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Acute lymphoblastic leukemia (ALL) is a highly aggressive pediatric cancer that can affect both B cells and T cells. The advent of new therapies has increased the cure rates for both B-ALL and T-ALL patients. However, some patients still experience relapse with a variable response to the treatment and display poor survival. Thus,identification of novel predictive biomarkers that can predict therap

The molecular mechanism behind affinity maturation is the introduction of point mutations in immunoglobulin (Ig) V genes, followed by the selective proliferation of B cells expressing mutants with increased affinity for antigen. An in vitro culture system was developed in which somatic hypermutation of Ig V genes was sustained in primed B cells. Cognate T cell help and cross-linking of the surface

Hypertension is the leading risk factor for premature death worldwide. The identification of modifiable causes of hypertension remains an imperative task. We aimed to investigate associations between 79 proteins implicated in cardiovascular disease and longitudinal blood pressure (BP) changes in three Swedish prospective cohorts. In a discovery phase, we investigated associations between baseline

Syftet med forskningen som presenteras i denna avhandling är att vidareutveckla tillgänglighetsområdet i riktning mot en större perspektivrikedom. Avhandlingen baseras på kulturhistorisk aktivitetsteori (CHAT). Den analyserar en systemisk helhet utifrån sådana mänskliga, artefaktuella och naturliga faktorer som påverkar en individs handlingsmöjligheter i konkreta situationer.Avhandlingen har två h

An electronic device requires valid control keys to change any usage restriction setting. The device is provided control keys, a secret key, and a signed software object including a batch ID and a hash of the secret key. For each control key, the device generates a cryptographic footprint bound to the device and the secret key. A message authentication code (MAC) of each usage restriction setting

This paper analyzes the adoption of Additive Manufacturing (AM) technologies in Sweden. The dataset consists of a recent and representative sample of Swedish AM users (companies, universities, and research institutes). The authors investigate two questions. Firstly, what are the current applications of AM in Sweden (e.g. Rapid Prototyping (RP), production)? Secondly, what are the factors that can

It is well established that the nutrient and energy requirements of birds increase substantially during moult, but it is not known if these increased demands affect their aerobic capacity. We quantified the absolute aerobic scope of house and Spanish sparrows, Passer domesticus and P. hispaniolensis, respectively, before and during sequential stages of their moult period. The absolute aerobic scop

Literature compilation.Part of the project: “Histories of Philosophy in Global Perspective”. Under the heading "Histories of Philosophy", you will find a compliation of all works on the history of philosophy known to us, sorted by the language of publication. You will also find a list of all works on the global history of philosophy and a collection of works on the theory of the historiography of philosophy. All these d

In this paper, we are concerned with the ethical implications of the distinction between natural reproduction (via sexual intercourse) and reproduction that requires assistance (either medical or social). We argue that the current practice of enforcing regulations on the latter but not on the former means of reproduction is ethically unjustified. It is not defensible to tolerate parental ignorance

Hepatitis B virus (HBV) infection remains a major public health threat in the Middle East and North Africa (MENA). Phylogenetic analysis of HBV can be helpful to study the putative transmission links and patterns of inter-country spread of the virus. The objectives of the current study were to analyze the HBV genotype/sub-genotype (SGT) distribution, reverse transcriptase (RT), and surface (S) gen

Mixtures of epoxy resins in the presence of epoxy hyperbranched polymers (HBP), in the range of 5-15 wt%, were investigated in the cationic photocuring process. No significant differences in rate of polymerization or final epoxy groups conversion were observed. At low concentration, HBP acts as plasticizer and causes a decrease of the glass transition temperature of the epoxy matrix and of the E'

This paper extends the application of Bayesian inference to probability distributions defined in terms of its quantile function. We describe the method of *indirect likelihood* to be used in the Bayesian models with sampling distributions which lack an explicit cumulative distribution function. We provide examples and demonstrate the equivalence of the "quantile-based" (indirect) likelihood to the

The effect of clock skew and duty-cycle on the performance of high-Q N-phase band-pass filters (BPFs) have been examined in this paper. Following a mathematical approach and using the analytical derivations carried out, the effects of such non-idealities as clock skew and duty-cycle error are determined in an N-path filter. It is analytically proved that image signals from all integer multiples of

With the Neolithic transition, human lifestyle shifted from hunting and gathering to farming. This change altered subsistence patterns, cultural expression, and population structures as shown by the archaeological/zooarchaeological record, as well as by stable isotope and ancient DNA data. Here, we used metagenomic data to analyse if the transitions also impacted the microbiome composition in 25 M

All children less than 18 years of age who were diagnosed with a first episode of kidney stones at pediatric referral centers in Iceland during the years 1995-2000 were studied retrospectively. The diagnosis was based on clinical features and results of imaging studies. Patients were invited for evaluation at the end of the study period. Twenty-six patients (15 females, 11 males), median age 9.4 (