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Differential expression of microRNAs (miRNAs) is observed in many diseases including type 2 diabetes (T2D). Insulin secretion from pancreatic beta cells is central for the regulation of blood glucose levels and failure to release enough insulin results in hyperglycemia and T2D. The importance in T2D pathogenesis of single miRNAs in beta cells has been described; however, to get the full picture, h

During a voluntary contraction, motor units (MUs) fire a train of action potentials, causing summation of the twitch forces, resulting in fused or unfused tetanus. Twitches have been important in studying whole-muscle contractile properties and differentiation between MU types. However, there are still knowledge gaps concerning the voluntary force generation mechanisms. Current methods rely on the

Sense of Coherence (SOC), comprising comprehensibility, manageability and meaningful-ness, is important for the sense of living a good life with Late Effects of Polio (LEoP). However, there is a lack of knowledge about the meaning of these three components. The aim of this study was to explore in-depth the meaning of SOC among persons living with LEoP, in terms of comprehensibility, manageability

The purpose of this study was to examine the relation between technostress, performance based self-esteem (PBS) and burnout among employees, further if technostress beyond PBS could act as a predictor for burnout. The participants in the study were white collar workers from a Swedish manufacturing industry who on a daily basis were using computer and information technology in their work. These com

Seeking to identify alternative intervention techniques, to reduce mortality in war becomes more extensive. Some methods are met with more criticism than others. Psychological operations are not a new phenomenon, but starts to be used more and more, and is also a new addition for the Swedish Armed Forces. This paper therefore intends to explore how the moral justification for these operations migh

In an attempt to bring about the end to a conflict situation at all costs, peace agreements often end up containing terms that may be deemed controversial. One such example would be terms that confer immunity on perpetrators of international crimes. Concurrently, there exist in international law legal norms that require, or allow, States to pursue a criminal prosecution regarding perpetrators of s

Abstract Over the past decade, mass spectrometry has had an essential role in improvement of proteomics techniques. New instrument and analytical protocol developments have made mass spectrometry one of the most widely used analytical methods in quantitative proteomics. Today one of the commonly used protocols in proteomics is digestion of proteins to peptides and analysis of the peptides with li

Sammanfattning Denna uppsats har till syfte att redogöra för gällande rätt kring expropriation i Sverige samt hur ingreppet påverkas av egendomsskyddet i RF. Vidare behandlas i korthet hur rättsområdet har utvecklats under 1900-talet samt hur EKMR har influerat den svenska rätten. Uppsatsen innehåller ett komparativt avsnitt där den danska expropriationsrätten samt det konstitutionella egendomssky

Psychiatric and metabolic features appear several years before motor disturbances in the neurodegenerative Huntington's disease (HD), caused by an expanded CAG repeat in the huntingtin (HTT) gene. Although the mechanisms leading to these aspects are unknown, dysfunction in the hypothalamus, a brain region controlling emotion and metabolism, has been suggested. A direct link between the expression

In this essay we discuss the importance of the rule of law for upholding fundamental rights within the liberal democratic state formation. The case in point is that of the Jamaica state and its longstanding record of arbitrary human rights practices. Under the rule of law all parts of the state apparatus is subject to the principals of legality and accountability, this entails testing the legality