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It is possible to disagree on nearly everything when it comes to human agency. Nonetheless, certain things are written in stone. One thinks. One acts. One makes mistakes. My focus in this dissertation is on these three simple facts and the relation between them. I am fascinated by the different roles that knowledge plays with each: that is, the kind of knowledge one has of thoughts, actions, and m

The purpose of my article is to highlight the development and activities of the Catholic traditionalist minority groups and discuss their importance in today’s Catholic Church. The traditionalist movement started as a reaction to the reforms implemented as a result of the Second Vatican Council (1962-1965), which for many conservative-minded Catholics appeared as a departure from Catholic faith an

During a voluntary contraction, motor units (MUs) fire a train of action potentials, causing summation of the twitch forces, resulting in fused or unfused tetanus. Twitches have been important in studying whole-muscle contractile properties and differentiation between MU types. However, there are still knowledge gaps concerning the voluntary force generation mechanisms. Current methods rely on the

It has long been known that the three largest subunits in the membrane domain (NuoL, NuoM and NuoN) of complex I are homologous to each other, as well as to two subunits (MrpA and MrpD) from a Na+ /H+ antiporter, Mrp. MrpA and NuoL are more similar to each other and the same is true for MrpD and NuoN. This suggests a functional differentiation which was proven experimentally in a deletion strain m

Clin Microbiol InfectAbstract The usefulness of spa typing was evaluated in relation to pulsed-field gel electrophoresis (PFGE), as a tool for epidemiological typing of methicillin-resistant Staphylococcus aureus (MRSA) in a low-prevalence region in southern Sweden. Bacterial isolates from 216 MRSA cases, newly identified in 2000-2004, were studied. The isolates were obtained from infected patient

Phosphodiesterase type 3B (PDE3B) has been shown to be activated and phosphorylated in response to insulin and hormones that increase cAMP. In order to study serine/threonine protein phosphatases involved in the regulation of rat adipocyte PDE3B, we investigated the phosphorylation and activation of PDE3B in vivo in response to phosphatase inhibitors and the dephosphorylation and deactivation of P

Telavancin is a novel bactericidal lipoglycopeptide with multiple mechanisms of action against gram-positive pathogens. The aim of this study was to describe the dynamics of the antimicrobial effect of telavancin against two strains of Staphylococcus aureus (methicillin susceptible and methicillin resistant) in an in vitro kinetic model with simulated human pharmacokinetics. Also, static experimen

The N-terminal RNA binding domain of U1A has been shown to fold in a two-state process without accumulating any intermediates. U1A has a symmetrically curved chevron plot which seems to result mainly from changes of the transition state. At low concentrations of denaturant the transition state occurs early in the folding reaction, whereas at high denaturant concentration it moves close to the nati

Carbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. Galectins are a family of carbohydrate binding proteins thatbind to polysaccharides containing a galactose. Galectins have the ab

There is a scarcity of instruments for assessing opportunities for residentswith psychiatric disabilities to engage in meaningful home-based activities.We thus developed the Perceived Meaning of Activity in Housing (PMA-H),containing four subscales (activity opportunities, social interaction, developingas a person, and organization and planning). The aim of the study was to investigate the content

Elevated formation of bradykinin (BK) and Lys-BK or kallidin (KD) and their carboxypeptidase metabolites desArg9BK and desArg10KD is evident at sites of inflammation. Moreover, B2 receptors (B2R) which mediate the action of BK and KD, participates in the acute stage of the inflammatory and pain response, whereas B1 receptors (B1R), through which desArg9BK and desArg10KD act, partake in the chronic

BACKGROUND: The association between knee alignment and knee pain in knee osteoarthritis (OA) is unclear. High tibial osteotomy, a treatment option in knee OA, alters load from the affected to the unaffected compartment of the knee by correcting malalignment. This surgical procedure thus offers the possibility to study the cross-sectional and longitudinal association of alignment to pain. The aims

A constitutive model for aluminum alloys under hot working conditions is proposed. The elastic-viscoplastic model is implemented in a finite strain continuum mechanical framework. The model accounts for the interplay between dynamic recovery and recrystallization during hot working of aluminum alloys and central aspects of microstructure evolution such as grain/subgrain size and dislocation densit

A test of CP invariance in Higgs boson production via vector-boson fusion is performed in the H→ττ decay channel. This test uses the Optimal Observable method and is carried out using 36.1fb−1 of s=13TeV proton–proton collision data collected by the ATLAS experiment at the LHC. Contributions from CP-violating interactions between the Higgs boson and electroweak gauge bosons are described by an eff

The contemporary book business is both globalized and digitalized, whether we are talking international bestsellers or micropublished digital-only e-books. All categories of literature have been profoundly marked by technological and social change. Despite being polar opposites, large-scale media conglomerate publishing and micropublishing are discussed jointly in the article. Globalization and di

Pilot-scale tests were run with ozonation for reduction of 24 pharmaceuticals at 10 full-scale wastewater treatment plants in southern Sweden. Reduction was evaluated based on doses of 3, 5 and 7 g O3/m3 at all plants. The reduction of pharmaceuticals reached on average 65% at 3 g O3/m3, 78% at 5 g O3/m3 and 88% for 7 g O3/m3 in terms of total concentration of pharmaceuticals. Specific ozone dose