eight species (six genera) and found that the common ancestor of Archamoebae possessed very few typical components of the protein trans